Bioinspired Soft Materials

仿生软材料

• 批准号: 2011846
• 负责人: Aparna Baskaran
• 金额: $ 1800万
• 依托单位: Brandeis University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2011846&HistoricalAwards=false
• 关键词: Bioinspired; Soft; Materials

Nontechnical Abstract: The Brandeis Bioinspired Soft Materials Research Science and Engineering Center (MRSEC) seeks to engineer new materials that capture the remarkable functionalities found in living organisms. To realize this vision the Center synergistically focuses on two topics at the forefront of Soft Materials research. The first, Self-Limiting Assembly, adopts a bioinspired approach to develop a suite of building blocks which undergo equilibrium self-assembly that terminates at a prescribed finite-size. Learning to engineer self-limiting structures is enabling the scalable design of new functional and adaptable materials, such as paintable photonic coatings and capsids for drug therapy including general strategies to deactivate virus infection, including covid-19. The second, Soft Active Materials, is inspired by the remarkable capabilities of living cells, with their abilities to sense, self-heal and move. This MRSEC is establishing the principles to design, measure and control the forces in active materials to generate rapidly reconfigurable life-like materials, with applications in fields as diverse as robotics, microfluidics and adaptive optics. The MRSEC emphasizes human resource development for the STEM workforce. To facilitate this is the MRSEC’s SciComm Lab comprising science graduate students and postdocs trained to become effective communicators and peer mentors. These SciComm Lab mentors train their peers in the skills they need to communicate their science to disparate audiences ranging from future employers to a diverse, non-scientific public. The Path-to-Professorship Program, aimed at providing superior postdoctoral fellow training for underrepresented minorities in cutting-edge materials research and designed to prepare individuals for assuming full-time faculty positions.Technical Abstract: The Brandeis Bioinspired Soft Materials Research Science and Engineering Center (MRSEC)is engineering new materials that capture the remarkable functionalities found in living organisms. The Center is organized into two Interdisciplinary Research Groups (IRG). IRG1, Self-Limiting Assembly, addresses a grand challenge in soft materials science, the self-assembly of complex and functional materials. While living systems routinely achieve size-controlled assembly, synthetic approaches lag far behind. IRG1 adopts a bioinspired approach to develop a suite of building blocks which undergo equilibrium self-assembly that self-terminates at a prescribed finite-size. Learning to engineer self-limiting structures is enabling scalable design of new functional and adaptable materials, such as paintable photonic coatings and capsids for drug and gene therapy. IRG2, Soft Active Materials, is inspired by the remarkable capabilities of living cells, such as crawling, reconfiguring, and regenerating which are driven by energy-consuming molecular motors. An unmet grand challenge is to construct artificial active materials with active stresses designed to produce a desired function. This is leading to the next generation of active materials that are robust and exhibit long-lived programmable dynamics, thus paving the way to applications. This MRSEC emphasizes human resource development for the STEM workforce. To facilitate this is the MRSEC's SciComm Lab comprising science graduate students and postdocs trained to become effective communicators and peer mentors. The Path-to-Professorship Program, aimed at providing superior postdoctoral fellow training for underrepresented minorities in cutting-edge materials research and designed to prepare individuals for assuming full-time faculty positions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要：Brandeis Bioinspired Soft Materials Research Science and Engineering Center（MRSEC）致力于设计新材料，以捕捉生物体中发现的卓越功能。为了实现这一愿景，该中心协同专注于软材料研究前沿的两个主题。第一个，自限性组装，采用生物启发的方法来开发一套积木，进行平衡自组装，终止于规定的有限大小。学习设计自限性结构，使新型功能性和适应性材料的可扩展设计成为可能，例如可着色的光子涂层和用于药物治疗的衣壳，包括灭活病毒感染（包括新冠病毒）的一般策略。第二个是软活性材料，灵感来自活细胞的非凡能力，它们具有感知，自我修复和移动的能力。该MRSEC正在建立设计，测量和控制活性材料中的力的原则，以生成快速可重构的类生命材料，并在机器人，微流体和自适应光学等领域应用。MRSEC强调STEM劳动力的人力资源开发。为了促进这一点，MRSEC的SciComm实验室由科学研究生和博士后组成，他们经过培训成为有效的沟通者和同行导师。这些SciComm实验室导师培训他们的同行，使他们能够向不同的受众（从未来的雇主到多样化的非科学公众）传达他们的科学所需的技能。该途径教授计划，旨在提供上级博士后研究员培训，为代表性不足的少数民族在尖端材料研究，并旨在准备个人承担全职教师职位。技术摘要：布兰代斯生物启发软材料研究科学与工程中心（MRSEC）是工程新材料，捕捉在活生物体中发现的显着功能。该中心分为两个跨学科研究小组（IRG）。IRG1，自限性组装，解决了软材料科学中的一个重大挑战，即复杂功能材料的自组装。虽然生命系统通常实现大小控制的组装，但合成方法远远落后。IRG1采用生物启发的方法来开发一套积木，这些积木经历平衡自组装，并在规定的有限尺寸下自终止。学习设计自限性结构使新功能和适应性材料的可扩展设计成为可能，例如用于药物和基因治疗的可着色光子涂层和衣壳。IRG2，软活性材料，灵感来自活细胞的非凡能力，如爬行，重组和再生，这些都是由耗能分子马达驱动的。一个尚未满足的巨大挑战是构建具有设计用于产生期望功能的主动应力的人工活性材料。这将导致下一代活性材料的产生，这些材料具有耐用性和长寿命的可编程动态特性，从而为应用铺平了道路。该MRSEC强调STEM劳动力的人力资源开发。为了促进这一点，MRSEC的SciComm实验室由科学研究生和博士后组成，他们经过培训成为有效的沟通者和同行导师。通往教授职位的道路计划，旨在为代表性不足的少数民族提供尖端材料研究方面的上级博士后研究员培训，旨在为个人担任全职教师职位做好准备。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Optimization of non-equilibrium self-assembly protocols using Markov state models

使用马尔可夫状态模型优化非平衡自组装协议

• DOI: 10.1063/5.0130407
• 发表时间: 2022
• 期刊: The Journal of Chemical Physics
• 作者: Trubiano, Anthony;Hagan, Michael F.
• 通讯作者: Hagan, Michael F.

Engineering Metastability into a Virus-like Particle to Enable Triggered Dissociation

• DOI: 10.1021/jacs.2c10937
• 发表时间: 2023-01-18
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Starr，Caleb A.;Nair，Smita;Zlotnick，Adam
• 通讯作者: Zlotnick，Adam

Multiscale Modeling of Hepatitis B Virus Capsid Assembly and Its Dimorphism.

• DOI: 10.1021/acsnano.2c02119
• 发表时间: 2022-09-27
• 期刊: ACS NANO
• 影响因子: 17.1
• 作者: Mohajerani, Farzaneh;Tyukodi, Botond;Schlicksup, Christopher J.;Hadden-Perilla, Jodi A.;Zlotnick, Adam;Hagan, Michael F.
• 通讯作者: Hagan, Michael F.

An approach for quantitative mapping of synaptic periactive zone architecture and organization.

• DOI: 10.1091/mbc.e22-08-0372
• 发表时间: 2023-05-15
• 期刊: MOLECULAR BIOLOGY OF THE CELL
• 影响因子: 3.3
• 作者: Del Signore, Steven J.;Mitzner, Margalit G.;Silveira, Anne M.;Fai, Thomas G.;Rodal, Avital A.
• 通讯作者: Rodal, Avital A.