CAREER: Examining Prenatal and Postnatal Influences on Infant Brain Development

职业：检查产前和产后对婴儿大脑发育的影响

• 批准号: 2042285
• 负责人: Kathryn Humphreys
• 金额: $ 65万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2042285&HistoricalAwards=false
• 关键词: CAREER; Examining; Prenatal; Postnatal; Influences

This project explores the influence of stressful experiences and supportive caregiving on the developing brain. Given the dramatic growth that occurs during the prenatal and early postnatal periods, the brain seems especially sensitive to the environment during these months. Understanding when and how exposure to stress shapes the brain is essential for advancing knowledge about long-term health and functioning. This research will address fundamental questions regarding infant brain plasticity and provide insights that can be used to inform prevention and intervention efforts for children at risk for stress exposure in early life. Stressful experiences influence neurodevelopment in a manner that contributes to risks of emotional difficulties. Exposure to stress, even prenatally, may result in lasting changes in brain development. In this longitudinal study, following infants through early childhood, repeated assessments of infant brain structure and function will allow investigators to examine how prenatal stress exposure as well as measures of the subsequent caregiving environment serve as risk and protective factors in changes in the developing brain. During this period of heightened neuroplasticity the brain may be particularly vulnerable to the effects of stress, but also highly responsive to supportive caregiving experiences. Understanding how the brain changes in response to the early environment, particularly in a manner that explains links to later emotional difficulties, will provide new insight into when interventions may be most needed to support children in healthy development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个项目探讨了压力经历和支持性的成长对大脑发育的影响。由于在产前和产后早期发生的戏剧性增长，大脑似乎对这几个月的环境特别敏感。了解暴露于压力下何时以及如何塑造大脑对于促进长期健康和功能的知识至关重要。这项研究将解决有关婴儿大脑可塑性的基本问题，并提供可用于为早期生活中有压力暴露风险的儿童提供预防和干预措施的见解。压力体验影响神经发育的方式，有助于情绪困难的风险。暴露在压力下，即使是在产前，也可能导致大脑发育的持久变化。在这项纵向研究中，通过对婴儿早期的跟踪，对婴儿大脑结构和功能的反复评估将使研究人员能够研究产前压力暴露以及随后的分娩环境的测量如何成为发育中大脑变化的风险和保护因素。在神经可塑性增强的时期，大脑可能特别容易受到压力的影响，但对支持性护理体验也有高度反应。了解大脑如何在早期环境中变化，特别是在解释与后来的情绪困难的联系的方式，将提供新的见解，当干预措施可能是最需要的，以支持儿童的健康发展。这个奖项反映了NSF的法定使命，并已被认为是值得通过评估使用基金会的智力价值和更广泛的影响审查标准的支持。

项目成果

Benevolent Childhood Experiences and Childhood Maltreatment History: Examining their Roles in Depressive Symptoms Across the Peripartum Period.

• DOI: 10.1007/s42844-022-00062-0
• 发表时间: 2022-06
• 期刊: Adversity and resilience science
• 作者: Cardenas, Emilia F.;Kujawa, Autumn;Humphreys, Kathryn L.
• 通讯作者: Humphreys, Kathryn L.

Caregivers' positive emotion socialization tendencies are associated with positive affect in preschool age children.

照顾者的积极情绪社会化倾向与学龄前儿童的积极情绪相关。

• DOI: 10.1002/imhj.22036
• 发表时间: 2023
• 期刊: Infant mental health journal
• 影响因子: 2.4
• 作者: Hill,KaylinE;Kujawa,Autumn;Humphreys,KathrynL
• 通讯作者: Humphreys,KathrynL

Biomarker adoption in developmental science: A data-driven modelling of trends from 90 biomarkers across 20 years.

发育科学中生物标志物的采用：对 20 年来 90 种生物标志物的趋势进行数据驱动建模。

• DOI: 10.1002/icd.2366
• 发表时间: 2024
• 期刊: Infant and child development
• 影响因子: 2.2
• 作者: Qian,Weiqiang;Zhang,Chao;Piersiak,HannahA;Humphreys,KathrynL;Mitchell,Colter
• 通讯作者: Mitchell,Colter

What's the matter with ACEs? Recommendations for considering early adversity in educational contexts

ACE 出了什么问题？

• DOI: 10.1016/j.chiabu.2023.106073
• 发表时间: 2023
• 期刊: Child Abuse & Neglect
• 影响因子: 4.8
• 作者: Compton, Alisha B.;Panlilio, Carlomagno C.;Humphreys, Kathryn L.
• 通讯作者: Humphreys, Kathryn L.

Neural and behavioral indicators of cognitive control in preschoolers with and without prenatal opioid exposure

有或没有产前阿片类药物暴露的学龄前儿童认知控制的神经和行为指标

• DOI: 10.1080/09297049.2023.2196397
• 发表时间: 2023
• 期刊: Child Neuropsychology
• 影响因子: 2.2
• 作者: Cárdenas, Emilia F.;Hill, Kaylin E.;Estes, Elizabeth;Ravi, Sanjana;Molnar, Andrew E.;Humphreys, Kathryn L.;Kujawa, Autumn
• 通讯作者: Kujawa, Autumn