Influence of inspiratory and expiratory ventilation patterns on ventilatory associated lung injury

控制机械通气是重症监护医学维持生命的关键手段。然而，呼吸机相关的肺损伤仍然是一个未解决的问题。在受控机械通气条件下，吸气的时间分布由呼吸机决定，而被动发生的呼气分布由（患病的）呼吸系统决定。在通气方式方面，机械通气时的肺机械刺激与自然呼吸时的肺机械刺激有本质区别。通气模式的时间组成部分的影响，特别是关于呼气的进展，还没有被系统地分析。所提交项目的假设是，肺组织损伤在很大程度上取决于通气剖面的时间成分，特别是在呼气的时间过程中。因此，我们建议研究通过改变通气大鼠实验性肺损伤模型的机械刺激谱来减少呼吸机相关肺损伤的程度。

Controlled mechanical ventilation is the life-sustaining key therapy in intensive care medicine. Nevertheless, ventilator associated lung injury remains an unsolved problem. Under the conditions of controlled mechanical ventilation the temporal profile for the inspiration is defined by the ventilator and the passively occurring expiration profile is defined by the (diseased) respiratory system. With respect to ventilation pattern, the pulmonary mechanostimulation during mechanical ventilation differs fundamentally from that during spontaneous breathing. The influence of temporal components of the ventilation pattern, particularly with regard to the progress of the expiration, has not yet been analyzed systematically. The hypothesis of the submitted project is that lung tissue damage is significantly dependent on the temporal components of the ventilatory profile, especially in terms of the time course of the expiration. For that reason we propose to study the extent to which ventilator associated lung injury can be reduced by the modification of the mechanical stimulation profile in experimental lung injury models of ventilated rats.