Measurement of In Situ Mechanical Forces During Neotissue Formation
新组织形成过程中原位机械力的测量
基本信息
- 批准号:2054193
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This grant will use tiny force sensors to measure the forces that exist during the earliest stages of tissue formation and for the maturation stages that follow. The push and pull of cells on each other are a critical part of biological development and tissue formation. This is particularly true for the growth of muscles, bones, and connective tissues in our bodies. Cells are stimulated by these local forces, responding in ways that help create the complex structures needed for more mature tissues to function properly. Direct measurement of cellular-scale forces is difficult, particularly in cell-dense, 3D samples. The information gained from this work will fill a knowledge gap in developmental biology and tissue regeneration. The research team will include a diverse group of undergraduate and graduate students, in addition to local public school teachers, who will be central to our outreach efforts in communicating the importance of interdisciplinary research to high school students.To accomplish our goals, two objectives have been established. First, we will determine how the physical characteristics of our cellular-scale force probes influence measurements in a model system of tissue formation. This includes the size, stiffness, and chemical coating of the probes. Second, we will investigate how local mechanical forces change over time as cartilage-like and tendon/ligament-like neotissues form and mature. These studies will provide completely new insight on the relevance of forces in cell-dense biological structures, benefiting fields as diverse as developmental biology and tissue engineering.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项资助将使用微小的力传感器来测量组织形成的最早阶段和随后的成熟阶段存在的力。细胞之间的相互推拉是生物发育和组织形成的关键部分。这对于我们身体中肌肉、骨骼和结缔组织的生长尤其如此。细胞受到这些局部力量的刺激,以帮助创造更成熟组织正常运作所需的复杂结构的方式做出反应。直接测量细胞尺度的力是困难的,特别是在细胞密集的3D样品中。从这项工作中获得的信息将填补发育生物学和组织再生方面的知识空白。研究团队将包括本科生和研究生的多元化群体,除了当地公立学校的教师,谁将是我们的外展工作,在沟通跨学科研究的重要性,以高中生的核心。为了实现我们的目标,两个目标已经建立。首先,我们将确定我们的细胞规模的力探针的物理特性如何影响组织形成的模型系统中的测量。这包括探针的尺寸、硬度和化学涂层。其次,我们将研究如何随着时间的推移,局部机械力的变化,软骨样和肌腱/韧带样新组织的形成和成熟。这些研究将为细胞密集生物结构中力的相关性提供全新的见解,使发育生物学和组织工程等不同领域受益。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric Darling其他文献
Eric Darling的其他文献
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{{ truncateString('Eric Darling', 18)}}的其他基金
EAGER: Biomanufacturing: Gene expression-based standardization of stem cells
EAGER:生物制造:基于基因表达的干细胞标准化
- 批准号:
1547819 - 财政年份:2015
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
CAREER: Mechanical Biomarkers and Mesenchymal Stem Cell Differentiation
职业:机械生物标志物和间充质干细胞分化
- 批准号:
1253189 - 财政年份:2013
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
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