I-Corps: Scintillating Nanoparticles for Low Energy Radioisotope Analytical Workflows

I-Corps：用于低能放射性同位素分析工作流程的闪烁纳米颗粒

• 批准号: 2028225
• 负责人: Craig Aspinwall
• 金额: $ 5万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2028225&HistoricalAwards=false
• 关键词: Corps; Scintillating; Nanoparticles; Low; Energy

The broader impact/commercial potential of this I-Corps project is the development of a new nanomaterial technology used to measure molecules that are labeled with radioisotopes at very low concentrations. This new technology will enable real-time measurement of new biochemical reactions directly in water-based solutions. In addition, this new nanomaterial technology will be broadly applicable for environmental and energy-related studies involving radioactive materials. The proposed technology addresses several limitations of existing commercial methods by reducing waste generation and disposal, enabling time-dependent measurements, enabling measurements inside of living cells, and providing simultaneous detection of multiple chemical types. This project will enable academic and industrial users to perform new biochemical and biological studies and expand the ability to measure diverse classes of important molecules, driving further innovation in multiple market spaces.This I-Corps project is based on the development of a series of nanomaterial technologies that generate light (scintillate) in the presence of radioisotopes and radioisotope-labeled compounds. The nanomaterial scintillator technology enables high-sensitivity detection of important molecules that cannot be measured using other techniques. Fine-tuning the chemical and physical properties of these nanomaterials enables them to be functional directly in aqueous environments, thereby allowing dynamic measurements of important biochemical systems. The unique nanomaterial architectures are functional in common commercial instrumentation, lowering the barrier to adoption and substantially reducing waste generation, as well as lowering back-end costs. The proposed project will explore translation of these technologies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响/商业潜力是开发一种新的纳米材料技术，用于测量用非常低浓度的放射性同位素标记的分子。 这项新技术将能够直接在水基溶液中实时测量新的生化反应。 此外，这种新的纳米材料技术将广泛适用于涉及放射性材料的环境和能源相关研究。 所提出的技术通过减少废物的产生和处置、实现时间依赖性测量、实现活细胞内的测量以及提供多种化学类型的同时检测来解决现有商业方法的几个局限性。 该项目将使学术和工业用户能够进行新的生物化学和生物学研究，并扩大测量各种重要分子的能力，推动多个市场空间的进一步创新。该I-Corps项目基于一系列纳米材料技术的开发，这些技术在放射性同位素和放射性同位素标记化合物的存在下产生光（发光）。 纳米材料闪烁体技术能够高灵敏度检测无法使用其他技术测量的重要分子。 微调这些纳米材料的化学和物理性质使它们能够直接在水环境中发挥作用，从而允许对重要的生物化学系统进行动态测量。 独特的纳米材料结构在常见的商业仪器中发挥作用，降低了采用障碍，大大减少了废物的产生，并降低了后端成本。 该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。