SemiSynBio-II: A Hybrid Programmable Nano-Bioelectronic System

SemiSynBio-II:混合可编程纳米生物电子系统

基本信息

  • 批准号:
    2027195
  • 负责人:
  • 金额:
    $ 150万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Living cells are equipped with highly versatile built-in toolkits of DNA, RNA, and proteins for molecular communication, computing, storage, and sensing/actuation in response to environmental stimuli. Synthetic biology has been successful in developing engineered cells by harnessing the same biological toolkits with enhanced natural functions or new human-defined functions. These engineered cells can potentially serve as a biological frontend layer that naturally interfaces with the environment and acts as biosensors/actuators, molecular computing platforms, and molecular memory to provide revolutionary solutions for many global challenges such as environmental monitoring, and healthcare. In parallel, with decades of technological advances, semiconductor technologies, e.g., Complementary-Metal-Oxide-Semiconductor (CMOS) integrated circuits (ICs), are being widely employed as a semiconductor backend layer to achieve various integration, communication, and computation capabilities. This project investigates the development of a hybrid programmable nano-bioelectronic system as a first proof-of-concept demonstration that harnesses both the exquisite synthetic functionalities of engineered bacteria as the "biological frontend" and the full functionalities of the ultra-low-power CMOS integrated circuit chips as the "semiconductor backend." The target application of such a system includes in-field biological sensor for environment monitoring. The project has potentials for long-term broader impacts on basic science, education, and technology. It brings expertise from synthetic biology, hybrid bioelectronics, integrated circuits/packaging, information theory, and computing. The project directly addresses three research themes of the solicitation: Theme-1, biomolecular memory and computation; Theme 2, interface of biology and semiconductors; Theme-4, hybrid semiconductor-biological microelectronic systems. It seeks to foster collaborations between industry and academia and hence facilitates technology transfer. The team of investigators will train graduate and undergraduate students at Georgia Tech and MIT, including minority and under-represented students. The project will also emphasize K-12 outreach to promote education of local minority high school students. In particular, the research team will recruit high school teacher interns to enhance their curricula and organize lab tours for K-12 students. The research results will be disseminated through high-impact journals, premier conferences, websites, and social media, and will be integrated into multiple related courses at Georgia Tech and MIT.The project aims to advance the science in multiple fronts and develop an integrated hybrid programmable nano-bioelectronic system. In such a system, a variety of bacteria strains are engineered as sensing, storage, and computation biological frontends to (1) perform wide-spectrum chemical sensing, e.g., heavy metal detections for environmental monitoring, (2) provide in-bacteria DNA-based storage of analog/digital information, (3) execute molecular computation via stochastic computing and encode the signal for the DNA storage, and (4) support "variable gain" reprogramming of bacteria sensors by external optical and electrical stimuli. As the integrated semiconductor electronics backend, CMOS IC chips with on-chip pixelated massively paralleled arrays will be developed to provide two-way multi-modal interfaces with the bacteria frontends, i.e., for reading stored sensory information from the bacteria and writing control signals to reprogram the bacteria sensors. The bacteria strains and CMOS ICs will be integrated together in 3D-printed microfluidics structures and packages with separate chambers. The proposed components and systems will be demonstrated through in vitro experiments using the resources at Georgia Tech and MIT.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
活细胞配备了高度通用的内置工具箱,包括DNA、RNA和蛋白质,用于分子通信、计算、存储和对环境刺激的感知/激活。合成生物学已经成功地通过利用具有增强的自然功能或新的人类定义功能的相同的生物工具包来开发工程细胞。这些工程细胞可以潜在地作为生物前端层,与环境自然对接,并作为生物传感器/执行器、分子计算平台和分子存储器,为环境监测和医疗保健等许多全球挑战提供革命性的解决方案。与此同时,随着几十年的技术进步,半导体技术,如互补金属氧化物半导体集成电路(IC),正被广泛用作半导体后端层,以实现各种集成、通信和计算能力。该项目研究了混合可编程纳米生物电子系统的开发,作为第一个概念验证演示,该系统既利用了工程细菌作为“生物前端”的精致合成功能,也利用了作为“半导体后端”的超低功耗cmos集成电路芯片的全部功能。这种系统的目标应用包括用于环境监测的现场生物传感器。该项目有可能对基础科学、教育和技术产生长期和更广泛的影响。它带来了合成生物学、混合生物电子学、集成电路/封装、信息理论和计算方面的专业知识。该项目直接涉及征集的三个研究主题:主题1,生物分子存储器和计算;主题2,生物和半导体的接口;主题4,混合半导体-生物微电子系统。它寻求促进产业界和学术界之间的合作,从而促进技术转让。调查小组将培训佐治亚理工学院和麻省理工学院的研究生和本科生,包括少数族裔和代表性不足的学生。该项目还将强调K-12外联活动,以促进当地少数民族高中生的教育。特别是,研究团队将招聘高中教师实习生,以加强他们的课程,并为K-12学生组织实验室之旅。研究成果将通过高影响力的期刊、主要会议、网站和社交媒体传播,并将被整合到佐治亚理工学院和麻省理工学院的多门相关课程中。该项目旨在推动科学在多个领域的发展,并开发一种集成的混合可编程纳米生物电子系统。在这样的系统中,各种细菌菌株被设计为传感、存储和计算生物前沿,以(1)执行广谱化学传感,例如用于环境监测的重金属检测,(2)在细菌内提供基于DNA的模拟/数字信息存储,(3)通过随机计算执行分子计算并对用于DNA存储的信号进行编码,以及(4)通过外部光和电刺激支持细菌传感器的“可变增益”重新编程。作为集成半导体电子后端,将开发具有片上像素化大规模并行阵列的CMOSIC芯片,以提供与细菌前端的双向多模式接口,即从细菌读取存储的感觉信息,并写入控制信号以对细菌传感器进行重新编程。细菌菌株和CMOSIC将被集成在3D打印的微流控结构中,并带有单独的腔室。建议的组件和系统将通过使用佐治亚理工学院和麻省理工学院的资源进行体外实验来演示。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A CMOS Multi-Modal Electrochemical and Impedance Cellular Sensing Array for Massively Paralleled Exoelectrogen Screening
LONG-TERM STABLE AND MICRO-SIZED ON-CHIP REFERENCE ELECTRODE WITH BIOCOMPATIBLE COATING
具有生物相容性涂层的长期稳定的微型片上参比电极
A General Framework for the Design of Compressive Sensing using Density Evolution
使用密度演化设计压缩感知的通用框架
A Threshold-Based Bioluminescence Detector With a CMOS-Integrated Photodiode Array in 65 nm for a Multi-Diagnostic Ingestible Capsule
  • DOI:
    10.1109/jssc.2022.3197465
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    Qijun Liu;Miguel Jimenez;Maria Eugenia Inda;Arslan Riaz;T. Zirtiloglu;A. Chandrakasan;T. Lu;
  • 通讯作者:
    Qijun Liu;Miguel Jimenez;Maria Eugenia Inda;Arslan Riaz;T. Zirtiloglu;A. Chandrakasan;T. Lu;
Engineering the human gut commensal Bacteroides thetaiotaomicron with synthetic biology
利用合成生物学改造人类肠道共生多形拟杆菌
  • DOI:
    10.1016/j.cbpa.2022.102178
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    7.8
  • 作者:
    Lai, Yong;Hayashi, Naoki;Lu, Timothy K.
  • 通讯作者:
    Lu, Timothy K.
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Faramarz Fekri其他文献

