I-Corps: Ultra-Low-Cost Mechanical Ventilator for COVID-19 and Other Respiratory Applications

I-Corps：用于 COVID-19 和其他呼吸应用的超低成本机械呼吸机

• 批准号: 2123506
• 负责人: Kevin Wood
• 金额: $ 5万
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2123506&HistoricalAwards=false
• 关键词: Corps; Ultra; Low; Cost; Mechanical

The broader impact/commercial potential of this I-Corps project is the development of an ultra-low-cost intensive care unit (ICU) ventilator to provide critical care to underserved areas around the world. COVID-19 put a strain on the world’s medical supply and exposed the inadequate ventilator stockpile and manufacturing supply chain. The proposed technology is designed to meet the growing demands of hospitals in several markets, ranging from county health and human services to local hospitals in developing nations. In addition, the proposed technology may enable manufacturing and repair within local regions of the developing world. As a result, there may be two benefits to underserved areas: an increase in accessibility to medical care and an increase in local medical device production. This I-Corps project is based on the development of an ultra-low-cost intensive care unit (ICU) ventilator. This development has been made possible by combining three mechanical ventilation approaches: a mechanically driven breathing circuit, a mechanically controlled positive end-expiratory pressure (PEEP) valve, and a predictive patient feedback algorithm that provides doctors with real-time patient information utilizing only five pressure sensors. These three technologies are designed to create a cost reduction while still enabling a high degree of life-saving care for the ICU or surgical setting. Initial prototypes have been tested by physicians and respiratory therapists and have provided input for the user interface to reduce the complexity associated with user training. In addition, this proposed device has been developed with components that may be sourced locally for long-term sustainability.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响/商业潜力是开发一种超低成本的重症监护病房（ICU）呼吸机，为世界各地服务不足的地区提供重症监护。COVID-19给全球医疗供应带来压力，并暴露出呼吸机库存和制造供应链不足。该技术旨在满足多个市场医院日益增长的需求，从县卫生和人类服务到发展中国家的当地医院。 此外，拟议的技术可能使制造和维修在发展中国家的地方地区。因此，对服务不足的地区可能有两个好处：增加医疗保健的可及性和增加当地医疗器械的生产。这个I-Corps项目是基于超低成本重症监护病房（ICU）呼吸机的开发。通过结合三种机械通气方法，这种发展已经成为可能：机械驱动的呼吸回路，机械控制的呼气末正压（PEEP）阀，以及预测患者反馈算法，该算法仅利用五个压力传感器为医生提供实时患者信息。这三项技术旨在降低成本，同时仍能为ICU或手术环境提供高度的救生护理。医生和呼吸治疗师已经对初始原型进行了测试，并为用户界面提供了输入，以降低与用户培训相关的复杂性。此外，该提议的设备已经开发了可用于长期可持续性的本地采购组件。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。