STTR Phase I: Broad Spectrum Antimicrobial Surface Coating (COVID-19)

STTR 第一阶段：广谱抗菌表面涂层 (COVID-19)

• 批准号: 2112033
• 负责人: Dana Totir
• 金额: $ 25.6万
• 依托单位: NANOIONIX, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2112033&HistoricalAwards=false
• 关键词: STTR; Phase; Broad; Spectrum; Antimicrobial

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to minimize the number of hospital-associated infections which contribute to almost 100,000 deaths each year in the US at an annual cost exceeding $30 B. Reducing the surface-borne transmission of pathogens can limit the spread of pathogenic diseases, thus minimizing transmission from contaminated surfaces in both public and healthcare settings is of utmost importance. Disinfectants can inactivate pathogens but require an active engagement that places undue burden on personnel and the environment; furthermore, the success rate varies, and the results do not persist. Most current antimicrobial materials are expensive, toxic to humans and the environment, and show minimal viral inactivation. Self-decontaminating surfaces provide a much-needed solution to these limitations, especially in areas with high-touch surfaces and large population flow. Customers, from hardware and elevator manufacturers to hospitals and airlines, will benefit from an effective, low-cost, environmentally sound solution to decontamination and customer safety for conditions such as the current COVID-19 pandemic. This project has potential impact for the $8 B antimicrobial coatings market, while delivering improved clinical outcomes. This STTR Phase I project proposes to demonstrate the efficacy of a breakthrough, permanent ceramic coating technology against both viruses and bacteria. A pure ceramic coating that exceeds the Environmental Protection Agency’s (EPA’s) requirements will be synthesized and deposited on relevant substrates. The key to reaching this goal is gaining an understanding of the mechanism of microbial inactivation – believed to be the spontaneous generation of reactive oxygen species (ROS) on the surface of the ceramic – and how to maximize them in a practical coating. Spectroscopic techniques will be used to rapidly assess the number and type of ROS generated and thus the efficacy of the materials. Optimization will occur through the addition/substitution of targeted alkali, alkaline earth, transition, and/or main-group metals to control the lattice of the material and lock-in specific valence states to optimize the ability of the ceramic to generate large numbers of the appropriate reactive oxygen species. Tests will be performed against both viral and bacterial challenges to correlate the results of the rapid screening assessment with antimicrobial effectiveness. Pure ceramic thin films will be deposited, and the antimicrobial efficacy of these films tested.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业技术转移（STTR）项目的更广泛的影响/商业潜力是最大限度地减少医院相关感染的数量。在美国，医院相关感染每年导致近10万人死亡，每年的成本超过300亿美元。减少病原体的表面传播可以限制致病性疾病的传播，从而最大限度地减少公共和医疗机构中受污染表面的传播是至关重要的。消毒剂可以灭活病原体，但需要积极参与，这会给人员和环境带来不应有的负担；此外，成功率各不相同，结果也不能持久。目前大多数抗菌材料都很昂贵，对人类和环境有毒，而且病毒灭活能力很弱。自净化表面为这些限制提供了急需的解决方案，特别是在高接触表面和人口流动大的地区。从硬件和电梯制造商到医院和航空公司的客户，都将受益于有效、低成本、环保的去污和客户安全解决方案，以应对当前COVID-19大流行等情况。该项目将对80亿美元的抗菌涂料市场产生潜在影响，同时改善临床效果。这个STTR第一期项目旨在展示一种突破性的永久性陶瓷涂层技术对病毒和细菌的功效。将合成超过环境保护署（EPA）要求的纯陶瓷涂层并沉积在相关基材上。实现这一目标的关键是了解微生物失活的机制-被认为是在陶瓷表面自发产生活性氧(ROS) -以及如何在实际涂层中最大化它们。光谱技术将用于快速评估产生的活性氧的数量和类型，从而评估材料的功效。优化将通过添加/取代目标碱、碱土、过渡和/或主族金属来控制材料的晶格和锁定特定的价态，以优化陶瓷产生大量适当活性氧的能力。将针对病毒和细菌挑战进行测试，以将快速筛选评估的结果与抗菌效果联系起来。将沉积纯陶瓷薄膜，并测试这些薄膜的抗菌效果。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。