EAGER-Development of Antiviral Functionalized Carbon Nanotubes (CNTs) for Generating Virus-free Medical Grade Water and Preventing the Spread of COVID-19

EAGER-开发抗病毒功能化碳纳米管 (CNT)，用于生成无病毒医用级水并防止 COVID-19 传播

• 批准号: 2030282
• 负责人: Somenath Mitra
• 金额: $ 13.86万
• 依托单位: New Jersey Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2030282&HistoricalAwards=false
• 关键词: EAGER; Development; Antiviral; Functionalized; Carbon

At this point there is an urgent need to address many issues related to the Corona virus (COVID-19) outbreak including stopping the spread of the virus, and helping the overwhelmed healthcare industry cope with different problems. The goal of this project is to generate antiviral functionalized carbon nanotubes which will have several applications related to the COVID-19 pandemic. First, the functionalized nanotubes can be used as self-cleaning sorbents in personal protection equipment (PPE) such as medical masks. Many commercial paints/coatings formulations contain carbon nanotubes, and the anti-viral nanotubes will be effective materials for preventing the spread of COVID-19 via surface contacts. An immediate application is carbon nanotube-enhanced membrane distillation for inexpensive bacteria/endotoxin/virus-free medical-grade water generation. This water is used for cleaning medical equipment and as injectable water in patient treatment. Most importantly the membrane distillation with antiviral nanotubes will be developed into a point-of-care technology where a domestic water heater or a microwave oven can be used to generate medical grade water in field hospitals. The Objective of this project is to develop functionalized carbon nanotubes with high anti-viral activity for stopping the spread of Covid-19 and helping the overwhelmed healthcare industry. The work will be an extension of work already underway with bacteria and endotoxins. The two major proposed tasks are the development of specific carbon nanotube functional forms with antiviral activity, and the development of carbon nanotube enhanced microwave induced membrane distillation for generating bacteria/endotoxins/virus free medical grade water. In the first task, functionalized carbon nanotubes will be synthesized by the incorporation of different antiviral agents. In the second task these nanotubes will be used to synthesize biocidal membranes for membrane distillation. In the proposed process, as the hot contaminated water will pass over the antiviral nanotube membrane, it will be partially transformed to water vapor that will pass through as purified water while the hydrophobic membrane will prevent the aqueous phase from permeating through. In this project we also propose to use microwaves to heat the water because this has additional biocidal effects. The novel membranes developed by immobilizing the antiviral carbon nanotubes will not only serve as molecular transporters for pure water generation, but also have biocidal properties that will generate highly pure medical grade water. The developed approach will open the door to specific carbon nanotube functionalization to deal with different bacteria and virus. These functionalized nanotubes can be used in adsorbents and membranes to provide effective virus protection in air purifiers, in personal protection equipment (PPE) such as gas masks and for water treatment. Since many commercial paints/coatings formulations contain carbon nanotubes, the anti-viral nanotubes in surface coating will serve to prevent the spread of COVID-19 (or other viruses) that transmit via surface contacts. The educational goal of the project is the expansion of nanotechnology into disease prevention and medical infrastructure, which has not been emphasized in the past but has significant potential benefits.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这一点上，迫切需要解决与冠状病毒（COVID-19）爆发有关的许多问题，包括阻止病毒的传播，并帮助不堪重负的医疗保健行业科普不同的问题。该项目的目标是产生抗病毒功能化碳纳米管，其将具有与COVID-19大流行相关的多个应用。首先，官能化的纳米管可用作个人防护设备（PPE）如医用口罩中的自清洁吸附剂。许多商业油漆/涂料配方含有碳纳米管，抗病毒纳米管将是防止COVID-19通过表面接触传播的有效材料。一个直接的应用是碳纳米管增强膜蒸馏，用于廉价的无细菌/内毒素/病毒的医疗级水的产生。这些水用于清洁医疗设备和作为患者治疗中的注射用水。 最重要的是，具有抗病毒纳米管的膜蒸馏将被开发成一种即时技术，在这种技术中，家用热水器或微波炉可用于在野战医院生产医疗级水。该项目的目的是开发具有高抗病毒活性的功能化碳纳米管，以阻止Covid-19的传播，并帮助不堪重负的医疗保健行业。这项工作将是已经在细菌和内毒素方面进行的工作的延伸。提出的两个主要任务是开发具有抗病毒活性的特定碳纳米管功能形式，以及开发碳纳米管增强的微波诱导膜蒸馏以产生无细菌/内毒素/病毒的医疗级水。在第一个任务中，功能化的碳纳米管将通过掺入不同的抗病毒剂来合成。在第二个任务中，这些纳米管将用于合成用于膜蒸馏的生物杀灭膜。在所提出的方法中，当热的污染水将通过抗病毒纳米管膜时，它将部分转化为水蒸气，水蒸气将作为净化水通过，而疏水膜将防止水相渗透通过。在这个项目中，我们还建议使用微波来加热水，因为这具有额外的杀菌效果。通过固定抗病毒碳纳米管开发的新型膜不仅可以作为纯水生成的分子转运体，而且还具有生物杀灭特性，可以生成高纯度的医疗级水。开发的方法将为特定的碳纳米管功能化打开大门，以处理不同的细菌和病毒。这些功能化的纳米管可用于吸附剂和膜中，以在空气净化器、个人防护设备（PPE）（如防毒面具）和水处理中提供有效的病毒保护。由于许多商业油漆/涂料配方含有碳纳米管，表面涂层中的抗病毒纳米管将用于防止通过表面接触传播的COVID-19（或其他病毒）的传播。该项目的教育目标是将纳米技术扩展到疾病预防和医疗基础设施中，这在过去没有得到强调，但具有显著的潜在效益。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。