RAPID: Regenerable Antiviral Nanoporous Materials for Protection

RAPID：用于保护的可再生抗病毒纳米多孔材料

• 批准号: 2029270
• 负责人: Omar Farha
• 金额: $ 20万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2029270&HistoricalAwards=false
• 关键词: RAPID; Regenerable; Antiviral; Nanoporous; Materials

Non-Technical AbstractWith over 2 million positive cases and 160 thousand deaths as of mid-April 2020, global society is currently suffering physically, socially, economically, and politically because of the ongoing pandemic outbreak - Coronavirus Disease 2019 (COVID-19). The main pathway that the virus is spreading is through respiratory droplets produced when people sneeze or cough, which can then infect people nearby. Thus, the United Statesʹ Centers for Disease Control and Prevention (CDC) has recommended covering one’s face to help slow down the spread of the virus. The traditional face masks, however, can only act as a physical barrier, which means that the virus will stay active on the mask and can still be transmitted if touched while removing/wearing the mask. Therefore, developing face masks to deactivate the viral threats can efficiently stop/slow the spread of the highly infectious virus, COVID-19. With funding from the Solid State and Materials Chemistry Program in the Division of Materials Research of the Mathematical and Physical Sciences Directorate, this Rapid Response Research (RAPID) grant supports research that focuses on developing antiviral masks by chemically modifying the textile surfaces to deactivate the viral threats; this in turn reduces the risk of spreading the virus and generates reusable masks. The research serves the national interest and NSFʹs mission by developing advanced technologies from hypothesis-driven scientific research to protect our nation’s physical, social, economic, and political health and welfare.Technical AbstractThis Rapid Response Research (RAPID) grant supports research that employs nanoporous materials to modify textile fibers and generate antiviral facial masks with funding from the Solid State and Materials Chemistry Program in the Division of Materials Research of the Mathematical and Physical Sciences Directorate. The support enables a materials science approach that mitigates the negative impacts of COVID-19 on public health. Masks that not only protect the wearer but also deactivate the virus significantly reduce the spread of infectious viral threats such as COVID-19 since an active virus residing on a mask still possesses a great threat to the wearer and their environment. This research project investigates means to cover the surfaces of textile fibers with antiviral agents that are active towards viral threats; in this way, the viruses can be deactivated by disintegration upon contact and/or post-treatment while filtered air is allowed to pass through the mask safely. Specifically, the researchers employ the integration of metal–organic framework based antiviral composites on textiles-based facial masks and later on N95 or similar masks. The protective nano layer added on the masks enables the disintegration of the viral threats, which allows the reuse of masks due to reduction of cross contamination during removal and/or wearing of the masks. This RAPID project offers a solution to the severely urgent challenge of the shortage of effective antiviral protective materials while advancing physical and materials science and educating the general public on the research-driven solutions to global challenges.This grant is being awarded using funds made available by the Coronavirus Aid, Relief, and Economic Security (CARES) Act supplemental funds allocated to MPS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要截至2020年4月中旬，全球有200多万阳性病例和16万人死亡，由于持续爆发的大流行--冠状病毒病2019(新冠肺炎)，全球社会目前正在遭受身体、社会、经济和政治方面的痛苦。病毒传播的主要途径是通过人们打喷嚏或咳嗽时产生的呼吸道飞沫，然后感染附近的人。因此，美国疾病控制和预防中心(ʹ)建议遮盖面部以帮助减缓病毒的传播。然而，传统口罩只能起到物理屏障的作用，这意味着病毒将保持在口罩上的活动状态，如果在摘下/戴口罩时触摸，病毒仍然可以传播。因此，开发口罩来解除病毒威胁，可以有效地阻止/减缓高传染性病毒新冠肺炎的传播。在数学和物理科学局材料研究部固态和材料化学计划的资助下，这项快速反应研究(RAPID)赠款支持专注于通过对纺织品表面进行化学修饰以消除病毒威胁来开发抗病毒口罩的研究；这反过来又降低了病毒传播的风险，并产生了可重复使用的口罩。这项研究服务于国家利益和国家科学基金会ʹS的使命，通过开发假设驱动的科学研究的先进技术来保护我们国家的身体、社会、经济和政治健康和福利。技术摘要这项快速反应研究(RAPID)拨款支持使用纳米多孔材料来改性纺织纤维和生产抗病毒面膜的研究，资金来自数学和物理科学局材料研究部的固体和材料化学计划。这一支持使得材料科学的方法能够减轻新冠肺炎对公共健康的负面影响。口罩不仅可以保护佩戴者，还可以使病毒失活，从而显著减少新冠肺炎等传染性病毒威胁的传播，因为口罩上存在的活跃病毒仍然对佩戴者和他们的环境构成巨大威胁。这项研究项目研究了在纺织纤维表面覆盖对病毒威胁有效的抗病毒剂的方法；通过这种方式，病毒可以在接触和/或后处理时通过分解来灭活，同时允许过滤的空气安全地通过口罩。具体地说，研究人员将基于金属-有机骨架的抗病毒复合材料集成到基于纺织品的面膜上，然后应用到N95或类似的口罩上。添加在口罩上的保护纳米层能够分解病毒威胁，这允许由于在移除和/或佩戴口罩期间减少交叉污染而重复使用口罩。这一快速项目为有效的抗病毒防护材料短缺这一严重紧迫的挑战提供了解决方案，同时促进了物理和材料科学，并教育公众了解以研究为导向的解决方案，以应对全球挑战。这笔赠款是使用冠状病毒援助、救济和经济安全(CARE)法案提供的资金发放的，分配给MP的补充资金。这一奖励反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Chemically Engineered Porous Molecular Coatings as Reactive Oxygen Species Generators and Reservoirs for Long‐Lasting Self‐Cleaning Textiles

化学工程多孔分子涂层作为活性氧发生器和储库，用于持久的自清洁纺织品

• DOI: 10.1002/anie.202115956
• 发表时间: 2022
• 期刊: Angewandte Chemie International Edition
• 作者: Wang, Yao;Ma, Kaikai;Bai, Jiaquan;Xu, Tao;Han, Wendong;Wang, Chen;Chen, Zhenxia;Kirlikovali, Kent O.;Li, Peng;Xiao, Jisheng
• 通讯作者: Xiao, Jisheng

Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection

• DOI: 10.1002/anie.202202207
• 发表时间: 2022-03-11
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Ha Cheung, Yuk;Ma, Kaikai;Farha, Omar K.
• 通讯作者: Farha, Omar K.

Immobilized Regenerable Active Chlorine within a Zirconium-Based MOF Textile Composite to Eliminate Biological and Chemical Threats

• DOI: 10.1021/jacs.1c08576
• 发表时间: 2021-09-30
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Cheung, Yuk Ha;Ma, Kaikai;Farha, Omar K.
• 通讯作者: Farha, Omar K.