CAREER: Adaptation and learning processes in human locomotion

职业：人类运动的适应和学习过程

• 批准号: 2001222
• 负责人: Julia Choi
• 金额: $ 49.09万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2001222&HistoricalAwards=false
• 关键词: CAREER; Adaptation; learning; processes; human

Motor adaptation and learning is fundamental to the flexibility of walking. Our movement patterns must be constantly adapted as we grow, age, or experience changing conditions such as slippery sidewalks. Learning new motor skills initiates a process of memory formation that generated improved and more stable performance. Previously learned motor memories can also be used to learn another motor task more rapidly. The goal of this project is to reveal how the human brain creates and recalls memories in walking. This will be achieved by studying a set of tasks inspired by research of arm control. The expected findings will have broad implications for human walking flexibility in health and disease, because motor learning and rehabilitation are thought to share similar mechanisms. The advanced scientific knowledge will have broader impacts, including the possible transformation of gait rehabilitation approaches and enhanced understanding of learning and memory in the human brain. Further, this work includes interdisciplinary neuroscience training of promising students with diverse ethnic, gender, and academic backgrounds.The research objective of this CAREER proposal is to understand the mechanisms for human locomotor adaptation and learning. While motor learning has received ample attention in studies utilizing upper limbs, there are relatively few studies of motor learning in the context of human locomotion. These experiments will examine the commonalities as well as task-specific distinctions across different types of locomotor learning paradigms: sequence learning, visuomotor adaptation and dynamic (split-belt treadmill) adaptation. Specifically, this work will examine how consolidation leads to offline learning and resistance to interferences between different walking patterns, and the immediate and delayed benefits of variable practice on the generalization of learning. This research will also examine the role of sleep in consolidation and generalization of locomotor learning. The integrated educational plan will provide interdisciplinary neuroscience training to undergraduate and graduate students in order to develop and retain young scientists in the area of movement neuroscience. The project will promote active participation from underrepresented students in order to equip women and minorities to pursue STEM education. The project team will engage in public outreach and the dissemination of scientific progress to regional communities, to enhance general interest in science and technology amongst the public.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

运动适应和学习是行走灵活性的基础。随着我们的成长、变老或经历不断变化的环境（例如湿滑的人行道），我们的运动模式必须不断适应。学习新的运动技能会启动记忆形成过程，从而产生更好、更稳定的表现。先前学习的运动记忆也可用于更快地学习另一项运动任务。该项目的目标是揭示人脑如何在行走中创建和回忆记忆。这将通过研究一组受手臂控制研究启发的任务来实现。预期的发现将对人类在健康和疾病中行走的灵活性产生广泛的影响，因为运动学习和康复被认为具有相似的机制。先进的科学知识将产生更广泛的影响，包括可能改变步态康复方法以及增强对人脑学习和记忆的理解。此外，这项工作还包括对具有不同种族、性别和学术背景的有前途的学生进行跨学科神经科学培训。这项职业提案的研究目标是了解人类运动适应和学习的机制。虽然运动学习在利用上肢的研究中受到了足够的关注，但在人类运动背景下的运动学习研究相对较少。这些实验将检查不同类型运动学习范式的共性以及特定任务的区别：序列学习、视觉运动适应和动态（分带式跑步机）适应。具体来说，这项工作将研究巩固如何导致离线学习和抵抗不同步行模式之间的干扰，以及可变练习对学习泛化的直接和延迟的好处。这项研究还将探讨睡眠在巩固和推广运动学习中的作用。该综合教育计划将为本科生和研究生提供跨学科神经科学培训，以培养和留住运动神经科学领域的年轻科学家。该项目将促进代表性不足的学生积极参与，以使妇女和少数族裔能够接受 STEM 教育。项目团队将参与公共宣传活动，并向地区社区传播科学进步，以提高公众对科学技术的普遍兴趣。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Visuomotor errors drive step length and step time adaptation during ‘virtual’ split-belt walking: the effects of reinforcement feedback

视觉运动误差驱动“虚拟”分带行走过程中的步长和步时适应：强化反馈的影响

• DOI: 10.1007/s00221-021-06275-6
• 发表时间: 2022
• 期刊: Experimental Brain Research
• 影响因子: 2
• 作者: Sato, Sumire;Cui, Ashley;Choi, Julia T.
• 通讯作者: Choi, Julia T.

Reduced corticospinal drive and inflexible temporal adaptation during visually guided walking in older adults

• DOI: 10.1152/jn.00078.2023
• 发表时间: 2023-12-08
• 期刊: JOURNAL OF NEUROPHYSIOLOGY
• 影响因子: 2.5
• 作者: Sato，Sumire D.;Choi，Julia T.
• 通讯作者: Choi，Julia T.