Collaborative Research: Data-Driven Variational Multiscale Reduced Order Models for Biomedical and Engineering Applications

协作研究：用于生物医学和工程应用的数据驱动的变分多尺度降阶模型

• 批准号: 2012686
• 负责人: Alessandro Veneziani
• 金额: $ 22.62万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2012686&HistoricalAwards=false
• 关键词: Collaborative; Research; Data; Driven; Variational

Mathematical models are a fundamental tool for improving our knowledge of natural and industrial processes. Their use in practice depends on their reliability and efficiency. Reliability requires a fine-tuning of the model parameters and an accurate assessment of the sensitivity to noisy inputs. Efficiency is particularly critical in optimization problems, where the computational procedure identifies the best working conditions of a complex system. These requirements lead to solving many times models with millions or even billions of unknowns. This process may require days or weeks of computations on high-performance computing facilities. To mitigate these costs, we need new modeling strategies that allow model-runs in minutes to hours on local computing facilities (such as a laptop). Reduced order models (ROMs) are extremely low-dimensional approximations that can decrease the computational cost of current computational models by orders of magnitude. Having in mind biomedical and wind-engineering applications, this project proposes novel methods of model reduction. Data and numerical results from the expensive (or high-fidelity) models are combined with machine learning approaches, to obtain ROMs that attain both efficiency and accuracy at an unprecedented level. The new data-driven ROM framework will finally make possible the numerical simulation of aortic dissections, pediatric surgery, or wind farm optimization on a laptop in minutes, and aims at becoming a critical and trustworthy tool in decision-making processes.Data assimilation (DA), uncertainty quantification (UQ), and shape optimization (SO) are central to the development of computational models for significant biomedical and engineering applications. Since these applications require a large number of model simulations, running an expensive full order model (FOM) is generally prohibitively expensive. For systems that display dominant structures, reduced order models (ROMs) can decrease the FOM computational cost by orders of magnitude. Thus, for the clinical and engineering applications above, ROMs appear as a natural and practical alternative to the prohibitively expensive FOMs running on high-performance computing facilities. Unfortunately, to capture all the geometric scales in the hemodynamics of aortic dissections or to cope with the large Reynolds number in the wind farm optimization, hundreds and thousands of ROM modes are necessary. These relatively high-dimensional ROMs are still not viable to effectively perform DA, UQ, or SO for these applications. What is needed is ROMs that are not only low-dimensional and efficient, but also accurate. To develop ROMs that are accurate in realistic, under-resolved regimes, the ROM closure problem needs to be solved, i.e., the effect of the discarded ROM modes on the ROM dynamics needs to be modeled. The proposed research puts forth a new data-driven ROM paradigm that centers around the hierarchical structure of variational multiscale (VMS) methodology and utilizes modern machine learning (ML) and numerical and observational data to develop structural ROM closures that can dramatically increase the ROM accuracy at a modest computational cost. The novel data-driven VMS-ROM paradigm maintains the low computational cost of current ROMs but dramatically increases the ROM accuracy. Biomedical applications in thoracic and pediatric surgery (aortic dissections and Fontan procedure – where the fate of the patient depends significantly on the shape of the vessels) as well as wind-engineering applications are specifically targeted. The data-driven VMS-ROM framework will finally make possible the efficient DA, UQ, and SO in these and, possibly, other fields relying on mathematical and computational modeling. This project will support one graduate student each year at each of the three institutions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

数学模型是提高我们对自然和工业过程的认识的基本工具。它们在实践中的使用取决于它们的可靠性和效率。可靠性要求对模型参数进行微调，并准确评估对噪声输入的灵敏度。效率在优化问题中尤其重要，其中计算过程确定复杂系统的最佳工作条件。 这些要求导致求解具有数百万甚至数十亿未知量的多次模型。这一过程可能需要在高性能计算设施上进行数天或数周的计算。为了降低这些成本，我们需要新的建模策略，允许在本地计算设备（如笔记本电脑）上在几分钟到几小时内运行模型。 降阶模型（ROM）是一种极低维的近似，可以将当前计算模型的计算成本降低几个数量级。考虑到生物医学和风力工程的应用，该项目提出了新的模型简化方法。来自昂贵（或高保真）模型的数据和数值结果与机器学习方法相结合，以获得在前所未有的水平上实现效率和准确性的ROM。新的数据驱动ROM框架最终将使主动脉夹层、儿科手术或风电场优化的数值模拟在笔记本电脑上在几分钟内成为可能，并旨在成为决策过程中关键和值得信赖的工具。数据同化（DA），不确定性量化（UQ），和形状优化（SO）是重要的生物医学和工程应用的计算模型的发展的核心。 由于这些应用需要大量的模型仿真，运行昂贵的全阶模型（FOM）通常是非常昂贵的。 对于显示主导结构的系统，降阶模型（ROM）可以将FOM计算成本降低几个数量级。 因此，对于上述临床和工程应用，ROM似乎是在高性能计算设施上运行的昂贵FOM的自然和实用的替代品。 不幸的是，为了捕获主动脉夹层的血流动力学中的所有几何尺度，或者为了科普风电场优化中的大雷诺数，需要成百上千的ROM模式。这些相对高维的ROM仍然不能有效地为这些应用执行DA、UQ或SO。 所需要的是不仅是低维和高效的，而且是准确的ROM。 为了开发在现实的、欠分辨的状态下准确的ROM，需要解决ROM闭合问题，即，需要对丢弃的ROM模式对ROM动态特性的影响进行建模。 拟议的研究提出了一种新的数据驱动的ROM范式，该范式围绕变分多尺度（VMS）方法的层次结构，并利用现代机器学习（ML）以及数值和观测数据来开发结构ROM闭包，可以以适度的计算成本显着提高ROM的准确性。 新的数据驱动的VMS-ROM范例保持了当前ROM的低计算成本，但大大提高了ROM的精度。 特别针对胸外科和儿科手术中的生物医学应用（主动脉夹层和Fontan手术-患者的命运在很大程度上取决于血管的形状）以及风力工程应用。数据驱动的VMS-ROM框架最终将使这些领域以及其他依赖数学和计算建模的领域中的有效DA、UQ和SO成为可能。该项目每年将资助三个机构的一名研究生。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。