SBIR Phase I: Regenerable Antimicrobial Paints Based on Hydrogen Peroxide

这项小企业创新研究（SBIR）第一阶段项目的更广泛影响将是减少和预防病原体的表面传播，从而帮助公共和机构空间变得更清洁和更安全，特别是对高危人群。医院获得性感染可以通过杀死细菌、霉菌和真菌来预防；在病毒传播给另一个人之前灭活表面上的病毒。该项目将开发以过氧化氢（HP）为基础的抗菌涂料。过氧化氢可以转化为水和氧气，没有有毒的降解产物。HP具有安全使用的悠久历史，不允许产生耐药的感染性生物菌株。这种涂料可以改善卫生，并允许更有效地使用过氧化氢清洗剂进行清洁，涂料可以再生其抗菌功效，提供持久的保护，而无需使用剧毒化学品。与之竞争的抗菌涂料价格昂贵，没有长期的抗菌活性，或者使用了可能产生微生物耐药性的化学物质。提议的过氧化氢抗菌涂料将更经济实惠，并且非常安全，可以在清洁过程中再生功效。这将有助于在公共卫生和机构环境中更广泛地使用，以帮助防止传播感染。拟议的项目解决了开发一种可再生的抗菌涂料的技术挑战，该涂料基于配方中HP的使用，以实现广谱抗菌和长期有效的病毒活性。该项目利用新技术生产涂料，可以将HP以干燥的非挥发形式隔离到涂层表面。这使得随着时间的推移，HP可以缓慢释放，可以通过暴露于含有HP的市售解决方案来再生。HP分解成无害的产品。细菌和病毒不能对其消毒机制产生抗药性。因此，所产生的产品及其再生过程将是持久的，具有成本效益和环境安全。该项目需要解决的技术挑战包括确保涂料的配方稳定性、抗菌和抗病毒效力以及充电功能，以及HP对涂料完整性的影响。该团队将与特种涂料专家密切合作，开发和测试可行的涂料配方。预期的技术成果包括该技术的原型版本，以及研究成果和进一步再生需求的文档。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project will be to reduce and prevent surface-based transmission of pathogens and thereby help public and institutional spaces become cleaner and safer, especially for at-risk populations. Hospital-acquired infections can be prevented by killing bacteria, molds, and fungi; and inactivating viruses on surfaces before they are able to pass to another person. The project will develop antimicrobial paints based on hydrogen peroxide (HP), which does not have toxic degradation products since it turns into water and oxygen. HP has a long history of safe use, without allowing generation of resistant strains of infectious organisms. The paints can improve hygiene, and allow more efficient cleaning with peroxide-based agents, from which the paints can regenerate their antimicrobial efficacy, providing durable protection without highly toxic chemical applications. Competing antimicrobial paints are expensive, have not demonstrated long-term antimicrobial activity, or have used chemistries that carry the risk of developing microbial resistance. The proposed peroxide based antimicrobial paint will be more affordable, and very safe to implement, allowing regeneration of efficacy during cleaning. This will enable more widespread use in public health and institutional settings to help protect against transmissible infections.The proposed project addresses the technical challenge of developing an antimicrobial paint that can be regenerated, based on the use of HP in the formulation to achieve broad-spectrum antimicrobial and virucidal activity with long-term efficacy. This project leverages new technology to produce paint coatings that can sequester HP into a coated surface in a dry non-volatile form. This enables the slow release of HP over time that can be regenerated by exposure to commercially available solutions containing HP. HP degrades into innocuous products. Bacteria and viruses are not able to develop resistance to its disinfecting mechanism. Hence, the resulting product and its regeneration process will be long-lasting, cost-effective and environmentally safe. Technical challenges to be addressed in this project include ensuring formulation stability, antimicrobial and virucidal potency and recharging functionality of the paint, and the effects of HP on paint integrity. The team will closely collaborate with specialty coatings experts to develop and test viable paint formulations. Anticipated technical results include a prototype version of the technology, and documentation of the research outcomes and further regeneration requirements.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.