STAT6-regulated B cell responses in type 2 immunity (20)

已知转录因子STAT6是免疫球蛋白类转化为IgE所必需的。此外，project 20发现了STAT6在B细胞中调控2型免疫生发中心（GC）反应的关键作用，并通过组合蛋白质组/转录组进一步鉴定了B细胞中众多STAT6调控基因。此外，本项目可以证明IgE- bcr的免疫酪氨酸尾基序对于IgE+浆细胞（PCs）的扩增是必需的。在下一个资助期，该项目将确定不同的stat6调控基因在GC形成中的作用，表征蠕虫来源的B细胞抗原，并通过GC来源细胞的命运定位监测记忆B细胞和长寿命pc的发育。

The transcription factor STAT6 is known to be required for immunoglobulin class switching to IgE. In addition, project 20 found a critical role of STAT6 in B cells for regulation of the germinal center (GC) reaction in type 2 immunity and further identified numerous STAT6-regulated genes in B cells by a combined proteome/transcriptome. In addition, this project could show that the immunotyrosine tail motif of the IgE-BCR was required for expansion of IgE+ plasma cells (PCs). In the next funding period this project will determine the role of distinct STAT6-regulated genes for GC formation, characterize helminth-derived B cell antigens and monitor the development of memory B cells and long-lived PCs by fate mapping of GC-derived cells.