Antimicrobial Copper - Functional Surfaces and Factors of Toxicity
Antimicrobial Copper - Functional Surfaces and Factors of Toxicity
批准号:
247643033
负责人:
Professor Dr.-Ing. Frank Mücklich
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2013
资助国家:
德国
项目状态:
已结题
起止时间:
2012-12-31 至 2014-12-31
中文摘要
通过激光干涉表面结构精确调整表面参数、形貌和化学性质,在第一次提议中产生了细菌尺度的模型表面。使用这些,控制润湿,离子释放和细菌粘附在金属表面的表面参数进行了评估。此外,还对铜在细菌活力试验中的氧化行为以及激光熔覆铜与银的结合进行了实现和研究。调谐的材料和表面参数与这些表面的抗菌效率精确相关。这里描述的后续建议是由第一个建议的部分令人惊讶的结果所驱动的。这里的重点在于材料与细菌直接接触的作用,以及不同表面电位对接触杀灭的电化学影响。正如在第一个方案中定量显示的那样,细菌与金属表面之间的接触在很大程度上决定了杀灭率,因此在后续方案中将创建地形定制的铜表面。在这些问题上,将调查有效接触面积的变化是否以及如何影响杀伤率。在项目的第二部分,将通过激光干涉光刻和连续金属涂层来诱导具有控制电位差的化学表面图案。利用这些图案表面,通过材料组合和图案尺度的变化来研究电位差的影响。为了将其与抗菌效率联系起来,在所研究的表面上的细菌粘附将在显微镜下定量表征,与这些研究平行。鉴于危险细菌对抗生素的耐药性不断上升,以及利用抗菌材料与部分致命和高度传染性疾病作斗争,这项研究与社会特别相关。
英文摘要
By precisely tuning the surface parameters topography and chemistry using laser interference surface structuring, model surfaces on the scale of bacteria have been generated during the first proposal. Using these, the surface parameters that govern wetting, ion release and bacterial adhesion on metallic surfaces have been evaluated. In addition, the oxidation behavior of copper during viability tests with bacteria as well as the combination of copper and silver by laser cladding have been implemented and investigated on. The tuned material and surface parameters have been precisely correlated to the antimicrobial efficiency of these surfaces.The here described follow-up proposal is motivated by the partially surprising results from the first proposal. The emphasis here lies on the role of the immediate contact between material and bacteria as well as the electrochemical influence of differentiating surface potentials on the contact killing. As it has been quantitatively shown during the first proposal, that the contact between bacteria and metallic surface significantly governs the killing rate, topographically tailored copper surfaces will be created in the follow-up proposal. On these, it will be subject of investigation if and how the killing rate can be influenced by variation of the effective contact area. In the second part of the project, chemical surface pattern with controlled potential differences will be induced by laser interference lithography and consecutive metal coating. By using these patterned surfaces, the influence of potential differences will be studied by variation of material combination and pattern scale. In order to correlate it with antimicrobial efficiency, the bacterial adhesion on the investigated surfaces will be quantitatively characterized by microscope, parallel to these studies. This research is specifically relevant for the society in the light of rising antibiotics resistance of dangerous germs and the fight of partly deadly and highly infectious diseases by employing antimicrobial materials.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1128/aem.03608-12
发表时间:
2013-04-01
期刊:
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
影响因子:
4.4
作者:
[Mathews, Salima, Hans, Michael, Solioz, Marc]
通讯作者:
Solioz, Marc
Imaging Structural Damage of Bacteria on Antibacterial Copper – a Scanning Electron Microscopy Study Using FIB Cross-Sectioning
使用 FIB 横截面对细菌对抗菌铜的结构损伤进行成像 - 扫描电子显微镜研究
DOI:
10.3139/147.110339
发表时间:
2015
期刊:
Practical Metallography
影响因子:
--
作者:
[M. Hans, A.L. Rojan, F. Mücklich]
通讯作者:
F. Mücklich
DOI:
10.1016/j.apsusc.2012.09.071
发表时间:
2012-12-15
期刊:
APPLIED SURFACE SCIENCE
影响因子:
6.7
作者:
[Hans, M., Mueller, F., Muecklich, F.]
通讯作者:
Muecklich, F.
Combining advanced carbon nanoparticle coatings and laser textured surfaces for enhanced lubricity
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批准号:421441515
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项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Professor Dr.-Ing. Frank Mücklich
-
依托单位:
Synthesis and tribological investigation of carbon nanotube, onion-like carbon and nanodiamond reinforced nickel matrix composites
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批准号:265592949
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项目类别:Research Grants
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资助金额:$0.0万
-
财政年份:2014
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负责人:Professor Dr.-Ing. Frank Mücklich
-
依托单位:
Study of run-in behaviour of laser-patterned surfaces underdry sliding conditions
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批准号:233779427
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项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:2013
-
负责人:Professor Dr.-Ing. Frank Mücklich
-
依托单位:
Short-Duration Financial Aid for Major Instrument (Atom Probe Tomography - Saarland University)
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批准号:231495704
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项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:2012
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Funktionelle Oberflächen und Toxizitätsfaktoren
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批准号:191445342
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2011
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负责人:Professor Dr.-Ing. Frank Mücklich
-
依托单位:
In situ fabrication of aluminide coatings and rapid prototyping by laser cladding
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批准号:213935035
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2011
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负责人:Professor Dr.-Ing. Frank Mücklich
-
依托单位:
Study on the detailed micro-structural characteristics of Laser Cladding in terms of porosity distribution, dilution of alloying elements and stresses in the laser melted zone using focused ion beam tomography
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批准号:165626081
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2010
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Advanced design of micro/nano architectures using laser interference metallurgy
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批准号:66577916
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2008
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
EBSD-Orientierungsmessungen an magnetischen Oxid-Schichten und Bulkproben
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批准号:33954561
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2007
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Punktdefektstruktur und intrinsisches Diffusionsverhalten der B2 intermetallischen Phase RuAl und Konsequenzen für Oxidation und mechanische Eigenschaften
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批准号:5433584
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2005
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Investigation of microstructure and growth process of melt-textured YBa2Cu3O7-delta high-Tc superconductors by means of high-resolution EBSD measurements
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批准号:5412732
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2003
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Orientierungsabbildende Mikroskopie (EBSD) an nicht-leitenden Keramiken
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批准号:5261196
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2000
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Herstellung und Charakterisierung von Gradientenwerkstoffen aus Precursorpulvern mit definiertem Gradierungseffekt durch vibrationsinduzierte Pulversegregation
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批准号:5092262
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项目类别:Priority Programmes
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资助金额:$0.0万
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财政年份:1998
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Untersuchung und Optimierung der elektrischen und mechanischen Eigenschaften von Beta-Aluminat-Keramiken
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批准号:5235928
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项目类别:Priority Programmes
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资助金额:$0.0万
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财政年份:1995
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
Simulation and experimental investigation of the reaction behavior of morphologically modified reactive multilayers
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批准号:426339194
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:--
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负责人:Professor Dr.-Ing. Frank Mücklich
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依托单位:
海外基金