CAS: Catalytic sp3 Carbon-Hydrogen (C-H) Functionalization with Earth Abundant Metals
CAS:利用地球丰富的金属进行催化 sp3 碳-氢 (C-H) 官能化
基本信息
- 批准号:1955942
- 负责人:
- 金额:$ 49.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With this award, the Chemical Catalysis Program of the NSF Division of Chemistry is supporting the research of Professor Timothy Warren of the Department of Chemistry at Georgetown University to develop sustainable catalysts that link abundant chemical building blocks. Using catalysts to link molecular fragments by the formation of new carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds usually requires multi-step chemical processes to first activate the molecular fragments so that they are more reactive. Professor Warren and his team of graduate and undergraduate researchers are designing new ways to connect chemical building blocks using carbon-hydrogen bonds that are difficult to break but found in most feedstock chemicals. The catalysts that are being developed for these reactions are derived from earth abundant copper. These studies involve experiments designed to gain fundamental insight into how the catalysts work to be able to improve their performance in the advanced manufacture of industrial chemicals. This project is providing training for a diverse group of students. Dr. Warren and his group introduce the general public to chemistry at the biannual USA Science and Engineering Festival in Washington, DC. The team will continue to work with young scientists at the beginning of their scientific careers. Each summer a high school student will gain valuable experience and access to a range of more experienced scientists (undergrads, grads, PI) while contributing to the chemical enterprise. Finally, Professor Warren and his students will also provide day-long, hands-on laboratory experiences each summer for rising high school seniors from the Cristo Rey and KIPP networks that serve underprivileged, low-income, and diverse student populations that illustrate connections between Chemistry and the Environment.Catalytic reactions for the conversion of carbon-hydrogen (C-H) bonds in abundant chemical feedstocks to value-added carbon-nitrogen (C-N), carbon-oxygen (C-O), and carbon-carbon (C-C) bonds are valuable for improving the efficiency of synthetic processes. These transformations bypass the steps required to activate reagents and simultaneously decrease waste. Professor Warren and his research group have discovered that a copper-catalyzed radical relay reaction can be used to functionalize C-H bonds and they are currently investigating new synthetic transformations that can be achieved with this catalytic system. These studies involve optimizing the catalyst to accommodate new types of reagents to react with the C-H bonds, exploring new oxidants to decrease the excess amount of alkane currently required, and investigating asymmetric systems for C-H amidation. In addition, fundamental mechanistic studies are being performed to collect information that will facilitate further development and optimization. These research activities also serve as a training ground for a diverse group of graduate, undergraduate, and high school students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
美国国家科学基金会化学部化学催化项目通过该奖项支持乔治城大学化学系蒂莫西·沃伦教授的研究,以开发可持续的催化剂,将丰富的化学组成部分连接起来。使用催化剂通过形成新的碳-碳、碳-氮和碳-氧键来连接分子片段,通常需要多步化学过程,首先激活分子片段,使其更具活性。沃伦教授和他的研究生和本科生研究团队正在设计利用碳氢键连接化学构件的新方法,这种键很难断裂,但在大多数原料化学品中都有发现。正在开发的用于这些反应的催化剂是从富含地球资源的铜中提取的。这些研究涉及的实验旨在获得催化剂如何工作的基本见解,从而能够提高它们在工业化学品先进制造中的性能。这个项目为不同的学生群体提供培训。沃伦博士和他的团队在华盛顿特区举行的两年一度的美国科学与工程节上向公众介绍化学。该团队将继续与刚开始科学生涯的年轻科学家一起工作。每年夏天,一名高中生将获得宝贵的经验,并接触到一系列更有经验的科学家(本科生,研究生,PI),同时为化工企业做出贡献。最后,沃伦教授和他的学生每年夏天还将为来自Cristo Rey和KIPP网络的高中毕业生提供为期一天的动手实验室体验,这些网络服务于贫困,低收入和多样化的学生群体,说明化学与环境之间的联系。丰富的化学原料中的碳氢键(C-H)转化为增值的碳氮键(C-N)、碳氧键(C-O)和碳碳键(C-C)的催化反应对提高合成过程的效率有价值。这些转化绕过了激活试剂所需的步骤,同时减少了浪费。Warren教授和他的研究小组发现,铜催化的自由基接力反应可以用来功能化C-H键,他们目前正在研究新的合成转化,可以用这种催化系统来实现。这些研究包括优化催化剂以适应与C-H键反应的新型试剂,探索新的氧化剂以减少目前所需的过量烷烃,以及研究C-H酰胺化的不对称系统。此外,正在进行基本的机械研究,以收集有助于进一步发展和优化的信息。这些研究活动也为研究生、本科生和高中生提供了一个训练基地。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Copper-Catalyzed C(sp3)–H Methylation via Radical Relay
通过自由基中继的铜催化 C(sp3)→H 甲基化
- DOI:10.1021/acscatal.2c02474
- 发表时间:2022
- 期刊:
- 影响因子:12.9
- 作者:Figula, Bryan C.;Chen, Ting-An;Bertke, Jeffery A.;Warren, Timothy H.
