CCI Phase I: NSF Center for Chemistry with Electric Fields (ChEF)

CCI 第一阶段：NSF 电场化学中心 (ChEF)

• 批准号: 2023568
• 负责人: Latha Venkataraman
• 金额: $ 180万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2023568&HistoricalAwards=false
• 关键词: CCI; Phase; NSF; Center; Chemistry

The NSF Center for Chemistry with Electric Fields (ChEF) is supported by the Centers for Chemical Innovation (CCI) Program of the Division of Chemistry. This Phase I Center is led by Latha Venkataraman of Columbia University. Other team members are also from Columbia and include Timothy Berkelbach, Colin Nuckolls, Tomislav Rovis, and Xavier Roy. The challenge of this center is to use directional electric fields to understand, control and manipulate chemical transition states to alter the outcomes of chemical reactions. New techniques are developed to expand the range of reactions that can be controlled and manipulated by electric fields. The strategy of bringing together team members with expertise in synthesis, measurement, and computation augers well for the Center's goal of controlling and inducing new chemical pathways, accelerating catalysis, and generating a new paradigm for organic synthesis. The bold goal of this team is to electric field control such that structures, pathways, and intermediates that are not possible or practical with traditional chemical catalysis become so. Broader impacts are addressed in part through strong collaborations with Merck and Columbia Technology Ventures. Students have opportunities for self-governance and professional development. Students are co-mentored and undergraduates are included in the team. The team partners with the Harlem Children’s Zone School in New York to broaden the participation of chemistry to K-12 underrepresented groups. Development of a Chemistry Magic Show and Subway Science and Engineering address the expectations for informal science communication. The NYC location of the Phase I team provides ready access to a population that is underrepresented in STEM. The aim of this Phase I Center is to understand, control and manipulate chemical reactions utilizing electric fields. These electric fields can originate from an external bias produced using nanoscale electrode gaps or from strategically placed charges within a catalyst. Altering transition states by an external bias is the ultimate demonstration of controlling matter away from equilibrium and toward desired reactivity. This research charts a path to controlling the environment and electric field around reaction centers to accelerate desired reactivity and selectivity, developing reaction pathways and outcomes that are otherwise inaccessible by altering reaction kinetics and thermodynamics. The CCI team combines expertise in synthesis, measurement and computation and works in two interdisciplinary research thrusts, focused on two families of reactions: (1) Isomerization and Pericyclic Reactions, and (2) Coupling Reactions. This work aims to provide a mechanistic and quantitative understanding of how electric fields can control reactions while developing routes to alter selectivity and rates in a range of reactions including the Claisen rearrangement, the Diels Alder cycloaddition, and bond activation of carbon-halogen, metal-heteroatom and carbon-carbon bonds. Chemistry is at the center of the nanoscience revolution and this proposal exploits that position bringing together like-minded scientists from a diverse set of backgrounds to design experiments to identify promising target structures, synthesize these new targets, and study their properties and reactivity in electric fields. Broader Impacts are addressed in numerous ways. In addition to developing a new form of chemistry, the overarching broader impact is to increase the participation of underrepresented groups in STEM fields and to help educate the public about the virtues, beauty, and utility of chemistry. The work aims to transform undergraduate and graduate chemical education in chemistry at the interface of synthesis, materials and electric fields.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NSF电场化学中心（ChEF）由化学部的化学创新中心（CCI）计划支持。这个第一阶段中心由哥伦比亚大学的Latha Venkataraman领导。其他团队成员也来自哥伦比亚，包括蒂莫西·伯克巴赫、科林·纳科尔斯、托米斯拉夫·罗维斯和泽维尔·罗伊。该中心的挑战是使用定向电场来理解，控制和操纵化学过渡态，以改变化学反应的结果。新技术的发展扩大了可以通过电场控制和操纵的反应范围。将具有合成，测量和计算专业知识的团队成员聚集在一起的策略很好地实现了该中心控制和诱导新化学途径，加速催化和产生有机合成新范式的目标。该团队的大胆目标是电场控制，使传统化学催化不可能或不实用的结构，途径和中间体变得如此。通过与默克和哥伦比亚技术风险投资公司的密切合作，在一定程度上解决了更广泛的影响。学生有自我管理和专业发展的机会。学生是共同辅导和本科生包括在团队中。该团队与纽约的哈莱姆儿童区学校合作，将化学的参与范围扩大到K-12代表性不足的群体。化学魔术表演和地铁科学与工程的发展解决了非正式科学交流的期望。 第一阶段团队的纽约市位置为STEM中代表性不足的人群提供了方便。第一阶段中心的目的是利用电场来理解，控制和操纵化学反应。这些电场可以源自使用纳米级电极间隙产生的外部偏压，或者源自催化剂内的策略性放置的电荷。通过外加偏压改变过渡态，是控制物质远离平衡态并向所需反应性发展的最终证明。这项研究绘制了一条控制反应中心周围环境和电场的路径，以加速所需的反应性和选择性，开发出通过改变反应动力学和热力学而无法获得的反应途径和结果。CCI团队结合了合成，测量和计算方面的专业知识，并致力于两个跨学科的研究方向，专注于两类反应：（1）异构化和周环反应，以及（2）偶联反应。这项工作的目的是提供一个机制和定量的理解电场如何可以控制反应，同时开发路线，以改变选择性和速率在一系列的反应，包括克莱森重排，狄尔斯桤木环加成，和键活化的碳-卤素，金属-杂原子和碳-碳键。化学是纳米科学革命的中心，这项提案利用了这一立场，将来自不同背景的志同道合的科学家聚集在一起，设计实验，以确定有前途的目标结构，合成这些新目标，并研究它们在电场中的性质和反应性。更广泛的影响是通过多种方式解决的。除了开发一种新的化学形式外，更广泛的影响是增加STEM领域代表性不足的群体的参与，并帮助教育公众了解化学的美德，美丽和实用性。这项工作的目的是改变本科生和研究生化学教育在合成，材料和电场的接口。这个奖项反映了NSF的法定使命，并已被认为是值得通过评估使用基金会的智力价值和更广泛的影响审查标准的支持。

项目成果

High-Performance Organic Electronic Materials by Contorting Perylene Diimides

• DOI: 10.1021/jacs.1c11544
• 发表时间: 2021-12-23
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Schaack, Cedric;Evans, Austin M.;Nuckolls, Colin
• 通讯作者: Nuckolls, Colin

Linear Free Energy Relationships in Electrostatic Catalysis

• DOI: 10.1021/acscatal.2c02234
• 发表时间: 2022-06-27
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Hoffmann, Norah M.;Wang, Xiao;Berkelbach, Timothy C.
• 通讯作者: Berkelbach, Timothy C.