Maintenance of diaphragmatic muscle force during controlled mechanical ventilation by electro-magnetic stimulation - Investigations in an ex vivo model of the rat diaphragm and in vivo.

通过电磁刺激控制机械通气期间膈肌力量的维持 - 大鼠膈肌离体模型和体内的研究。

• 批准号: 243567390
• 负责人: Professor Dr. Stefan Schumann
• 金额: --
• 依托单位: Klinik für Anästhesiologie und Intensivmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/243567390?language=en
• 关键词: Maintenance; diaphragmatic; muscle; force; during

Controlled mechanical ventilation is the key therapy option in case of lung injury as well as during anesthesia for the purpose of surgical interventions. The inactivity of the diaphragm caused by mechanical ventilation leads to a structural depletion of muscle cells ("ventilator induced diaphragm atrophy") even after hours. This loss in muscular strength can result in severe difficulties during weaning of the patient from the ventilator. A non-invasive therapy for maintaining diaphragmatic muscle strength could apply to patients which require controlled mechanical ventilation for longer periods. We hypothesize that by electro-magnetic stimulation the diaphragmatic muscle atrophy can be reduced. The aim of the proposed project is to investigate how diaphragmatic muscle strength can be preserved optimally by intermediate electro-magnetic stimulation during mechanical ventilation. Therefore the effects of electrical stimulation are investigated in an ex vivo model of the isolated rat diaphragm. Furthermore the effects of non-invasive electro-magnetic stimulation are investigated in mechanically ventilated rats.

受控机械通气是肺损伤情况下以及出于手术干预目的的麻醉期间的关键治疗选择。由机械通气引起的横膈膜的不活动甚至在数小时后导致肌细胞的结构性消耗（“通气机诱导的横膈膜萎缩”）。这种肌肉力量的损失可能导致患者在脱离呼吸机期间出现严重困难。一种用于维持上肢肌肉力量的非侵入性疗法可以适用于需要较长时间受控机械通气的患者。我们推测，通过电磁刺激，可以减少延髓肌肉萎缩。该项目的目的是研究如何在机械通气过程中通过中间电磁刺激来最佳地保持肌肉力量。因此，在离体大鼠膈肌模型中研究电刺激的效果。此外，在机械通气大鼠中研究了非侵入性电磁刺激的效果。

项目成果

Mechanical ventilation restores blood gas homeostasis and diaphragm muscle strength in ketamine/medetomidine‐anaesthetized rats

机械通气可恢复氯胺酮/美托咪定麻醉大鼠的血气稳态和膈肌强度

• DOI: 10.1113/ep089141
• 发表时间: 2021
• 期刊: Experimental Physiology
• 影响因子: 2.7
• 作者: Wenzel C;Schmidt J;Urban G;Schumann S;Spassov SG
• 通讯作者: Spassov SG

Electromagnetic stimulation of the phrenic nerve preserves diaphragm muscle strength during mechanical ventilation in a rat model.

膈神经电磁刺激可在大鼠模型机械通气期间保持膈肌强度

• DOI: 10.1097/eja.0000000000001590
• 发表时间: 2021
• 期刊: European journal of anaesthesiology
• 影响因子: 3.6
• 作者: Wenzel C;Spassov SG;Lengerer J;Schmidt J;Urban G;Schumann S
• 通讯作者: Schumann S

Loss of muscular force in isolated rat diaphragms is related to changes in muscle fibre size

离体大鼠膈肌肌力的丧失与肌纤维尺寸的变化有关

• DOI: 10.1088/1361-6579/abdf3a
• 发表时间: 2021
• 期刊: Physiological Measurement
• 影响因子: 3.2
• 作者: Lieb S;Schumann S
• 通讯作者: Schumann S