SBIR Phase I: Regenerable Antimicrobial Paints Based on Hydrogen Peroxide

该小企业创新研究 (SBIR) 第一阶段项目的更广泛影响将是减少和防止病原体的表面传播，从而帮助公共和机构空间变得更清洁、更安全，特别是对于高危人群而言。可以通过杀死细菌、霉菌和真菌来预防医院获得性感染；并在病毒传播给另一个人之前灭活表面上的病毒。该项目将开发基于过氧化氢（HP）的抗菌涂料，这种涂料不会产生有毒的降解产物，因为它会转化为水和氧气。 HP 具有悠久的安全使用历史，不会产生传染性生物体的耐药菌株。 这些涂料可以改善卫生状况，并可以使用基于过氧化物的试剂进行更有效的清洁，从而使涂料能够重新发挥其抗菌功效，从而提供持久的保护，而无需使用剧毒化学物质。竞争性抗菌涂料价格昂贵，未表现出长期抗菌活性，或者使用了存在产生微生物耐药性风险的化学物质。所提出的基于过氧化物的抗菌涂料将更便宜，并且实施起来非常安全，可以在清洁过程中恢复功效。这将使它能够在公共卫生和机构环境中得到更广泛的使用，以帮助预防传染性感染。拟议的项目解决了开发可再生抗菌涂料的技术挑战，其基础是在配方中使用 HP，以实现具有长期功效的广谱抗菌和杀病毒活性。该项目利用新技术生产油漆涂层，可以将 HP 以干燥的非挥发性形式隔离到涂层表面中。这使得HP随着时间的推移缓慢释放，可以通过暴露于含有HP的市售溶液来再生。惠普会退化为无害产品。细菌和病毒无法对其消毒机制产生耐药性。因此，所得产品及其再生过程将是持久的、具有成本效益的且对环境安全的。该项目要解决的技术挑战包括确保涂料的配方稳定性、抗菌和杀病毒效力和充电功能，以及 HP 对涂料完整性的影响。该团队将与特种涂料专家密切合作，开发和测试可行的涂料配方。预期的技术成果包括技术的原型版本、研究成果的文档和进一步的再生要求。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project will be to reduce and prevent surface-based transmission of pathogens and thereby help public and institutional spaces become cleaner and safer, especially for at-risk populations. Hospital-acquired infections can be prevented by killing bacteria, molds, and fungi; and inactivating viruses on surfaces before they are able to pass to another person. The project will develop antimicrobial paints based on hydrogen peroxide (HP), which does not have toxic degradation products since it turns into water and oxygen. HP has a long history of safe use, without allowing generation of resistant strains of infectious organisms. The paints can improve hygiene, and allow more efficient cleaning with peroxide-based agents, from which the paints can regenerate their antimicrobial efficacy, providing durable protection without highly toxic chemical applications. Competing antimicrobial paints are expensive, have not demonstrated long-term antimicrobial activity, or have used chemistries that carry the risk of developing microbial resistance. The proposed peroxide based antimicrobial paint will be more affordable, and very safe to implement, allowing regeneration of efficacy during cleaning. This will enable more widespread use in public health and institutional settings to help protect against transmissible infections.The proposed project addresses the technical challenge of developing an antimicrobial paint that can be regenerated, based on the use of HP in the formulation to achieve broad-spectrum antimicrobial and virucidal activity with long-term efficacy. This project leverages new technology to produce paint coatings that can sequester HP into a coated surface in a dry non-volatile form. This enables the slow release of HP over time that can be regenerated by exposure to commercially available solutions containing HP. HP degrades into innocuous products. Bacteria and viruses are not able to develop resistance to its disinfecting mechanism. Hence, the resulting product and its regeneration process will be long-lasting, cost-effective and environmentally safe. Technical challenges to be addressed in this project include ensuring formulation stability, antimicrobial and virucidal potency and recharging functionality of the paint, and the effects of HP on paint integrity. The team will closely collaborate with specialty coatings experts to develop and test viable paint formulations. Anticipated technical results include a prototype version of the technology, and documentation of the research outcomes and further regeneration requirements.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.