Transmission of traumatic childhood experiences across generations: mother-child interaction in traumatized mothers with borderline personality disorder

童年创伤经历的代代相传：患有边缘性人格障碍的受创伤母亲的母子互动

• 批准号: 246596363
• 负责人: Professor Dr. Felix Bermpohl
• 金额: --
• 依托单位: Psychiatrische Universitätsklinik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/246596363?language=en
• 关键词: Transmission; traumatic; childhood; experiences; across

Childhood traumatic experiences (CT) are often transmitted across generations. An estimated 25% of abused children are likely to become abusive parents themselves. CT will here be defined as physical or sexual abuse experienced before the age of 17. The question arises which behavioral and neurobiological mechanisms underlie the transmission of abuse. Individuals differ in the way they react to CT. Two common reactions are borderline personality disorder (BPD) and depression (major depressive disorder, MDD). They represent externalizing (BPD) versus internalizing (MDD) styles of reaction to trauma. These variations in reactions to trauma may be critical for how CT are transmitted across generations and how transmission could be prevented.While some studies have investigated effects of maternal MDD on mother-child interaction, little attention has been paid to the effects of maternal BPD. Here we focus on a group that has not yet been studied: mothers who have responded to CT with BPD and their children of primary school age. They will be compared with traumatized mothers without BPD and with BPD mothers without CT. Our primary research question is: What are the specific effects of BPD psychopathology and of CT on mother-child interaction and how do these two factors interact?Data obtained in the proposed project will be compared with data from an ongoing BMBF project which is applying a similar test battery. In this BMBF project, we investigate mothers showing depressive reactions to CT, non-traumatized mothers with MDD and healthy mothers without CT. Our secondary research question is: Do effects of CT on mother-child interaction depend on the maternal reaction to trauma? To study the transgenerational transmission of CT we will combine behavioral observations of mother-child interaction using the emotional availability scale, functional magnetic resonance imaging (fMRI) and endocrinology. Particular emphasis will be placed on (1) maternal hostility and (2) child involvement with the mother during a free-play interaction and during a stress paradigm. Regarding the mother, we hypothesize: Both CT and BPD are associated with increased hostility, and the effects add up in mothers with both factors. Increased hostility is moderated by oxytocin and cortisol and is associated with amygdala hyper-responsiveness and hypo-active prefrontal emotion regulation networks during a maternal stress (anger) paradigm. In contrast, mothers responding to CT with MDD show decreased sensitivity. Regarding the child, we hypothesize: Both maternal CT and maternal BPD are associated with reduced child involvement with the mother, and the effects add up in children of mothers with both factors. In contrast, children of mothers responding to CT with MDD show over-involvement. This project contributes to our understanding of the transgenerational cycle of abuse and allows the identification of disorder-specific targets for intervention.

童年创伤经历（CT）通常会代代相传。据估计，25%的受虐待儿童自己可能成为虐待儿童的父母。在此，CT将被定义为17岁之前经历的身体或性虐待。由此产生的问题是，哪些行为和神经生物学机制是虐待传播的基础。每个人对CT的反应不同。两种常见的反应是边缘型人格障碍（BPD）和抑郁症（重度抑郁症，MDD）。它们代表了对创伤的外化（BPD）与内化（MDD）反应方式。这些变化的反应，创伤可能是至关重要的CT是如何跨代传播，以及如何传输可以prevent.While一些研究调查了母亲MDD对母子互动的影响，很少有人注意到母亲BPD的影响。在这里，我们专注于一组尚未被研究：母亲谁与BPD和他们的孩子的小学年龄的CT响应。他们将与没有BPD的创伤母亲和没有CT的BPD母亲进行比较。我们的主要研究问题是：BPD精神病理学和CT对母婴互动的具体影响是什么？这两个因素是如何相互作用的？在拟议项目中获得的数据将与正在进行的BMBF项目的数据进行比较，该项目正在使用类似的测试组合。在这个BMBF项目中，我们调查了对CT表现出抑郁反应的母亲，患有MDD的非创伤母亲和没有CT的健康母亲。我们的第二个研究问题是：CT对母婴互动的影响是否取决于母亲对创伤的反应？为了研究CT的跨代传递，我们将使用情绪可用性量表、功能性磁共振成像（fMRI）和内分泌学结合联合收割机对母子互动的行为观察。特别强调的是（1）母亲的敌意和（2）儿童参与与母亲在一个自由发挥的互动，并在一个压力的范例。关于母亲，我们假设：CT和BPD都与增加的敌意有关，并且在两种因素的母亲中效果相加。增加的敌意是由催产素和皮质醇调节，并与杏仁核高反应性和低活性的前额叶情感调节网络在母亲的压力（愤怒）的范例。与此相反，对CT有反应的MDD母亲显示敏感性降低。关于孩子，我们假设：母亲的CT和母亲的BPD都与孩子与母亲的参与减少有关，并且这种影响在具有这两种因素的母亲的孩子中叠加。与此相反，儿童的母亲回应CT与MDD显示过度参与。该项目有助于我们了解跨代虐待循环，并允许确定干预的特定目标。

项目成果

Early life maltreatment but not lifetime depression predicts insecure attachment in women

早年遭受虐待而非终生抑郁预示着女性的不安全依恋

• DOI: 10.1007/s00737-017-0731-z
• 发表时间: 2017
• 期刊: Archives of Women's Mental Health
• 作者: Zietlow;Nonnenmacher;Mueller;Herpertz;Neukel;Bermpohl;Fuehrer;Kluczniok;Hindi Attar;Dittrich;Boedeker
• 通讯作者: Boedeker

Observational Context of Mother-Child Interaction: Impact of a stress Context on Emotional Availability

• DOI: 10.1007/s10826-017-0678-8
• 发表时间: 2017-06-01
• 期刊: JOURNAL OF CHILD AND FAMILY STUDIES
• 影响因子: 2.1
• 作者: Dittrich, Katja;Fuchs, Anna;Boedeker, Katja
• 通讯作者: Boedeker, Katja