MRI: Acquisition of a High-Resolution Accurate-Mass Orbitrap LC-MS System at Montclair State University

该奖项由主要研究仪器项目和化学研究仪器项目支持。蒙特克莱尔州立大学正在为支持高金山博士及其同事吴美银、Nina Goodey、杨邓和David Rotella购买配备Orbitrap分析仪的台式高分辨率高精度超高压液相色谱串联质谱仪(UPLC-MS/MS)系统。通常，质谱仪是用于鉴定和表征复杂样品中少量化学物种的关键分析方法之一。带有液体色谱仪的仪器通过在混合物到达质谱计之前将其分离来提供额外的结构鉴定能力。串联功能将两台质谱仪连接在一起，提高了质谱仪分析化学样品的能力。此次收购加强了这个拉美裔服务机构和地区的研究基础设施。该仪器通过让不同的学生参与到这一现代分析技术中来扩大参与。它也被新泽西理工学院、费尔利-迪金森大学和罗格斯大学的合作者使用。UPLC-MS/MS(超高性能液相色谱/二维质谱)系统的获奖旨在加强所有级别的研究和教育。它特别适用于定量和表征多糖、蛋白质和糖蛋白，以及鉴定多环芳烃、氰化毒素、脂类和生物聚合物。该仪器还用于表征潜在的候选药物及其代谢物，并用于鉴定和量化水和废水中新出现的污染物及其转化产物。该仪器还为研究人员鉴定药物物质和其他产品中的遗传毒性杂质提供服务。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Montclair State University is acquiring a benchtop high-resolution accurate-mass ultrahigh-pressure liquid chromatograph tandem mass spectrometry (UPLC-MS/MS) system with an orbitrap analyzer to support Dr. Jinshan Gao and colleagues Meiyin Wu, Nina Goodey, Yang Deng and David Rotella. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. The tandem capabilities, which couples together two mass analyzers, increase the ability of the mass spectrometer to analyze chemical samples. The acquisition strengthens the research infrastructure at this Hispanic Serving Institution and regional area. The instrument broadens participation by involving diverse students with this modern analytical technique. It is also used by collaborators at the New Jersey Institute of Technology, Fairleigh Dickinson University and Rutgers University.The award of the UPLC-MS/MS (Ultra-high performance liquid chromatography/two dimensional mass spectrometry) system is aimed at enhancing research and education at all levels. It is especially useful for quantifying and characterizing glycan, proteins and glycoproteins as well as identifying polycyclic aromatic hydrocarbons, cyanotoxin, lipids and biopolymers. The instrumentation is also used for characterizing potential drug candidates and their metabolites and for the identification of and quantification of emerging contaminants and their transformation products in water and wastewater. The instrument also serves researchers characterizing genotoxic impurities in drug substances and other products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.