AccelNet-Implementation: International Biomanufacturing Network (IBioNe)

AccelNet-实施：国际生物制造网络 (IBioNe)

• 批准号: 2114716
• 负责人: Michael Betenbaugh
• 金额: $ 200万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2114716&HistoricalAwards=false
• 关键词: AccelNet; Implementation; International; Biomanufacturing; Network

Health care costs continue to rise, limiting the availability of potentially lifesaving medicines. Technology innovation in biomanufacturing represents one of the best options to both lower costs of medicines and vaccines and to save time in getting these treatments to market. However, a major bottleneck is the lack of partnerships between the U.S. and our international allies, which stymies innovation and forces each region to reinvent key manufacturing technologies. This implementation track project addresses the global challenge to coordinate, organize, and facilitate research and technological advances in biomanufacturing. The International Biomanufacturing Network (IBioNe) will link 14 networks including NSF-funded centers, Advanced Mammalian Biomanufacturing Innovation Center and Membrane Science Engineering & Technology Center, and partner organizations in Canada, Mexico, Portugal, South Korea, Japan, United Kingdom, Ireland, Austria, Australia, and Africa. By adding to the collective knowledge base and educating the next generation of biomanufacturing experts, IBioNe will accelerate discoveries and developments to make lifesaving drugs and vaccines available for the patients and public that need them.With a wealth of biological information emerging from revolutions in ‘omics, sensors, and systems and synthetic biology, a multitude of opportunities exist to build a stronger, more connected international community dedicated to advancing biomanufacturing excellence. IBioNE will serve as a catalyst for technology innovation in biomanufacturing by bringing together researchers across the ecosystem to improve biologic drugs manufacturing capabilities. Project goals are to: 1) understand the biology of biomanufacturing systems and compile omics datasets and models, 2) create references and standards for relevant cell lines, media, and platforms, 3) implement innovations in production, analytics, and control and 4) educate the future innovators and workforce leaders. With established standards, innovation will proceed rapidly across therapeutic modalities by comparing new technologies against a known reference to speed breakthroughs. IBioNe will expand websites that enable users to deposit genomes, transcriptomes, proteomes and other omics datasets and host mathematical models including those based on machine learning and artificial intelligence. Knowledge exchanges will be fostered through collaborative laboratory, conference, and workshop experiences. By creating and exchanging standards, models, expansive datasets, and expertise, IBioNe will accelerate discovery, development, and implementation of time- and cost-saving bioproduction methodologies by academic, industrial and government researchers across the globe.The Accelerating Research through International Network-to-Network Collaborations (AccelNet) program is designed to accelerate the process of scientific discovery and prepare the next generation of U.S. researchers for multiteam international collaborations. The AccelNet program supports strategic linkages among U.S. research networks and complementary networks abroad that will leverage research and educational resources to tackle grand scientific challenges that require significant coordinated international efforts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

医疗保健费用继续上升，限制了可能挽救生命的药物的供应。 生物制造的技术创新是降低药品和疫苗成本并节省将这些治疗推向市场的时间的最佳选择之一。 然而，一个主要的瓶颈是美国和我们的国际盟友之间缺乏伙伴关系，这阻碍了创新，迫使每个地区重新发明关键的制造技术。 该实施跟踪项目解决了协调，组织和促进生物制造研究和技术进步的全球挑战。 国际生物制造网络（IBioNe）将连接14个网络，包括NSF资助的中心，高级哺乳动物生物制造创新中心和膜科学工程技术中心，以及加拿大，墨西哥，葡萄牙，韩国，日本，英国，爱尔兰，奥地利，澳大利亚和非洲的合作伙伴组织。 通过增加集体知识基础和教育下一代生物制造专家，IBioNe将加速发现和开发，为需要的患者和公众提供救生药物和疫苗。随着大量生物信息从组学，传感器，系统和合成生物学的革命中涌现出来，存在大量机会来建立一个更强大，致力于推动生物制造卓越的更紧密的国际社会。 IBioNE将作为生物制造技术创新的催化剂，将整个生态系统的研究人员聚集在一起，以提高生物药物的制造能力。 项目目标是：1）了解生物制造系统的生物学并编译组学数据集和模型，2）为相关细胞系，培养基和平台创建参考和标准，3）实施生产，分析和控制创新，4）教育未来的创新者和劳动力领导者。 有了既定的标准，创新将通过将新技术与已知的参考进行比较来快速突破，从而在治疗方式上迅速进行。 IBioNe将扩展网站，使用户能够存款基因组、转录组、蛋白质组和其他组学数据集，并托管数学模型，包括基于机器学习和人工智能的模型。 将通过合作实验室、会议和讲习班经验促进知识交流。 通过创建和交换标准，模型，广泛的数据集和专业知识，IBioNe将加速发现，开发和实施节省时间和成本的生物生产方法，通过国际网络对网络合作加速研究该计划旨在加速科学发现的进程，并为下一代美国研究人员进行多团队国际合作做好准备。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。