The contact system in liver inflammation – interface of inflammation, coagulation and innate immunity (B08)

多磷酸盐/因子XII驱动的接触系统提供了一个范例，以阐明促炎和促凝血机制。我们的目的是分析功能的多磷酸盐/因子XII轴在炎症，免疫，感染和恶性肝病。我们的翻译建议包括转基因小鼠与缺陷的聚磷酸盐/因子XII-途径和系统生物学为基础的分析人类肝脏疾病的转录组。我们的研究总结将提高我们对多磷酸盐/因子XII驱动的接触系统在肝脏疾病状态中的贡献及其作为潜在药物靶点的作用的理解。

The polyphosphate/factor XII-driven contact system provides a paradigm to elucidate proinflammatory and procoagulant mechanisms. We aim to analyse functions of the polyphosphate/factor XII-axis in inflammatory, immune, infectious, and malignant liver diseases. Our translational proposal comprises transgenic mice with deficiencies in the polyphosphate/factor XII-pathway and systems biology-based analyses of human liver diseases transcriptomes. The sum of our studies will improve our understanding on the contributions of the polyphosphate/factor XII-driven contact system in liver disease states and its role as potential drug target.