MRI: Acquisition of a High Resolution Mass Spectrometer for Education and Research

MRI：购买高分辨率质谱仪用于教育和研究

• 批准号: 2117256
• 负责人: Kenyon Evans-Nguyen
• 金额: $ 36万
• 依托单位: University of Tampa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117256&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Mass; Spectrometer

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Tampa is acquiring a high resolution mass spectrometer equipped with an orbitrap analyzer, a direct analysis in real time (DART) interface and an ultrahigh pressure liquid chromatography (UPLC) unit to support Kenyon Evans-Nguyen and colleagues Kelly Deister, Michelle Crosby and Christine Theodore. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. An instrument with a high resolution liquid chromatography sector provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. The direct analysis in real time is an ion source that produces electronically or vibronically excited-state species such as helium, argon or nitrogen that ionize atmospheric molecules which then undergo ion-molecule reactions with the sample molecules to be analyzed. The instrument broadens participation by involving diverse students with this modern analytical technique. It is extensively used to train undergraduate and high school students and by collaborators at neighboring institutions.The award of the UPLC-MS/MS system is aimed at enhancing research and education at all levels. It is especially useful for quantifying, characterizing compounds to develop advanced data sets to aid natural products research. The instrumentation is also used for characterizing the spatial and temporal distributions of contaminants in Tampa Bay. The instrument also serves researchers characterizing and analyzing new psychoactive substances (NPS), also known as substances of abuse, in biological specimens. An important use is for the development and construction of ambient ionization sources capable of combined molecular, organic, and elemental analysis for applications in forensic science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。坦帕大学正在购买一台高分辨率质谱仪，配备轨道分析仪、实时直接分析（DART）接口和超高压液相色谱（UPLC）单元，以支持Kenyon Evans-Nguyen及其同事Kelly Deister、Michelle Crosby和Christine Theodore。一般来说，质谱（MS）是用于鉴定和表征复杂样品中少量化学物质的关键分析方法之一。具有高分辨率液相色谱部分的仪器通过在混合物到达质谱仪之前将其分离来提供额外的结构识别能力。实时直接分析是一种离子源，它产生电子或振动激发态物质，如氦、氩或氮，使大气分子电离，然后与待分析的样品分子发生离子-分子反应。该仪器通过让不同的学生使用这种现代分析技术来扩大参与。它被广泛用于培训本科生和高中生，并被邻近机构的合作者使用。授予UPLC-MS/MS系统的目的是加强各级的研究和教育。它对于量化、表征化合物以开发先进的数据集以帮助天然产物研究特别有用。该仪器还用于表征坦帕湾污染物的时空分布。该仪器还为研究人员在生物标本中描述和分析新的精神活性物质（NPS），也称为滥用物质。一个重要的用途是开发和构建能够结合分子、有机和元素分析的环境电离源，用于法医科学。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。