OCE-PRF- Deleterious mutational load in climate driven marine range expansions

OCE-PRF-气候驱动的海洋范围扩张中的有害突变负荷

基本信息

  • 批准号:
    2127466
  • 负责人:
  • 金额:
    $ 30.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-11-01 至 2024-10-31
  • 项目状态:
    已结题

项目摘要

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).Species range expansions are occurring across the globe at unprecedented rates as global warming continues to accelerate, and even more so in marine species. In general, range expansions occur by a series of colonization events in waves of a few dispersed individuals at a time. This leads to the establishment of a new population that originates from few individuals, resulting in a small non-random representation of the genetic variation from the original population – a process known as founder effect. As a result of founder effects, a deleterious mutation that arises at the range edge disperses to a newly expanded habitat and can rapidly increase in frequency within the new population (i.e., expansion load), leading to a loss in fitness. This process is enhanced during range expansion due to the small population sizes and low genetic variation present to select against the new mutation. Fishing triggers similar evolutionary dynamics of population declines and lower genetic diversity, similarly increasing expansion loads. Marine species experience faster range expansions than terrestrial species due to their high dispersal ability and are heavily impacted by fishing pressure, yet, the interaction of both these processes have yet to be elucidated in a marine species. Quantifying the load of deleterious mutations is critical for conservation and management, because they can limit a population’s adaptability and survival. With climate change expected to continue, more species will experience range-shifts at unprecedented rates, making it imperative to document current genetic diversity and understand the genetic basis of populations at the forefront of their expanded range. This project will fund the early career development of an NSF Ocean Sciences Postdoctoral Fellow and will support the research, training, mentorship, and professional development of the fellow. To enhance the broader impacts and utility of this work, the fellow will disseminate results to the scientific community, the local fishing community and fishery management officials (e.g., NOAA, Manomet, Atlantic States Marine Fisheries Commission). Additionally, this project will increase participation of traditionally underrepresented groups in science through: (1) undergraduate student mentorship, (2) outreach seminars for students in local community colleges, and (3) outreach with the local community.The rapid accumulation of genetic mutations – and in particular deleterious mutations in edge populations – remains largely understudied during range expansions. This study presents a unique opportunity to test the evolutionary theory of the accumulation of deleterious mutations in a rapid climate-driven range expansion and harvested marine fish, Black Sea Bass (Centropristis striata). Using a combination of genome-wide data, fitness tests, and quantitative modeling approaches, the following hypotheses will be tested: H1- (Higher load at range edge) C. striata will show a greater expansion load in coding regions at the range expansion front compared to the historical range center and edge populations; H2- (Decreased fitness at range edge) range expanding populations with a greater expansion load will show evidence of decreased fitness-related traits; H3- (Load exacerbated by fishing) overfishing will exacerbate the accumulation of deleterious mutational load in expanding populations. If results support the hypotheses (i.e., higher loads and decreased fitness are found at the expanding-front), as predicted by theory, they will have widespread implications for marine conservation strategies in a rapidly changing climate. However, if these hypotheses are rejected, the data will challenge existing scientific assumptions, suggesting marine systems undergo different processes. This integrative dataset will advance understanding of climate-driven range expansions and the interactive effects of climate change and fishing pressure on marine species, such as Black Sea Bass.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该奖项全部或部分由2021年美国救援计划法案(公法117-2)资助。随着全球变暖继续加速,物种范围正在以前所未有的速度在地球仪范围内扩大,海洋物种更是如此。一般来说,分布范围的扩大是通过一系列的殖民化事件发生的,每次有几个分散的个体。这导致了一个新的群体的建立,该群体起源于几个个体,导致了来自原始群体的遗传变异的小的非随机表示-一个被称为创始人效应的过程。作为创始人效应的结果,在范围边缘出现的有害突变分散到新扩展的栖息地,并且可以在新种群中迅速增加频率(即,膨胀负荷),导致健身损失。这个过程在范围扩展期间由于小的群体大小和低的遗传变异而增强,以针对新的突变进行选择。捕鱼引发了类似的种群下降和遗传多样性降低的进化动态,同样增加了扩张负荷。海洋物种由于其高度的扩散能力而比陆地物种经历更快的范围扩张,并受到捕捞压力的严重影响,然而,这两个过程的相互作用在海洋物种中尚未得到阐明。量化有害突变的负荷对于保护和管理至关重要,因为它们会限制种群的适应性和生存。随着气候变化预计将继续,更多的物种将以前所未有的速度经历范围转移,因此必须记录当前的遗传多样性,并了解处于扩大范围最前沿的种群的遗传基础。该项目将资助NSF海洋科学博士后研究员的早期职业发展,并将支持研究,培训,指导和研究员的专业发展。为了加强这项工作的广泛影响和效用,研究员将向科学界、当地渔业界和渔业管理官员(例如,NOAA、Manomet、大西洋国家海洋渔业委员会)。此外,该项目将通过以下方式增加传统上代表性不足的群体对科学的参与:(1)本科生导师制,(2)为当地社区学院的学生举办外联研讨会,(3)与当地社区开展外联活动。基因突变的快速积累--特别是边缘群体中的有害突变--在分布范围扩大期间,在很大程度上仍然没有得到充分研究。这项研究提供了一个独特的机会,以测试有害突变在快速气候驱动的范围扩张和收获的海鱼,黑海鲈鱼(Centropristis striata)积累的进化理论。使用全基因组数据、适应性检验和定量建模方法的组合,将检验以下假设:H1-(范围边缘的较高负荷)C。与历史分布区中心和边缘种群相比,striata在分布区扩展前沿的编码区中显示出更大的扩展负荷;具有更大扩展负荷的H2-(分布区边缘适应度降低)分布区扩展种群将显示出适应度相关性状降低的证据; H3-(捕捞加剧的负荷)过度捕捞将加剧扩展种群中有害突变负荷的积累。如果结果支持假设(即,如理论所预测的那样,它们将对迅速变化的气候中的海洋养护战略产生广泛的影响。然而,如果这些假设被拒绝,数据将挑战现有的科学假设,表明海洋系统经历不同的过程。这一综合数据集将促进对气候驱动的范围扩张以及气候变化和捕捞压力对海洋物种(如黑海鲈鱼)的相互影响的理解。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

项目成果

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Remy Gatins其他文献

Fine-scale population structure of two anemones (Stichodactyla gigantea and Heteractis magnifica) in Kimbe Bay, Papua New Guinea
巴布亚新几内亚金贝湾两种海葵(Stichodactyla gigantea 和 Heteractis magnifica)的精细种群结构
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Remy Gatins;P. Saenz‐Agudelo;A. Scott;M. Berumen
  • 通讯作者:
    M. Berumen
COMPARATIVE PHYLOGEOGRAPHY OF THREE HOST SEA ANEMONES
三种寄主海葵的比较系统地理学
  • DOI:
    10.1101/2023.11.23.568484
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Madeleine A. Emms;P. Saenz‐Agudelo;E. Giles;Remy Gatins;G. Nanninga;A. Scott;A. Frisch;S. Mills;R. Beldade;M. Berumen
  • 通讯作者:
    M. Berumen

Remy Gatins的其他文献

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