Delay analysis of two-hop network-coded delay-tolerant networks
两跳网络编码容错网络的时延分析
Analysis of Block Delivery Delay in Network Coding-based Delay Tolerant Networks
基于网络编码的延迟容忍网络中块传送延迟分析
Generalization of temporal logic tasks via future dependent options
  • DOI:
    10.1007/s10994-024-06614-y
  • 发表时间:
    2024-08-26
  • 期刊:
  • 影响因子:
    2.900
  • 作者:
    Duo Xu;Faramarz Fekri
  • 通讯作者:
    Faramarz Fekri

Faramarz Fekri的其他文献

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{{ truncateString('Faramarz Fekri', 18)}}的其他基金

FET: Small: Methods and Algorithms for microRNA Sensing: Interdependency Discovery and Inverse Problems
FET:小型:microRNA 传感的方法和算法:相互依赖性发现和逆问题
  • 批准号:
    2007807
  • 财政年份:
    2020
  • 资助金额:
    $ 150万
  • 项目类别:
    Standard Grant
MLWiNS: Collaborative Training and Inference at the Wireless Edge for Collective Intelligence
MLWiNS:无线边缘的协作训练和推理以实现集体智能
  • 批准号:
    2003002
  • 财政年份:
    2020
  • 资助金额:
    $ 150万
  • 项目类别:
    Standard Grant
Collaborative Research: Approximate Computing on Real World Data Using Representation and Coding
协作研究:使用表示和编码对现实世界数据进行近似计算
  • 批准号:
    1609823
  • 财政年份:
    2016
  • 资助金额:
    $ 150万
  • 项目类别:
    Standard Grant
III: Small: Robust and Scalable Reputation Management and Recommender Systems Using Belief Propagation
III:小型:使用信念传播的稳健且可扩展的声誉管理和推荐系统
  • 批准号:
    1115199
  • 财政年份:
    2011
  • 资助金额:
    $ 150万
  • 项目类别:
    Continuing Grant
CIF: Small: An Analytical Framework for Comprehensive Study of Intermittently-Connected Mobile Ad-Hoc Networks
CIF:小型:间歇连接移动自组织网络综合研究的分析框架
  • 批准号:
    0914630
  • 财政年份:
    2009
  • 资助金额:
    $ 150万
  • 项目类别:
    Standard Grant
Collaborative Research: Study of Wireless Ad-Hoc and Sensor Networks in a Finite Regime
协作研究:有限范围内无线自组网和传感器网络的研究
  • 批准号:
    0728772
  • 财政年份:
    2007
  • 资助金额:
    $ 150万
  • 项目类别:
    Standard Grant
Low Density Parity Check Coding: Applications and New Challenges
低密度奇偶校验编码:应用和新挑战
  • 批准号:
    0430964
  • 财政年份:
    2004
  • 资助金额:
    $ 150万
  • 项目类别:
    Continuing Grant
CAREER: Finite-Field Wavelets for Cryptography and Error Control Coding
职业:用于密码学和错误控制编码的有限场小波
  • 批准号:
    0093229
  • 财政年份:
    2001
  • 资助金额:
    $ 150万
  • 项目类别:
    Continuing Grant

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