High Pressure Small Angle X-ray Scattering Workshop

高压小角X射线散射车间

• 批准号: 2014954
• 负责人: Catherine Royer
• 金额: $ 9.8万
• 依托单位: Rensselaer Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2014954&HistoricalAwards=false
• 关键词: Pressure; Small; Angle; ray; Scattering

A significant fraction of the microbial biomass on Earth is found in the deep sea and subsurface, yet remarkably little is known about the molecular mechanisms of life under high hydrostatic pressures. This workshop aims to catalyze new interdisciplinary efforts to address this problem by bringing together researchers in deep life biology, extreme biophysics, structural biology, and X-ray instrumentation. The workshop will take place at Cornell University, which is home to the newly operational high-pressure biology beamlines (HP-Bio) at the Cornell High Energy Synchrotron Source. Topics covered will presume no prior knowledge of X-ray methods and will introduce new groups to high-pressure structural biology. The workshop will provide unique educational opportunities with two days of hands-on tutorials on small-angle X-ray scattering (SAXS) data analysis and high-pressure SAXS data collection. Cross-fertilization of ideas and skills will be promoted by a scientific program featuring a diverse group of experts. The participation of young scientists, members of underrepresented groups, and scientists who are new to this growing field will be encouraged and preference will be given to students, postdocs, and other early career investigators. Extremophiles play critical roles in our environment and possess unique abilities with potential for renewable energy and biotechnology applications. These organisms also provide a framework for understanding of how life may have originated on our planet and may exist elsewhere in our solar system. This workshop is funded by the Molecular Biophysics Program in the Division of Molecular and Cellular Biosciences in the Biological Sciences Directorate and the Physics of Living Systems Program in the Division of Physics in the Mathematical and Physical Sciences Directorate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在深海和地下发现了地球上微生物生物量的很大一部分，但对于高静水压力下的生命的分子机制知之甚少。该研讨会旨在通过将研究人员汇集到深层生命生物学，极端生物物理学，结构生物学和X射线仪器中，以促进新的跨学科努力来解决这一问题。该研讨会将在康奈尔大学举行，康奈尔大学是康奈尔高能同步源的新运营高压生物学束线（HP-BIO）的所在地。涵盖的主题将不认为X射线方法的先验知识，并且会将新小组引入高压结构生物学。 该研讨会将提供独特的教育机会，并提供两天的小型角度X射线散射（SAXS）数据分析和高压SAXS数据收集的动手教程。思想和技能的交叉利用将由一个科学计划促进，其中包括一系列专家。将鼓励年轻的科学家，代表性不足的群体成员以及新成长领域的科学家的参与，并将偏爱学生，博士后和其他早期职业调查员。极端粒子在我们的环境中起关键作用，并具有具有可再生能源和生物技术应用的独特能力。这些生物还提供了一个框架，以了解生命如何起源于我们的星球，并可能存在于我们的太阳系中的其他地方。该研讨会由生物学科学局分子和细胞生物科学的分子分子生物物理学计划资助，在数学和物理科学局的物理学部中，生命系统计划的物理计划资助。该奖项反映了NSF的法定任务，并通过评估了基础的范围，并通过评估了基金会的范围。