NRT-URoL: Molecular Probes and Sensors for Complex Environments

NRT-URoL：适用于复杂环境的分子探针和传感器

• 批准号: 2022168
• 负责人: Victoria DeRose
• 金额: $ 300万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2022168&HistoricalAwards=false
• 关键词: NRT; URoL; Molecular; Probes; Sensors

NRT-URoL: Molecular Probes and Sensors for Complex EnvironmentsComplex chemical and physical mixtures influence important processes related to agriculture, technology, and human health. This National Science Foundation Research Traineeship award to the University of Oregon will address the central challenge of developing molecular sensors and probes that are needed to understand these processes and address complex problems in biology and the environment. The project will support a unique program for graduate Master’s and PhD students that will provide training in the scientific areas of molecular probes and sensors, technological development, and data analysis. When combined, these areas will generate new methods of detecting and controlling small molecules in complex media. This program will also prepare graduate students to enter a challenging, changing future with a training plan that combines market-aligned research and innovation training, inclusive leadership practices, and immersive team-led projects. A total of 150 Master’s and PhD students will be involved in the program, including 25 NSF-supported PhD students. The combination of elements in this training program will produce a cohort of scientists who are uniquely prepared to address societal needs in diverse and dynamic workforce environments. This project will catalyze research to solve complex problems in environmental and life sciences arenas by developing synthetic molecular probes and novel devices. Major themes include: (a) Molecular sensors for analytes in complex environments; implantable chemFET sensors for regenerative biology; autonomous, self-contained sensors for real-time environmental monitoring; (b) Chemical tools for interrogating biological processes, including novel carbon nanohoops for multiplexed and multimodal biological imaging and multiplexed approaches to address the roles of reactive sulfur species in biology. Each of these themes brings together synthetic chemistry, sensing and detection, and analysis of complex data, all of which will be supported by the training environment. Trainees in this program will participate in a professional development series focusing on inclusive practices necessary to succeed in a diverse collaborative environment. Scientific and technical skills will be provided through targeted modules on chemical biology, device synthesis, biological models, and data analysis, as well as mentored ‘immersion laboratories’ designed in collaboration with industrial partners. In addition, all trainees will participate in a Lens of the Market professional development program that provides a mechanism to align fundamental science with market needs, provide strong professional development, and launch student careers. Successful elements of the NRT, as identified through rigorous evaluation, will be institutionalized at UO and shared with the broader academic community to provide a model for translating this training program to other disciplines or research areas. ……………………. The NSF Research Traineeship (NRT) Program is designed to encourage the development and implementation of bold, new potentially transformative models for STEM graduate education training. The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary or convergent research areas through comprehensive traineeship models that are innovative, evidence-based, and aligned with changing workforce and research needs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NRT-URoL：用于复杂环境的分子探针和传感器复杂的化学和物理混合物影响着与农业、技术和人类健康相关的重要过程。这项授予俄勒冈州大学的国家科学基金会研究培训计划将解决开发分子传感器和探针的核心挑战，这些传感器和探针是了解这些过程并解决生物学和环境中的复杂问题所必需的。该项目将为硕士和博士研究生提供一个独特的计划，该计划将提供分子探针和传感器，技术开发和数据分析等科学领域的培训。当这些领域结合起来时，将产生在复杂介质中检测和控制小分子的新方法。该计划还将为研究生进入一个充满挑战，不断变化的未来做好准备，其培训计划结合了市场导向的研究和创新培训，包容性的领导实践以及沉浸式的团队领导项目。共有150名硕士和博士生将参与该计划，其中包括25名NSF支持的博士生。该培训计划中的要素组合将产生一批科学家，他们为解决多样化和动态劳动力环境中的社会需求做好了独特的准备。该项目将通过开发合成分子探针和新型设备来促进研究，以解决环境和生命科学领域的复杂问题。主要主题包括：（a）用于复杂环境中分析物的分子传感器;用于再生生物学的植入式chemFET传感器;用于实时环境监测的自主自足式传感器;（B）用于询问生物过程的化学工具，包括用于多路复用和多模式生物成像的新型碳纳米环以及用于解决活性硫物质在生物学中的作用的多路复用方法。每个主题都汇集了合成化学，传感和检测以及复杂数据的分析，所有这些都将得到培训环境的支持。该计划的学员将参加一个专业发展系列，重点是在多样化的协作环境中取得成功所必需的包容性实践。科学和技术技能将通过化学生物学，设备合成，生物模型和数据分析的目标模块提供，以及与工业合作伙伴合作设计的指导“浸入式实验室”。此外，所有学员将参加市场专业发展计划的透镜，该计划提供了一种机制，使基础科学与市场需求保持一致，提供强大的专业发展，并启动学生的职业生涯。通过严格的评估确定的NRT的成功要素将在UO制度化，并与更广泛的学术界分享，以提供将此培训计划转化为其他学科或研究领域的模式。……………………. NSF研究培训（NRT）计划旨在鼓励为STEM研究生教育培训开发和实施大胆的，新的潜在变革模式。该计划致力于通过创新的、基于证据的、与不断变化的劳动力和研究需求相一致的综合培训模式，在高优先级的跨学科或融合研究领域对STEM研究生进行有效培训。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Thiol-Activated 1,2,4-Thiadiazolidin-3,5-diones Release Hydrogen Sulfide through a Carbonyl-Sulfide-Dependent Pathway.

• DOI: 10.1021/acs.joc.2c01220
• 发表时间: 2022-09-16
• 期刊: JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 3.6
• 作者: Smith, Haley M.;Pluth, Michael D.
• 通讯作者: Pluth, Michael D.

Influence of Ring Modifications on Nucleolar Stress Caused by Oxaliplatin‐Like Compounds**

环修饰对奥沙利铂类似化合物引起的核仁应力的影响**

• DOI: 10.1002/cbic.202200130
• 发表时间: 2022
• 期刊: ChemBioChem
• 影响因子: 3.2
• 作者: McDevitt, Christine E.;Guerrero, Andres S.;Smith, Haley M.;DeRose, Victoria J.
• 通讯作者: DeRose, Victoria J.

Expanding the Scope of Pnictogen‐Assisted Cyclophane Self‐Assembly

扩大 Pnictogen 的范围——辅助环芳自组装

• DOI: 10.1002/ejoc.202200056
• 发表时间: 2022
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Shear, Trevor A.;Mayhugh, Jacob T.;Zocchi, Luca J.;Demachkie, Isabella S.;Trubenstein, Henry J.;Zakharov, Lev N.;Johnson, Darren W.
• 通讯作者: Johnson, Darren W.