- 通讯作者:Warren, Timothy H.
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Timothy Warren其他文献
Timothy Warren的其他文献
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{{ truncateString('Timothy Warren', 18)}}的其他基金
CAS: Catalytic sp3 Carbon-Hydrogen (C-H) Functionalization with Earth Abundant Metals
CAS:利用地球丰富的金属进行催化 sp3 碳-氢 (C-H) 官能化
- 批准号:
2303206 - 财政年份:2022
- 资助金额:
$ 49.03万 - 项目类别:
Standard Grant
SusChEM: C-H Functionalization with Earth Abundant Metals
SusChEM:利用地球丰富的金属进行 C-H 官能化
- 批准号:
1665348 - 财政年份:2017
- 资助金额:
$ 49.03万 - 项目类别:
Continuing Grant
Modeling Nitric Oxide Signaling Chemistry at Non-Heme Sites
模拟非血红素位点的一氧化氮信号化学
- 批准号:
1459090 - 财政年份:2014
- 资助金额:
$ 49.03万 - 项目类别:
Continuing Grant
Modeling Nitric Oxide Signaling Chemistry at Non-Heme Sites
模拟非血红素位点的一氧化氮信号化学
- 批准号:
1413281 - 财政年份:2014
- 资助金额:
$ 49.03万 - 项目类别:
Continuing Grant
SusChEM: Copper Catalyzed C-H Functionalization
SusChEM:铜催化的 C-H 官能化
- 批准号:
1300774 - 财政年份:2013
- 资助金额:
$ 49.03万 - 项目类别:
Standard Grant
HNO, NO, and RSNO Formation and Reactivity at Non-Heme Sites
HNO、NO 和 RSNO 在非血红素位点的形成和反应性
- 批准号:
0957606 - 财政年份:2010
- 资助金额:
$ 49.03万 - 项目类别:
Continuing Grant
Catalytic C-H Amination with Late Metal Nitrenes and Amides
后金属氮烯和酰胺的催化 C-H 胺化
- 批准号:
1012523 - 财政年份:2010
- 资助金额:
$ 49.03万 - 项目类别:
Standard Grant
Catalytic Group Transfer with Late Metal Nitrenes
后金属氮烯的催化基团转移
- 批准号:
0716304 - 财政年份:2007
- 资助金额:
$ 49.03万 - 项目类别:
Continuing Grant
CAREER: Metal-Ligand Multiple Bonding in Later, First Row Complexes
事业:后来的第一行复合物中的金属-配体多重键合
- 批准号:
0135057 - 财政年份:2002
- 资助金额:
$ 49.03万 - 项目类别:
Continuing Grant
NSF NATO POSTDOCTORAL FELLOWSHIPS
NSF 北约博士后奖学金
- 批准号:
9710805 - 财政年份:1997
- 资助金额:
$ 49.03万 - 项目类别:
Fellowship Award
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