SBIR Phase I: Slowing the Spread of COVID-19: Development of Persistent Antimicrobial Compositions to Prevent Cross-Contamination via Hands and Gloves

SBIR 第一阶段：减缓 COVID-19 的传播：开发持久性抗菌组合物以防止通过手和手套交叉污染

• 批准号: 2036017
• 负责人: Zachary Bendiks
• 金额: $ 25.6万
• 依托单位: CARRISAN TECHNOLOGIES INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036017&HistoricalAwards=false
• 关键词: SBIR; Phase; Slowing; Spread; COVID

The broader impact/commercial potential of this Small Business Innovation Research SBIR project will be to transform the ability to control cross-contamination by pathogens via hands and gloves in the healthcare and food sectors and strengthen the nation’s response to the COVID-19 crisis by limiting its spread. This innovation will also reduce the healthcare-acquired infections from other pathogens that cause 1.7 million illnesses, 98,000 deaths and an estimated $45 billion annually in direct costs to US hospitals. Cross-contamination via hands and gloves is a leading cause of spread of pathogens and resulting infections. Handwashing and hand sanitizers provide periodic sanitation, however, cross-contamination via hands between periodic handwashing or sanitizing is an inherent risk. Likewise, donning fresh gloves helps ensure the gloves used are sanitary, but they become contaminated during use. Innovations described in this proposal provide continuous sanitation for hands between handwashing and between changes of gloves. Maintaining persistent antimicrobial activity for an extended period on hands and gloves of workers will reduce transmission of pathogens including SARS CoV-2. This research aims to develop cell-based antimicrobial compositions with diverse class of antimicrobials to coat both biotic surfaces (hands) and abiotic surfaces (gloves) for persistent antimicrobial activity.This SBIR Phase I project proposes to address the technical challenges in maintaining persistent antimicrobial activity on both biotic and abiotic surfaces against viral and bacterial targets including SARS CoV-2. The technical challenges include: (a) ability of antimicrobial compositions to persist on biotic and abiotic surfaces in the presence of organic content including proteins, lipids and cells as well as physical factors including sweat and mechanical forces; (b) achieving rapid inactivation of contaminating pathogens on complex surfaces such as hands and gloves; and (c) ensuring the biocompatibility of the compositions and removal with simple washing steps. To address these challenges this proposed research aims to develop innovations in the following technical areas: (a) discovery of cellular compositions and process engineering to stabilize diverse antimicrobials and maintain rapid inactivation of pathogens (b) development of nature inspired designs for retaining cell-based antimicrobial compositions on skin surfaces to maintain persistent antimicrobial activity (c) engineering polymer compositions to retain cell-based compositions on abiotic surfaces and (d) engineer cellular compositions to achieve rapid inactivation of these pathogens. This may be achieved based on engineering affinity of the carrier compositions for pathogens as well as the release rate of antimicrobials from cell-based carriers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业创新研究SBIR项目的更广泛影响/商业潜力将是改变医疗保健和食品行业通过手和手套控制病原体交叉污染的能力，并通过限制其传播来加强国家对COVID-19危机的应对。这项创新还将减少其他病原体的医疗获得性感染，这些病原体导致170万人患病，98，000人死亡，估计每年给美国医院造成450亿美元的直接成本。通过手和手套的交叉污染是病原体传播和导致感染的主要原因。洗手和洗手液提供定期的卫生，但是，在定期洗手或消毒之间通过手的交叉污染是一种固有的风险。同样，戴上新手套有助于确保所使用的手套卫生，但它们在使用过程中会被污染。本提案中描述的创新为洗手和更换手套之间的手部提供了持续的卫生。在工人的手和手套上长时间保持持久的抗菌活性将减少包括SARS CoV-2在内的病原体的传播。本研究的目的是开发基于细胞的抗菌组合物与不同类别的抗菌剂涂层的生物表面（手）和非生物表面（手套）持久的抗菌活性。SBIR第一阶段项目提出了解决的技术挑战，保持持久的抗菌活性的生物和非生物表面对病毒和细菌的目标，包括SARS CoV-2。技术挑战包括：（a）在包括蛋白质、脂质和细胞的有机成分以及包括汗液和机械力的物理因素的存在下，抗微生物组合物在生物和非生物表面上持续存在的能力;（B）在复杂表面如手和手套上实现污染病原体的快速灭活;和（c）确保组合物的生物相容性和用简单的洗涤步骤去除。 为了应对这些挑战，这项拟议的研究旨在在以下技术领域进行创新：（a）发现细胞组合物和工艺工程以稳定多种抗微生物剂并保持病原体的快速灭活（B）开发自然启发的设计以将基于细胞的抗微生物组合物保留在皮肤表面上以保持持久的抗微生物活性（c）工程化聚合物组合物以保留细胞-和（d）工程化细胞组合物以实现这些病原体的快速灭活。这可以根据载体组合物对病原体的工程亲和力以及细胞载体中抗菌剂的释放率来实现。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的评估被认为值得支持影响审查标准。