NRT-URoL: Molecular Probes and Sensors for Complex Environments

复杂环境的分子探针和传感器复杂的化学和物理混合物影响着与农业、技术和人类健康相关的重要过程。这项授予俄勒冈大学的国家科学基金会研究培训奖将解决开发分子传感器和探针的核心挑战，这些传感器和探针需要理解这些过程，并解决生物学和环境中的复杂问题。该项目将为研究生和博士生提供一个独特的项目，该项目将在分子探针和传感器、技术开发和数据分析等科学领域提供培训。当这些领域结合在一起时，将产生检测和控制复杂介质中的小分子的新方法。该项目还将通过结合市场研究和创新培训、包容性领导实践和沉浸式团队领导项目的培训计划，为研究生进入一个充满挑战和变化的未来做好准备。共有150名硕士生和博士生将参与该项目，其中包括25名nsf资助的博士生。该培训计划的要素组合将培养出一批科学家，他们在多样化和动态的劳动力环境中为解决社会需求做好了独特的准备。该项目将通过开发合成分子探针和新型设备，催化研究解决环境和生命科学领域的复杂问题。主要主题包括：(a)复杂环境中分析物的分子传感器；用于再生生物学的植入式化学场效应晶体管传感器；用于实时环境监测的自主、独立传感器；(b)用于询问生物过程的化学工具，包括用于多路和多模态生物成像的新型碳纳米环和用于解决活性硫物种在生物学中的作用的多路方法。这些主题中的每一个都汇集了合成化学、传感和检测以及复杂数据的分析，所有这些都将得到培训环境的支持。该项目的学员将参加一系列专业发展课程，重点关注在多元化合作环境中取得成功所必需的包容性实践。科学和技术技能将通过化学生物学、设备合成、生物模型和数据分析的目标模块，以及与工业伙伴合作设计的指导“浸入式实验室”来提供。此外，所有学员都将参加“市场视角”专业发展计划，该计划提供了一种机制，将基础科学与市场需求结合起来，提供强大的专业发展，并启动学生的职业生涯。通过严格评估确定的NRT的成功要素将在UO制度化，并与更广泛的学术界分享，为将该培训计划转化为其他学科或研究领域提供一个模型。.........................美国国家科学基金会研究实习生（NRT）计划旨在鼓励开发和实施大胆的、具有潜在变革性的STEM研究生教育培训新模式。该项目致力于通过创新、循证、适应不断变化的劳动力和研究需求的综合培训模式，在高优先级跨学科或融合研究领域对STEM研究生进行有效培训。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

NRT-URoL: Molecular Probes and Sensors for Complex EnvironmentsComplex chemical and physical mixtures influence important processes related to agriculture, technology, and human health. This National Science Foundation Research Traineeship award to the University of Oregon will address the central challenge of developing molecular sensors and probes that are needed to understand these processes and address complex problems in biology and the environment. The project will support a unique program for graduate Master’s and PhD students that will provide training in the scientific areas of molecular probes and sensors, technological development, and data analysis. When combined, these areas will generate new methods of detecting and controlling small molecules in complex media. This program will also prepare graduate students to enter a challenging, changing future with a training plan that combines market-aligned research and innovation training, inclusive leadership practices, and immersive team-led projects. A total of 150 Master’s and PhD students will be involved in the program, including 25 NSF-supported PhD students. The combination of elements in this training program will produce a cohort of scientists who are uniquely prepared to address societal needs in diverse and dynamic workforce environments. This project will catalyze research to solve complex problems in environmental and life sciences arenas by developing synthetic molecular probes and novel devices. Major themes include: (a) Molecular sensors for analytes in complex environments; implantable chemFET sensors for regenerative biology; autonomous, self-contained sensors for real-time environmental monitoring; (b) Chemical tools for interrogating biological processes, including novel carbon nanohoops for multiplexed and multimodal biological imaging and multiplexed approaches to address the roles of reactive sulfur species in biology. Each of these themes brings together synthetic chemistry, sensing and detection, and analysis of complex data, all of which will be supported by the training environment. Trainees in this program will participate in a professional development series focusing on inclusive practices necessary to succeed in a diverse collaborative environment. Scientific and technical skills will be provided through targeted modules on chemical biology, device synthesis, biological models, and data analysis, as well as mentored ‘immersion laboratories’ designed in collaboration with industrial partners. In addition, all trainees will participate in a Lens of the Market professional development program that provides a mechanism to align fundamental science with market needs, provide strong professional development, and launch student careers. Successful elements of the NRT, as identified through rigorous evaluation, will be institutionalized at UO and shared with the broader academic community to provide a model for translating this training program to other disciplines or research areas. ……………………. The NSF Research Traineeship (NRT) Program is designed to encourage the development and implementation of bold, new potentially transformative models for STEM graduate education training. The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary or convergent research areas through comprehensive traineeship models that are innovative, evidence-based, and aligned with changing workforce and research needs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.