High Pressure Small Angle X-ray Scattering Workshop

地球上微生物生物量的很大一部分存在于深海和地下，但人们对高静水压力下生命的分子机制知之甚少。这次研讨会的目的是通过将深度生命生物学、极端生物物理学、结构生物学和X射线仪器的研究人员聚集在一起，促进新的跨学科努力来解决这个问题。研讨会将在康奈尔大学举行，该大学是康奈尔高能同步加速器源新运行的高压生物光束线(HP-BIO)的所在地。所涵盖的主题将假定没有X射线方法的先验知识，并将向高压结构生物学引入新的小组。讲习班将提供独特的教育机会，提供为期两天的关于小角X射线散射(SAXS)数据分析和高压SAXS数据收集的实践教程。思想和技能的交叉培养将通过一个由不同专家组成的科学项目来促进。将鼓励年轻科学家、代表性不足群体的成员和这一不断增长的领域的新科学家参与，并将优先考虑学生、博士后和其他早期职业研究人员。极端微生物在我们的环境中发挥着关键作用，具有独特的能力，具有可再生能源和生物技术应用的潜力。这些生物还为理解生命如何起源于我们的星球以及可能存在于我们太阳系的其他地方提供了一个框架。本次研讨会由生物科学局分子和细胞生物科学部的分子生物物理学计划和数学和物理科学局物理部的生命系统物理学计划资助。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

A significant fraction of the microbial biomass on Earth is found in the deep sea and subsurface, yet remarkably little is known about the molecular mechanisms of life under high hydrostatic pressures. This workshop aims to catalyze new interdisciplinary efforts to address this problem by bringing together researchers in deep life biology, extreme biophysics, structural biology, and X-ray instrumentation. The workshop will take place at Cornell University, which is home to the newly operational high-pressure biology beamlines (HP-Bio) at the Cornell High Energy Synchrotron Source. Topics covered will presume no prior knowledge of X-ray methods and will introduce new groups to high-pressure structural biology. The workshop will provide unique educational opportunities with two days of hands-on tutorials on small-angle X-ray scattering (SAXS) data analysis and high-pressure SAXS data collection. Cross-fertilization of ideas and skills will be promoted by a scientific program featuring a diverse group of experts. The participation of young scientists, members of underrepresented groups, and scientists who are new to this growing field will be encouraged and preference will be given to students, postdocs, and other early career investigators. Extremophiles play critical roles in our environment and possess unique abilities with potential for renewable energy and biotechnology applications. These organisms also provide a framework for understanding of how life may have originated on our planet and may exist elsewhere in our solar system. This workshop is funded by the Molecular Biophysics Program in the Division of Molecular and Cellular Biosciences in the Biological Sciences Directorate and the Physics of Living Systems Program in the Division of Physics in the Mathematical and Physical Sciences Directorate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.