Influence of inspiratory and expiratory ventilation patterns on ventilatory associated lung injury

控制性机械通气是重症监护医学中维持生命的关键治疗。然而，呼吸机相关的肺损伤仍然是一个未解决的问题。在受控机械通气的条件下，吸气的时间曲线由通气机限定，并且被动发生的呼气曲线由（患病的）呼吸系统限定。在通气模式方面，机械通气期间的肺机械刺激与自主呼吸期间的肺机械刺激有根本不同。尚未系统地分析通气模式的时间分量的影响，特别是关于呼气的进展。所提交项目的假设是，肺组织损伤显著依赖于呼吸曲线的时间分量，特别是在呼气的时间过程方面。出于这个原因，我们建议研究在何种程度上，呼吸机相关的肺损伤可以减少机械刺激配置文件的修改，在实验性肺损伤模型的通气大鼠。

Controlled mechanical ventilation is the life-sustaining key therapy in intensive care medicine. Nevertheless, ventilator associated lung injury remains an unsolved problem. Under the conditions of controlled mechanical ventilation the temporal profile for the inspiration is defined by the ventilator and the passively occurring expiration profile is defined by the (diseased) respiratory system. With respect to ventilation pattern, the pulmonary mechanostimulation during mechanical ventilation differs fundamentally from that during spontaneous breathing. The influence of temporal components of the ventilation pattern, particularly with regard to the progress of the expiration, has not yet been analyzed systematically. The hypothesis of the submitted project is that lung tissue damage is significantly dependent on the temporal components of the ventilatory profile, especially in terms of the time course of the expiration. For that reason we propose to study the extent to which ventilator associated lung injury can be reduced by the modification of the mechanical stimulation profile in experimental lung injury models of ventilated rats.