Catalytic C-H Amination with Late Metal Nitrenes and Amides

后金属氮烯和酰胺的催化 C-H 胺化

• 批准号: 1012523
• 负责人: Timothy Warren
• 金额: $ 43.5万
• 依托单位: Georgetown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012523&HistoricalAwards=false
• 关键词: Catalytic; Amination; Late; Metal; Nitrenes

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Timothy H. Warren of Georgetown University will develop catalytic carbon-hydrogen (C-H) amination reactions as a means of preparing new carbon-nitrogen (C-N) bonds without the need to pre-functionalize the reactive sites. The ability to directly affect the C-H to C-N transformation without the need to isolate, purify, and transform corresponding precursors offers the appealing prospect of reduced cost, energy consumption and environmental impact. Building on previous results, this approach connects the chemical and electronic structures of copper and nickel nitrene and amide complexes to their catalytic reactivity. The work specifically examines copper and nickel nitrene complexes derived from organoazides, the amine and substrate scope of the reactions, and new catalysts architectures to further enhance the efficiency and scope of the catalytic reactions. The broader impacts of this project include national and international collaborations that will expand the student's perspective on the way science is conducted within the larger scientific community. Professor Warren is active in mentoring high school students, undergraduates (especially through the NSF-sponsored REU program) and graduate students.This work will expand the repertoire of methods that can be used in the chemical synthesis of compounds containing C-N bonds. The results of these studies could have many important long term impacts on a variety of applications in synthetic and materials chemistry, particularly in medicinal or pharmaceutical products.

在这个由化学系化学催化计划资助的项目中，蒂莫西·H·乔治城大学的沃伦将开发催化碳氢（C-H）胺化反应，作为制备新的碳氮（C-N）键的一种手段，而不需要预先官能化反应位点。 直接影响C-H到C-N转化而不需要分离、纯化和转化相应前体的能力提供了降低成本、能量消耗和环境影响的吸引人的前景。 在以前的结果的基础上，这种方法将铜和镍氮烯和酰胺络合物的化学和电子结构与其催化反应性联系起来。 这项工作专门研究了来自有机叠氮化物的铜和镍氮烯络合物，反应的胺和底物范围，以及新的催化剂结构，以进一步提高催化反应的效率和范围。 该项目的更广泛的影响包括国家和国际合作，这将扩大学生对科学在更大的科学界进行的方式的看法。 Warren教授积极指导高中生、本科生（特别是通过NSF赞助的REU项目）和研究生。这项工作将扩大可用于含C-N键化合物化学合成的方法库。 这些研究的结果可能对合成和材料化学的各种应用产生许多重要的长期影响，特别是在医药产品中。