RUI: Development of Novel Plasmonic Nanotransducers for Solution-based Molecular Imprinted Sensing

RUI：开发用于基于溶液的分子印迹传感的新型等离子体纳米传感器

• 批准号: 2108842
• 负责人: Ying Bao
• 金额: $ 36.65万
• 依托单位: Western Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2108842&HistoricalAwards=false
• 关键词: RUI; Development; Novel; Plasmonic; Nanotransducers

With the support of the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Dr. Ying Bao of Western Washington University is studying the development and implementation of a new class of nanoparticle-based sensors, which detect tiny amounts of biological molecules in solution. Metal nanoparticles that can be made to have waves of electrons on their surfaces by shining light on the particles are called plasmonic nanoparticles. The energy at which the electron waves are formed is dependent on the density of materials close to the surface of the plasmonic nanoparticles. Small changes in the type and density of the nearby materials cause a large change in the energy of the electron waves, that can be measured by the energy of the light absorbed by the metal nanoparticle. Such plasmonic nanoparticles will be made to detect very small numbers of protein molecules in solution by creating locations on the nanoparticles that bind to the proteins in a selective way and by placing these binding sites at locations on the nanoparticles that give the biggest change in the energy of the light that is absorbed. The selective nature of these "nanotransducers" is being achieved by making a molecular mold or imprint of proteins in a glass-like material. This molecular imprinting process creates physically robust and low-cost sensors capable of selectively binding to target molecules. This project will combine the benefits of individual plasmonic nanotransducers with molecular imprinting and open new avenues in nanosensor development. The fundamental principles that will be discovered in this research can be applied by researchers when developing the next generation of new plasmonic nanosensors, with applications in areas such as clinical diagnosis, food safety, and environmental monitoring. The project will provide opportunities for students in the Chemistry Department at Western Washington University to engage in nanomaterial-related research and gain experience in materials, environmental, and analytical chemistry. Furthermore, through both a course-based undergraduate research experience (CURE) and summer research positions, students at a local community college will gain nanoscience research experience. To develop and implement a new class of anisotropic plasmonic nanotransducers permitting solution-based molecular imprinted sensing, this project is focused on three main objectives: 1) Synthesis and fundamental study of novel plasmonic nanotransducers. 2) Performing molecular imprinting of plasmonic nanotransducers in solution. 3) Evaluating sensing properties of imprinted nanosensors in solution. Methods for site-specific deposition of silica on plasmonic nanorods, as well as methods for controlling growth of nanoscale "tentacle" features will be used and further modified to produce this novel class of anisotropic plasmonic nanotransducer. The development of such nanotransducers could address key shortcomings of existing plasmonic nanomaterials for molecular imprint-based sensing, most prominently their low stability in solution and limited effective surface area. Applying molecular imprinting and sensing in solution also has the possibility to address important restrictions in substrate-based (planar) systems, including limited numbers of imprinted molecular recognition sites, attrition in the number of sensors connected to the substrate, reduced refractive index sensitivity due to immobilization of the nanoparticles, and restricted flexibility on adjusting the number and types of nanosensors in the sensing system. The proposed fundamental studies have the potential to provide useful information for the improved design of nano-transducers and imprinted plasmonic nanosensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学划分中的化学测量和成像计划（CMI）计划的支持下，西华盛顿大学的Ying Bao博士正在研究一种新的基于纳米粒子的传感器的开发和实施，该传感器检测到溶液中的少量生物分子。 可以通过在颗粒上发光的光在其表面上具有电子波的金属纳米颗粒称为等离激元纳米颗粒。 形成电子波的能量取决于靠近等离子纳米颗粒表面的材料的密度。 附近材料的类型和密度的微小变化会导致电子波能量的巨大变化，这可以通过金属纳米颗粒吸收的光能来测量。 通过在纳米颗粒上创建与蛋白质结合的位置，并将这些结合位点放置在纳米颗粒上的位置，从而在纳米颗粒的位置上，从而在纳米颗粒上产生与蛋白质结合的纳米颗粒，从而使这种等离子纳米颗粒在溶液中检测到很少的蛋白质分子，从而在纳米颗粒的位置放置这些结合位点，从而在光吸收的光能中最大的变化。 这些“纳米传递器”的选择性是通过在玻璃样材料中制作分子模具或蛋白质的烙印来实现的。 这个分子印迹过程会产生能够选择性结合靶分子的身体稳健和低成本传感器。 该项目将将单个等离子纳米传递器的好处与纳米传感器开发中的分子印记和开放新途径相结合。 研究人员可以在开发下一代新的等离激元纳米传感器时应用在这项研究中发现的基本原理，并在临床诊断，食品安全和环境监测等领域中应用。 该项目将为西华盛顿大学化学系的学生提供机会，从而从事与纳米材料相关的研究并获得材料，环境和分析化学方面的经验。 此外，通过基于课程的本科研究经验（CURE）和夏季研究职位，当地社区学院的学生将获得纳米科学研究经验。为了开发和实施一类新的各向异性等离激元纳米传递器，允许基于溶液的分子印记感应，该项目集中在三个主要目标上：1）新型等离激元纳米传输器的合成和基本研究。 2）在溶液中对等离子体纳米传递剂的分子印迹。 3）评估溶液中印迹纳米传感器的传感特性。将使用并进一步修改二氧化硅在等离激元纳米棒上的位点特异性沉积方法，以及控制纳米级“触手”特征的生长的方法，以生产这种新型各向异性等离激源性纳米透射剂。 这种纳米传递剂的发展可以解决基于分子烙印的传感的现有等离子纳米材料的主要缺点，最突出的是它们在溶液中的低稳定性和有限的有效表面积。 在溶液中应用分子烙印和传感也有可能解决基于底物（平面）系统的重要限制，包括有限数量的分子识别位点，与底物相关的传感器数量的磨损，降低了由于固定剂的固定性固定型和限制性的柔韧性和调整数字的折射式指数敏感性，并在NINAMOPERTICS上进行了限制性的挠性。 拟议的基本研究有可能为改进的纳米透射剂和烙印的等离子纳米传感器的设计提供有用的信息。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准通过评估来进行评估的。

项目成果

Impact on the Formation and Catalytic Property of Pt-Based Nanocatalysts by Galvanic Reaction with Co-Reduction Agents

• DOI: 10.1021/acs.chemmater.2c02659
• 发表时间: 2022-10
• 期刊: Chemistry of Materials
• 影响因子: 8.6
• 作者: John R. Crockett;Maggie Wang;Joseph E. Doebler;Tejal Pawale;Xiao Li;Ying Bao

Recent advances in surface modified gold nanorods and their improved sensing performance

• DOI: 10.1039/d3cc04056a
• 发表时间: 2023-12-07
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Bao，Ying;Oluwafemi，Ayomide
• 通讯作者: Oluwafemi，Ayomide