Biomechanics of the thoracic spine and the influence of the chest.

胸椎的生物力学和胸部的影响。

• 批准号: 274498276
• 负责人: Professor Dr. Hans-Joachim Wilke
• 金额: --
• 依托单位: Institut für Unfallchirurgische Forschung und Biomechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/274498276?language=en
• 关键词: Biomechanics; thoracic; spine; influence; chest.

The rib cage is assumed to have a strong influence on the stability and flexibility of the human thoracic spine. The magnitude of this influence and the relevance of the different structures are poorly understood. Therefore it is vague as to which is the best strategy for the treatment of fractures, deformations, and degenerations in the thoracic spine. If thoracic fractures are not stabilized sufficiently, the consequence may be loss of correction. However, it is not known how many segments of the thoracic spine are needed to be stabilized in case of vertebral body fractures and subsequent restabilisation by vertebral replacement implants and dorsal instrumentation using pedicle screw-rod systems. The operative treatment of serial rib fractures is also discussed. Moreover, the ribs and other structures resected during scoliosis surgery are mostly chosen empirically, potentially leading to instabilities of the spine. The influence of these different resection strategies on the stability of the thoracic spine is not understood well enough. Biomechanical in vitro experiments with thoracic spine specimens were mostly performed without the rib cage, which lead to unrepresentative data and difficulties interpreting the results. Finite element models or multi-body models including the rib cage have critical limitations due to the unknown biomechanical properties of the ribcage.The purpose of the extension of this project is to understand and quantify, in detail, the biomechanics and importance of all relevant structures of the thoracic spine and rib cage. This is accomplished by performing several biomechanical in vitro studies on thoracic spines with and without the rib cage, implementing multiple resection steps. Using this generated biomechanical data and morphological analyses of the corresponding anatomical structures, a parameterized finite element model of the human thoracic spine including the rib cage will be generated, calibrated, and validated. Subsequently preliminary investigations to answer clinically relevant questions will be performed in vitro and using the generated finite element model..

假定肋骨对人胸脊柱的稳定性和柔韧性具有很大的影响。这种影响的大小和不同结构的相关性知之甚少。因此，对于胸椎骨折，变形和变性的治疗的最佳策略是模糊的。如果胸腔骨折未充分稳定，则可能是校正丧失。但是，尚不清楚在椎体骨折的情况下需要稳定多少个胸椎脊柱，然后使用椎弓根螺钉杆系统通过椎骨替换植入物和背侧仪器进行重新定位。还讨论了连续肋骨骨折的手术治疗。此外，脊柱侧弯手术过程中切除的肋骨和其他结构主要是经验选择的，可能导致脊柱不稳定。这些不同的切除策略对胸椎稳定性的影响还不够好。对胸部脊柱标本的生物力学体外实验主要是在没有肋骨笼的情况下进行的，这会导致不代表性的数据和解释结果的困难。由于未知的生物力学特性，该项目扩展的目的是详细理解和量化胸脊柱和肋骨的所有相关结构的生物力学和重要性。这是通过对有或没有肋骨笼的胸椎进行几项生物力学的体外研究来实现的，从而实现了多个切除步骤。使用这种生成的生物力学数据和相应解剖结构的形态分析，将生成，校准和验证的人类胸部脊柱的参数化有限元模型。随后，将在体外进行初步研究以回答临床相关问题，并使用生成的有限元模型进行。