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Investigation of possible causal relationships between disc and facet joint degeneration using in-vivo, in vitro and finite element analyses

使用体内、体外和有限元分析研究椎间盘和小关节退变之间可能的因果关系

基本信息

批准号：
245402226
负责人：
Professor Dr. Hans-Joachim Wilke
金额：
--
依托单位：
Institut für Unfallchirurgische Forschung und Biomechanik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/245402226?language=en
关键词：
Investigation possible causal relationships between

项目摘要

The degeneration of the intervertebral disc and the facet joints is one major reason for specific low back pain which can be induced, among other factors, by inappropriate mechanical stresses and overloading. It is still a matter of debate which structure is affected first by degenerative processes and whether a correlation exists between both. This knowledge, however, is crucial for the choice of appropriate treatment strategies. It provides basic know-how to optimize the development of spinal implants and helps to take a decision regarding the indication of fusion or motion-preserving implants.The aim of this research project is to clarify the course of degeneration within a functional spinal unit using an in vivo, in vitro and in silico approach. The in vivo animal experiment on sheep will be used to initiate an intervertebral disc and/or facet joint degeneration by performing various surgical procedures. Over a period of one year, the mutual influence of each of the subsequent degenerative changes will be investigated. The following in vitro experiments will be used to detect morphological changes within affected segments and to implement realistic geometry and material parameters into the developed finite element models. The finite element analyzes will offer valuable clues about the course of degenerative processes in humans taking into account individual spine morphologies and try to elucidate alleged mechanical correlations between pathologic changes of the intervertebral disc and the facet joints.

椎间盘和小关节的退变是引起特殊腰痛的主要原因之一，这种疼痛可能是由不适当的机械应力和超负荷等因素引起的。哪种结构最先受到退化过程的影响，以及两者之间是否存在相关性，仍是一个有争议的问题。然而，这些知识对于选择适当的治疗策略是至关重要的。它提供了优化脊柱植入物发展的基本知识，并帮助决定融合或保留运动的植入物的适应症。本研究项目的目的是通过体内、体外和硅胶方法阐明功能脊柱单位内的退化过程。在绵羊身上的活体动物实验将被用来通过执行各种手术程序来启动椎间盘和/或小关节退变。在为期一年的时间里，将调查随后的每一次退化变化的相互影响。以下体外实验将用于检测受影响节段内的形态变化，并将真实的几何和材料参数应用到开发的有限元模型中。有限元分析将为人类退变过程提供有价值的线索，同时考虑到个体脊柱的形态，并试图阐明椎间盘和小关节的病理变化之间所谓的力学相关性。