SBIR Phase I: Regenerable Antimicrobial Paints Based on Hydrogen Peroxide

小企业创新研究（SBIR）第一阶段项目的更广泛影响将是减少和预防病原体的表面传播，从而帮助公共和机构空间变得更清洁，更安全，特别是对高危人群。医院获得性感染可以通过杀死细菌，霉菌和真菌来预防;并在病毒能够传递给另一个人之前灭活表面上的病毒。该项目将开发基于过氧化氢（HP）的抗菌涂料，这种涂料不会产生有毒的降解产物，因为它会变成水和氧气。HP具有长期的安全使用历史，不会产生感染性微生物的耐药菌株。 该涂料可以改善卫生，并允许使用基于过氧化物的试剂进行更有效的清洁，涂料可以从中再生其抗菌功效，提供持久的保护，而无需使用剧毒化学品。竞争的抗菌涂料价格昂贵，没有表现出长期的抗菌活性，或者使用的化学物质有产生微生物抗性的风险。所提出的基于过氧化物的抗微生物涂料将更经济实惠，并且实施起来非常安全，允许在清洁期间再生功效。这将有助于在公共卫生和机构环境中更广泛地使用，以帮助预防传染性感染。拟议项目解决了开发一种可再生的抗菌涂料的技术挑战，该涂料基于在配方中使用HP，以实现广谱抗菌和杀病毒活性，并具有长期功效。该项目利用新技术生产油漆涂料，可以将HP以干燥非挥发性形式隔离到涂层表面。这使得HP能够随时间缓慢释放，其可以通过暴露于含有HP的市售溶液而再生。惠普会退化成无害的产品。细菌和病毒不能对其消毒机制产生抵抗力。因此，所得产品及其再生过程将是持久的，具有成本效益和环境安全的。该项目中要解决的技术挑战包括确保配方稳定性、抗菌和杀病毒效力以及涂料的再充电功能，以及HP对涂料完整性的影响。该团队将与特种涂料专家密切合作，开发和测试可行的涂料配方。预期的技术成果包括该技术的原型版本，以及研究成果和进一步再生要求的文件。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project will be to reduce and prevent surface-based transmission of pathogens and thereby help public and institutional spaces become cleaner and safer, especially for at-risk populations. Hospital-acquired infections can be prevented by killing bacteria, molds, and fungi; and inactivating viruses on surfaces before they are able to pass to another person. The project will develop antimicrobial paints based on hydrogen peroxide (HP), which does not have toxic degradation products since it turns into water and oxygen. HP has a long history of safe use, without allowing generation of resistant strains of infectious organisms. The paints can improve hygiene, and allow more efficient cleaning with peroxide-based agents, from which the paints can regenerate their antimicrobial efficacy, providing durable protection without highly toxic chemical applications. Competing antimicrobial paints are expensive, have not demonstrated long-term antimicrobial activity, or have used chemistries that carry the risk of developing microbial resistance. The proposed peroxide based antimicrobial paint will be more affordable, and very safe to implement, allowing regeneration of efficacy during cleaning. This will enable more widespread use in public health and institutional settings to help protect against transmissible infections.The proposed project addresses the technical challenge of developing an antimicrobial paint that can be regenerated, based on the use of HP in the formulation to achieve broad-spectrum antimicrobial and virucidal activity with long-term efficacy. This project leverages new technology to produce paint coatings that can sequester HP into a coated surface in a dry non-volatile form. This enables the slow release of HP over time that can be regenerated by exposure to commercially available solutions containing HP. HP degrades into innocuous products. Bacteria and viruses are not able to develop resistance to its disinfecting mechanism. Hence, the resulting product and its regeneration process will be long-lasting, cost-effective and environmentally safe. Technical challenges to be addressed in this project include ensuring formulation stability, antimicrobial and virucidal potency and recharging functionality of the paint, and the effects of HP on paint integrity. The team will closely collaborate with specialty coatings experts to develop and test viable paint formulations. Anticipated technical results include a prototype version of the technology, and documentation of the research outcomes and further regeneration requirements.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.