Maintenance of diaphragmatic muscle force during controlled mechanical ventilation by electro-magnetic stimulation - Investigations in an ex vivo model of the rat diaphragm and in vivo.

在肺损伤的情况下，控制机械通气是关键的治疗选择，对于外科干预的目的，在麻醉期间也是如此。机械通风引起的横隔膜不活动会导致肌肉细胞的结构性耗尽(“呼吸机引起的横隔膜萎缩”)，即使在几个小时后也是如此。在患者脱离呼吸机的过程中，这种肌肉力量的丧失可能会导致严重的困难。一种维持横隔肌力量的非侵入性疗法可能适用于需要较长时间控制机械通气的患者。我们假设通过电磁刺激可以减轻横隔肌的萎缩。该项目的目的是研究如何在机械通气过程中通过中间电磁刺激来最佳地保持横隔肌的力量。因此，在体外大鼠横隔膜模型上研究了电刺激的作用。此外，我们还研究了无创电磁刺激对机械通气大鼠的影响。

Controlled mechanical ventilation is the key therapy option in case of lung injury as well as during anesthesia for the purpose of surgical interventions. The inactivity of the diaphragm caused by mechanical ventilation leads to a structural depletion of muscle cells ("ventilator induced diaphragm atrophy") even after hours. This loss in muscular strength can result in severe difficulties during weaning of the patient from the ventilator. A non-invasive therapy for maintaining diaphragmatic muscle strength could apply to patients which require controlled mechanical ventilation for longer periods. We hypothesize that by electro-magnetic stimulation the diaphragmatic muscle atrophy can be reduced. The aim of the proposed project is to investigate how diaphragmatic muscle strength can be preserved optimally by intermediate electro-magnetic stimulation during mechanical ventilation. Therefore the effects of electrical stimulation are investigated in an ex vivo model of the isolated rat diaphragm. Furthermore the effects of non-invasive electro-magnetic stimulation are investigated in mechanically ventilated rats.