Investigation of possible causal relationships between disc and facet joint degeneration using in-vivo, in vitro and finite element analyses

使用体内、体外和有限元分析研究椎间盘和小关节退变之间可能的因果关系

基本信息

项目摘要

The degeneration of the intervertebral disc and the facet joints is one major reason for specific low back pain which can be induced, among other factors, by inappropriate mechanical stresses and overloading. It is still a matter of debate which structure is affected first by degenerative processes and whether a correlation exists between both. This knowledge, however, is crucial for the choice of appropriate treatment strategies. It provides basic know-how to optimize the development of spinal implants and helps to take a decision regarding the indication of fusion or motion-preserving implants.The aim of this research project is to clarify the course of degeneration within a functional spinal unit using an in vivo, in vitro and in silico approach. The in vivo animal experiment on sheep will be used to initiate an intervertebral disc and/or facet joint degeneration by performing various surgical procedures. Over a period of one year, the mutual influence of each of the subsequent degenerative changes will be investigated. The following in vitro experiments will be used to detect morphological changes within affected segments and to implement realistic geometry and material parameters into the developed finite element models. The finite element analyzes will offer valuable clues about the course of degenerative processes in humans taking into account individual spine morphologies and try to elucidate alleged mechanical correlations between pathologic changes of the intervertebral disc and the facet joints.
椎间盘和小关节的退变是特定腰痛的一个主要原因,其可以由不适当的机械应力和过载等因素引起。这仍然是一个争论的问题,结构首先受到退化过程,以及两者之间是否存在相关性。然而,这些知识对于选择适当的治疗策略至关重要。它提供了优化脊柱植入物开发的基本知识,并有助于决定融合或保留运动的植入物的适应症。该研究项目的目的是使用体内、体外和计算机模拟方法阐明功能性脊柱单位内的退变过程。绵羊的体内动物实验将用于通过执行各种外科手术来引发椎间盘和/或小关节退变。在一年的时间里,将调查随后的每一个退行性变化的相互影响。以下体外实验将用于检测受影响节段内的形态学变化,并将真实的几何形状和材料参数应用到开发的有限元模型中。有限元分析将提供有价值的线索,考虑到个人的脊柱形态,并试图阐明所谓的机械椎间盘和小关节的病理变化之间的相关性的过程中,人类的退行性过程。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Is the sheep a suitable model to study the mechanical alterations of disc degeneration in humans? A probabilistic finite element model study.
绵羊是研究人类椎间盘退变机械变化的合适模型吗?
  • DOI:
    10.1016/j.jbiomech.2018.12.042
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Bashkuev;Reitmaier;Sandra;Schmidt;Hendrik
  • 通讯作者:
    Hendrik
Impact of material and morphological parameters on the mechanical response of the lumbar spine - A finite element sensitivity study.
  • DOI:
    10.1016/j.jbiomech.2016.12.014
  • 发表时间:
    2017-02
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    T. Zander;M. Dreischarf;Anne-Katrin Timm;W. Baumann;H. Schmidt
  • 通讯作者:
    T. Zander;M. Dreischarf;Anne-Katrin Timm;W. Baumann;H. Schmidt
Increase or decrease in stability after nucleotomy? Conflicting in vitro and in vivo results in the sheep model
核切除术后稳定性增加还是减少?
  • DOI:
    10.1098/rsif.2014.0650
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Reitmaier S;Volkheimer D;Berger-Roscher N;Wilke H-J;Ignatius A
  • 通讯作者:
    Ignatius A
Spinal fusion without instrumentation – Experimental animal study
无器械脊柱融合 â 实验动物研究
  • DOI:
    10.1016/j.clinbiomech.2017.04.008
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    1.8
  • 作者:
    Reitmaier S;Schuelke J;Schmidt H;Volkheimer D;Ignatius A;Wilke HJ
  • 通讯作者:
    Wilke HJ
Three-dimensional microstructural reconstruction of the ovine intervertebral disc using ultrahigh field MRI.
利用超高场 MRI 重建绵羊椎间盘的三维微观结构
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Professor Dr. Hans-Joachim Wilke其他文献

Professor Dr. Hans-Joachim Wilke的其他文献

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{{ truncateString('Professor Dr. Hans-Joachim Wilke', 18)}}的其他基金

Biomechanical analysis of surgical scoliosis treatments
脊柱侧弯手术治疗的生物力学分析
  • 批准号:
    422439870
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Biomechanics of the thoracic spine and the influence of the chest.
胸椎的生物力学和胸部的影响。
  • 批准号:
    274498276
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Frakturrisiko von Wirbelkörpern unter Berücksichtigung von inhomogenen Dichteverteilungen und lokal unterschiedlichen Trabekelausrichtungen
考虑到不均匀的密度分布和局部不同的小梁排列,椎体骨折的风险
  • 批准号:
    65432550
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Entwicklung eines in vitro- und Finite-Element-Modells (FE-Modells) für biomechanische Skolioseuntersuchungen
开发用于生物力学脊柱侧弯研究的体外有限元模型(FE 模型)
  • 批准号:
    46772434
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Beurteilung bandscheibenerhaltender Operationstechniken anhand der Bandscheibenauswölbung
基于椎间盘膨出情况的椎间盘保留手术技术评估
  • 批准号:
    27295831
  • 财政年份:
    2006
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Multiscale Simulation and Validation of the Elastic Microstructure of Vertebral Bodies
椎体弹性微观结构的多尺度模拟与验证
  • 批准号:
    5446341
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Trägermaterialien, Klebeschichten, biochemische Funktionalisierung und Zellbesiedlung von neuartigen, flocktechnologisch erzeugten Scaffolds
使用植绒技术生产的新型支架的载体材料、粘合层、生化功能化和细胞定植
  • 批准号:
    5430234
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Interkorporelle Fusion durch transpedikuläre Applikation eines Komposits aus Kalziumphosphat und Bone-Morphogenetic-Protein an der Lendenwirbelsäule des Schafs
通过椎弓根将磷酸钙和骨形态发生蛋白复合物应用于绵羊腰椎的椎间融合
  • 批准号:
    5406518
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Determination of local stresses in healthy, degenerated and iatrogenic intervertebral discs during pure and complex loading
纯负载和复杂负载期间健康、退化和医源性椎间盘局部应力的测定
  • 批准号:
    5409448
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Experimentelle Bestimmung von Verletzungskriterien und -level für das HWS-Schleudertrauma unter Berücksichtigung der Oberkörperbewegung und der Halsmuskulatur
考虑上身运动和颈部肌肉,通过实验确定颈椎扭伤的损伤标准和水平
  • 批准号:
    5344804
  • 财政年份:
    2001
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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研究大西洋深海山形态的周期性:地幔动力学的可能证据
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Investigation of the early evolutionary process of the unique defensive organs of snakes that utilized sequestered toxins from prey: Possible diversification in ancestral species
研究蛇利用猎物中的隔离毒素的独特防御器官的早期进化过程:祖先物种的可能多样化
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The Enteric Glia as a Possible Target for Symptom Relief in Endometriosis
肠胶质细胞作为缓解子宫内膜异位症症状的可能目标
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Elucidation of possible factors affecting the "range" of growth temperatures in a temperature fluctuating environment.
阐明在温度波动的环境中影响生长温度“范围”的可能因素。
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HYDRA:氢经济的好处和风险:减轻可能的气候影响的工具开发和政策实施
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