Hypervalent Iodine Based Materials

高价碘基材料

• 批准号: 2003654
• 负责人: Kyle Plunkett
• 金额: $ 45万
• 依托单位: Southern Illinois University at Carbondale
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2003654&HistoricalAwards=false
• 关键词: Hypervalent; Iodine; Based; Materials

With funding from the Macromolecular, Supramolecular, and Nanochemistry Program of the Chemistry Division, Professor Kyle N. Plunkett of Southern Illinois University at Carbondale is creating new supramolecular assemblies based on organic cyclic molecules that contain the chemical element iodine. Inspired by nature, supramolecular chemistry utilizes hydrogen bonding to dictate assemblies such as proteins, enzymes, and DNA. In this research, general strategies are developed to prepare building blocks for assemblies based on amino acids containing iodine fragments. These building blocks provide a framework for 3D structures that have applications in gas/molecular absorption and sensing. The bonding and properties are investigated using several experimental techniques. This project contributes to the training of a diverse group of students. The research team is designing 180-degree 3D videos of laboratory experiments and demonstrations. The video content is used with virtual reality headsets to immerse internet-connected learners in a virtual chemistry world. Outreach activities focus on recruitment of local high school students to participate in research stays over the summer, winter or spring breaks.This research is focused on developing new supramolecular assemblies based on hypervalent iodine macrocycles that are synthesized from amino acid functionalized benziodazoles. These molecules self-assemble through secondary bonding into macrocyclic structures, which are the building block for the higher order supramolecular structures including molecular cages and covalent organic frameworks. These macrostructures provide a framework to build molecular cages by linkages made through non-natural amino acid side chains. Specific goals of this work are to explore the dynamic covalent bonding of hypervalent iodine macrocycles and identify expedient synthetic routes towards molecular cages. The investigators also seek to quantify guest ion/molecule binding affinity, reaction-promoted disassembly and solid-state properties and characterize covalent organic frameworks based on hypervalent iodine macrocyclization reactions. This research provides new methods to guide supramolecular assemblies, which is of fundamental interest because of the new bonding and reactivity possibilities that could provide access to properties such as chiral recognition and reactivity. Additionally, potential impacts of this research include the design and synthesis of high surface area materials that have emerging properties for applications in gas/molecule absorption and sensing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系大分子、超分子和纳米化学项目的资助下，凯尔N.南伊利诺伊大学卡本代尔分校的普朗克特正在基于含有化学元素碘的有机环状分子创建新的超分子组装体。 受自然界的启发，超分子化学利用氢键来控制蛋白质、酶和DNA等组装体。 在这项研究中，一般的策略，以制备基于含碘片段的氨基酸组装的积木。 这些构建块为在气体/分子吸收和传感中具有应用的3D结构提供了框架。使用几种实验技术的键合和性能进行了研究。 该项目有助于培训不同的学生群体。 研究团队正在设计实验室实验和演示的180度3D视频。视频内容与虚拟现实耳机一起使用，使互联网连接的学习者沉浸在虚拟的化学世界中。 外展活动的重点是招募当地高中生在暑假、寒假或春假期间参加研究停留。这项研究的重点是开发基于高价碘大环的新型超分子组装体，该大环由氨基酸官能化的苯并碘唑合成。 这些分子通过次级键合自组装成大环结构，大环结构是包括分子笼和共价有机框架的高级超分子结构的构建单元。 这些宏观结构提供了一个框架，通过非天然氨基酸侧链形成的连接来构建分子笼。 这项工作的具体目标是探索动态共价键合的高价碘大环化合物，并确定有利的合成路线走向分子笼。 研究人员还试图量化客体离子/分子结合亲和力，反应促进的分解和固态性质，并基于高价碘大环化反应表征共价有机框架。 这项研究提供了新的方法来指导超分子组装，这是根本的利益，因为新的键合和反应的可能性，可以提供访问的性质，如手性识别和反应性。 此外，这项研究的潜在影响包括设计和合成高表面积材料，这些材料具有用于气体/分子吸收和传感的新兴特性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。