Core-shell nanoparticles for direct detection of radioisotopes in aqueous environments

用于直接检测水环境中放射性同位素的核壳纳米粒子

• 批准号: 1807343
• 负责人: Craig Aspinwall
• 金额: $ 36万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1807343&HistoricalAwards=false
• 关键词: Core; shell; nanoparticles; direct; detection

In this project, funded by the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Craig Aspinwall and his research group at the University of Arizona (UA) are developing new and selective sensors to probe complex systems. The measurement tools being developed offer unprecedented time resolution and selectivity for analysis of a diverse set of target molecules, potentially enabling improved understanding of biological and other complex functions. The work provides opportunities for graduate and undergraduate students from UA (a Hispanic Serving Institution) and the Arizona community college system to participate in modern, interdisciplinary chemical research, thereby helping to build a diverse science, technology, engineering and mathematics work force.The Aspinwall group is developing novel core-shell nanomaterial sensors capable of real-time detection of low-energy radioisotopes. Radioisotopes have been a cornerstone of biological research for nearly a century because of the ubiquitous nature of the most common radioisotopes of C, H, S, and P in chemical and biological systems, and because their incorporation is less invasive compared to fluorophores. Common methods of detection for radioisotopes are typically incompatible with living/functional biological systems/components and as such provide little information about system dynamics. The novel nanomaterial sensor (termed "nanoSPA") being developed by Dr. Aspinwall provides a water-soluble, biocompatible platform to enable real-time analysis of radioisotope-labeled compounds with high selectivity and sensitivity. The project focuses on development and characterization of nanoSPA sensors with emphasis on key variables that affect sensor function and performance. The work targets optimization of light output and multiplexing capabilities via integration of new scintillant materials; identification of novel biofunctionalization approaches; and performance evaluation in model biochemical systems. The project provides educational and training opportunities for undergraduate and graduate students at UA and Yavapai College to broaden exposure to interdisciplinary chemical research and enhance the nation's science workforce.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个由化学系化学测量和成像项目资助的项目中，亚利桑那大学（UA）的克雷格阿斯平沃尔教授和他的研究小组正在开发新的选择性传感器来探测复杂系统。 正在开发的测量工具为分析各种目标分子提供了前所未有的时间分辨率和选择性，可能有助于提高对生物和其他复杂功能的理解。 这项工作为来自UA（西班牙裔服务机构）和亚利桑那州社区学院系统的研究生和本科生提供了参与现代跨学科化学研究的机会，从而有助于建立一支多元化的科学，技术，工程和数学工作队伍。Aspinwall小组正在开发能够实时检测低能放射性同位素的新型核壳纳米材料传感器。 近世纪来，放射性同位素一直是生物学研究的基石，因为C、H、S和P的最常见放射性同位素在化学和生物系统中的普遍存在性质，并且因为它们的掺入与荧光团相比侵入性较小。 放射性同位素的常见检测方法通常与活的/功能性生物系统/组件不兼容，因此提供的系统动力学信息很少。 Aspinwall博士正在开发的新型纳米材料传感器（称为“nanoSPA”）提供了一种水溶性，生物相容性平台，能够以高选择性和灵敏度实时分析放射性同位素标记的化合物。 该项目的重点是nanoSPA传感器的开发和表征，重点是影响传感器功能和性能的关键变量。 该工作的目标是通过整合新的发光材料优化光输出和多路复用能力;识别新的生物功能化方法;以及在模型生化系统中进行性能评估。该项目为UA和Yavapai学院的本科生和研究生提供教育和培训机会，以拓宽跨学科化学研究的接触面，增强国家的科学劳动力。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。