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I-Corps: Rapid field detection of crop pathogens using portable reflective interferometry

I-Corps：使用便携式反射干涉仪快速现场检测作物病原体

基本信息

批准号：
2034784
负责人：
Lewis Rothberg
金额：
$ 5万
依托单位：
University of Rochester
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2021-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2034784&HistoricalAwards=false
关键词：
Corps Rapid field detection crop

项目摘要

The broader impact/commercial potential of this I-Corps project is the development of a portable detector for pathogen testing of fruit crops in the field. The market for agricultural testing is over $20 billion per year, with greater potential for smaller firms for whom the current methods are impractical. Getting immediate results in the field is important since disease can spread through orchards in days and ruin entire crops. The proposed architecture may be applicable to point-of-care diagnostic sensors for food safety applications and for animal and human disease detection. This I-Corps project is based on the development of an optical platform that is designed to produce large changes in reflectivity when small amounts of material adhere to its surface. The system uses a robust and convenient substrate, silicon, and a simple light-emitting diode, to implement the platform. Attached antibodies selectively bind specific pathogens of interest to the substrate in a way enabling the antibodies to recognize the appropriate target antigen even when immobilized on the surface. Sensitive detection is achieved through a process that discourages unwanted molecules from sticking to the surface.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目更广泛的影响/商业潜力是开发一种便携式检测器，用于田间水果作物病原体检测。农业测试市场每年超过200亿美元，对于目前的方法不切实际的小公司来说，潜力更大。在田间取得立竿见影的效果是很重要的，因为疾病可以在几天内通过果园传播，并摧毁整个作物。所提出的架构可以适用于用于食品安全应用以及用于动物和人类疾病检测的即时诊断传感器。这个I-Corps项目是基于一个光学平台的开发，该平台旨在当少量材料粘附在其表面时产生反射率的巨大变化。该系统使用一个强大的和方便的基板，硅，和一个简单的发光二极管，实现平台。附着的抗体选择性地将感兴趣的特定病原体结合到基底上，使得抗体即使在固定在表面上时也能够识别适当的靶抗原。通过阻止不需要的分子粘附在表面的过程实现灵敏的检测。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。