MRI: Acquisition of a High-Resolution Accurate-Mass Orbitrap LC-MS System at Montclair State University

MRI：在蒙特克莱尔州立大学购置高分辨率精确质量 Orbitrap LC-MS 系统

• 批准号: 2116596
• 负责人: Jinshan Gao
• 金额: $ 45万
• 依托单位: Montclair State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2116596&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Accurate; Mass

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Montclair State University is acquiring a benchtop high-resolution accurate-mass ultrahigh-pressure liquid chromatograph tandem mass spectrometry (UPLC-MS/MS) system with an orbitrap analyzer to support Dr. Jinshan Gao and colleagues Meiyin Wu, Nina Goodey, Yang Deng and David Rotella. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. The tandem capabilities, which couples together two mass analyzers, increase the ability of the mass spectrometer to analyze chemical samples. The acquisition strengthens the research infrastructure at this Hispanic Serving Institution and regional area. The instrument broadens participation by involving diverse students with this modern analytical technique. It is also used by collaborators at the New Jersey Institute of Technology, Fairleigh Dickinson University and Rutgers University.The award of the UPLC-MS/MS (Ultra-high performance liquid chromatography/two dimensional mass spectrometry) system is aimed at enhancing research and education at all levels. It is especially useful for quantifying and characterizing glycan, proteins and glycoproteins as well as identifying polycyclic aromatic hydrocarbons, cyanotoxin, lipids and biopolymers. The instrumentation is also used for characterizing potential drug candidates and their metabolites and for the identification of and quantification of emerging contaminants and their transformation products in water and wastewater. The instrument also serves researchers characterizing genotoxic impurities in drug substances and other products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。蒙特克莱尔州立大学正在购买一个台式高分辨率精确质量超高压液相色谱串联质谱（UPLC-MS/MS）系统，该系统配有轨道阱分析仪，以支持金山高博士及其同事吴梅音、尼娜·古迪、邓扬和大卫罗泰拉。一般来说，质谱（MS）是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。 带有液相色谱仪的仪器通过在化合物到达质谱仪之前分离化合物的混合物来提供额外的结构鉴定能力。将两个质量分析仪耦合在一起的串联能力提高了质谱仪分析化学样品的能力。此次收购加强了这个西班牙裔服务机构和区域的研究基础设施。该仪器通过让不同的学生参与这种现代分析技术来扩大参与。该系统还被新泽西理工学院、费尔利·迪金森大学和罗格斯大学的合作者使用。UPLC-MS/MS（超高效液相色谱/二维质谱）系统的获奖旨在加强各级的研究和教育。它特别适用于聚糖、蛋白质和糖蛋白的定量和表征，以及多环芳烃、蓝藻毒素、脂质和生物聚合物的鉴定。 该仪器还用于表征潜在的候选药物及其代谢物，并用于鉴定和量化水和废水中的新污染物及其转化产物。该仪器还为研究人员提供药物和其他产品中遗传毒性杂质的表征服务。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Cyclic sulfones from double conjugate addition of Rongalite

• DOI: 10.1080/00397911.2023.2222316
• 发表时间: 2023-06
• 期刊: Synthetic Communications
• 影响因子: 2.1
• 作者: Melina Goga;Haonan Zong;Jazmine Prana;Rudolph Michel;Antonia Muro;Elana Rubin;Janet Brenya;M. Bebbington