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Collaborative Research: Experimental and Computational Studies of Flow and Clogging of Deformable Particles under Confinement

合作研究：约束下可变形颗粒流动和堵塞的实验和计算研究

基本信息

批准号：
2002797
负责人：
Mark Shattuck
金额：
$ 16.86万
依托单位：
CUNY City College
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2024-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2002797&HistoricalAwards=false
关键词：
Collaborative Research Experimental Computational Studies

项目摘要

Squishy, deformable particles play an important role in many fields of science and engineering, from the biological cells to droplets of fatty oils in water that make up emulsions like mayonnaise, peanut butter, and milk. Microfluidic devices with tiny channels of varying widths are used to process mixtures of deformable particles and fluids and to manipulate DNA molecules. However, microfluidic devices frequently clog near constrictions, which is expensive since the device must be replaced when this occurs. Clogging has been studied extensively for rigid particles, like grains flowing out of a silo, but clogging of deformable particles is less well understood. In particular, it is unclear how particle deformability and stickiness or cohesion affects clogging. For example, will deformable and cohesive particles change shape and flow past each other at constrictions, or will they form arches and clog the system? This project combines experiments of emulsion droplets flowed through microfluidic devices with novel computer simulations of deformable particles to understand how they clog. This work will aid in future designs of critical microfluidic devices involved in industrial processing, filtration, and analysis of biological samples of cell-fluid mixtures. Flow-induced jamming, or clogging, is observed across a wide range of systems, from flows of granular materials in silos to flows of blood cells through veins. Clogging is well studied in the case of hard, frictional grains, but is poorly understood when particles are deformable and cohesive. This project employs experiments of suspensions of emulsion droplets with tunable deformability and adhesion flowed through microfluidic devices, along with novel simulations of flows of explicitly deformable particles designed to model emulsion droplets. The combined experimental-computational approach can disentangle the effects of deformability, particle mechanical response, and adhesion on clogging probability. One key focus is the role of particle rearrangements during clogs in unjamming the suspensions. During clogs of granular materials, particles are static and clogs have long lifetimes. However, if particles are deformable, particle shape relaxation and stress redistribution in a clogged suspension can lead to intermittent clog release and avalanching. Additionally, this project will investigate how the Beverloo Law, which describes how flow rate changes with constriction width, changes in the case of deformable and adhesive particles. The combination of computational and experimental studies will aid the development of a comprehensive theoretical framework to predict when a clog will form given the particle properties, flow rate, and constriction width. With the increased use of microfluidic devices to analyze suspensions of colloidal particles and cells, a predictive framework for clogging based on single-particle properties like deformability, elasticity and adhesion is required to design the next generation of efficient high-throughput microfluidic devices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

软绵绵的、可变形的颗粒在许多科学和工程领域发挥着重要作用，从生物细胞到构成蛋黄酱、花生酱和牛奶等乳液的水中脂肪油滴。微流控装置具有不同宽度的微小通道，用于处理可变形颗粒和流体的混合物，以及操纵DNA分子。然而，微流体装置经常在收缩处附近堵塞，这是昂贵的，因为当这种情况发生时，必须更换装置。人们对刚性颗粒的堵塞进行了广泛的研究，比如从筒仓流出的颗粒，但对可变形颗粒的堵塞却知之甚少。特别是，目前尚不清楚颗粒的变形性和粘性或内聚性如何影响堵塞。例如，可变形和有凝聚力的颗粒会改变形状并在收缩时相互流动，还是会形成拱形并堵塞系统？本计画将乳化液液滴流过微流控装置的实验与可变形粒子的新型电脑模拟相结合，以了解它们如何堵塞。这项工作将有助于未来设计涉及工业处理、过滤和细胞-流体混合物生物样品分析的关键微流体装置。从筒仓中的粒状物质流动到静脉中的血细胞流动，在很多系统中都可以观察到由流动引起的干扰或堵塞。在坚硬的摩擦颗粒的情况下，堵塞得到了很好的研究，但在颗粒可变形和内聚的情况下，堵塞却知之甚少。本项目通过微流控装置对具有可调变形性和黏附性的乳化液液滴悬浮液进行实验，同时对可明显变形的颗粒流动进行新颖的模拟，以模拟乳化液液滴。实验-计算相结合的方法可以解开变形性、颗粒力学响应和粘附性对堵塞概率的影响。一个关键的焦点是粒子重排的作用，在堵塞过程中解除悬浮液的堵塞。在颗粒材料的堵塞过程中，颗粒是静态的，堵塞的寿命很长。然而，如果颗粒是可变形的，颗粒形状松弛和应力重新分布在堵塞的悬浮液中会导致间歇性的堵塞释放和雪崩。此外，该项目将研究Beverloo定律（描述流量如何随收缩宽度变化）在可变形颗粒和粘附颗粒情况下的变化。计算和实验研究的结合将有助于建立一个全面的理论框架，以预测在给定颗粒特性、流速和收缩宽度的情况下何时会形成堵塞。随着微流控设备越来越多地用于分析胶体颗粒和细胞的悬浮液，需要基于单颗粒特性（如可变形性、弹性和粘附性）的堵塞预测框架来设计下一代高效的高通量微流控设备。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Shear response of granular packings compressed above jamming onset

堵塞开始时压缩颗粒填料的剪切响应

DOI：
10.1103/physreve.103.022902
发表时间：
2021
期刊：
Physical Review E
影响因子：
2.4
作者：
Wang, Philip;Zhang, Shiyun;Tuckman, Philip;Ouellette, Nicholas T.;Shattuck, Mark D.;O'Hern, Corey S.
通讯作者：
O'Hern, Corey S.

Local and global measures of the shear moduli of jammed disk packings

卡住盘填料剪切模量的局部和全局测量

DOI：
10.1103/physreve.107.054903
发表时间：
2023
期刊：
Physical Review E
影响因子：
2.4
作者：
Zhang, Shiyun;Jin, Weiwei;Wang, Dong;Xu, Ding;Zhang, Jerry;Shattuck, Mark D.;O'Hern, Corey S.
通讯作者：
O'Hern, Corey S.

Bridging particle deformability and collective response in soft solids

桥接软固体中的颗粒变形性和集体响应

DOI：
10.1103/physrevmaterials.5.055605
发表时间：
2021
期刊：
Physical Review Materials
影响因子：
3.4
作者：
Treado, John D.;Wang, Dong;Boromand, Arman;Murrell, Michael P.;Shattuck, Mark D.;O'Hern, Corey S.
通讯作者：
O'Hern, Corey S.

Hopper flows of deformable particles

可变形颗粒的料斗流动

DOI：
10.1039/d2sm01079h
发表时间：
2022
期刊：
Soft Matter
影响因子：
3.4
作者：
Cheng, Yuxuan;Treado, John D.;Lonial, Benjamin F.;Habdas, Piotr;Weeks, Eric R.;Shattuck, Mark D.;O'Hern, Corey S.
通讯作者：
O'Hern, Corey S.