Biomechanics of the thoracic spine and the influence of the chest.

胸椎的生物力学和胸部的影响。

• 批准号: 274498276
• 负责人: Professor Dr. Hans-Joachim Wilke
• 金额: --
• 依托单位: Institut für Unfallchirurgische Forschung und Biomechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/274498276?language=en
• 关键词: Biomechanics; thoracic; spine; influence; chest.

The rib cage is assumed to have a strong influence on the stability and flexibility of the human thoracic spine. The magnitude of this influence and the relevance of the different structures are poorly understood. Therefore it is vague as to which is the best strategy for the treatment of fractures, deformations, and degenerations in the thoracic spine. If thoracic fractures are not stabilized sufficiently, the consequence may be loss of correction. However, it is not known how many segments of the thoracic spine are needed to be stabilized in case of vertebral body fractures and subsequent restabilisation by vertebral replacement implants and dorsal instrumentation using pedicle screw-rod systems. The operative treatment of serial rib fractures is also discussed. Moreover, the ribs and other structures resected during scoliosis surgery are mostly chosen empirically, potentially leading to instabilities of the spine. The influence of these different resection strategies on the stability of the thoracic spine is not understood well enough. Biomechanical in vitro experiments with thoracic spine specimens were mostly performed without the rib cage, which lead to unrepresentative data and difficulties interpreting the results. Finite element models or multi-body models including the rib cage have critical limitations due to the unknown biomechanical properties of the ribcage.The purpose of the extension of this project is to understand and quantify, in detail, the biomechanics and importance of all relevant structures of the thoracic spine and rib cage. This is accomplished by performing several biomechanical in vitro studies on thoracic spines with and without the rib cage, implementing multiple resection steps. Using this generated biomechanical data and morphological analyses of the corresponding anatomical structures, a parameterized finite element model of the human thoracic spine including the rib cage will be generated, calibrated, and validated. Subsequently preliminary investigations to answer clinically relevant questions will be performed in vitro and using the generated finite element model..

胸腔被认为对人体胸椎的稳定性和灵活性有很大的影响。这种影响的程度和不同结构的相关性知之甚少。因此，对于胸椎骨折、变形和变性的最佳治疗策略，目前尚不明确。如果胸椎骨折没有得到足够的稳定，后果可能是矫正丢失。然而，目前尚不清楚在椎体骨折的情况下需要稳定多少胸椎节段，随后通过椎体置换植入物和使用椎弓根螺钉-棒系统的背侧器械进行再稳定。本文还讨论了连续肋骨骨折的手术治疗。此外，在脊柱侧凸手术期间切除的肋骨和其他结构大多是凭经验选择的，这可能导致脊柱的不稳定。这些不同的切除策略对胸椎稳定性的影响还不够清楚。胸椎标本的体外生物力学实验大多在没有肋骨架的情况下进行，这导致数据不具有代表性并且难以解释结果。有限元模型或多体模型，包括肋骨架有严重的局限性，由于未知的生物力学性能的肋骨架。本项目的扩展的目的是了解和量化，详细，生物力学和重要性的所有相关结构的胸椎和肋骨架。这是通过对有和没有肋骨架的胸椎进行几项生物力学体外研究，实施多个切除步骤来实现的。使用生成的生物力学数据和相应解剖结构的形态学分析，将生成、校准和确认人体胸椎（包括胸腔）的参数化有限元模型。随后，将在体外使用生成的有限元模型进行初步研究，以回答临床相关问题。