Polydentate Lewis acids with oriented acceptor functions
具有定向受体功能的多齿路易斯酸
基本信息
- 批准号:248859450
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2013
- 资助国家:德国
- 起止时间:2012-12-31 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Tailor-made structuring of molecular matter allows realizing specific chemical reactivity. Nature demonstrates in manifold ways how concerted spatial placement of reactive functions leads to specific reactivity (usually donor functions or hydrogen bridges). This is also frequently used in synthesis and in the construction of catalysts and receptors. In contrast to the donor functions used in this context (ligand design) examples with defined placement and orientation of acceptor functions (Lewis acids) are still scarce. However, such a concept would enable us to recognize anions and Lewis bases and consequently allow modifying their properties and reactivities. The aim of this project is therefore to place multiple Lewis-acid functions at suitable molecular scaffolds in a defined and oriented way for an optimized binding of Lewis basic substrates. The challenges were so far the very limited accessibility of suitable molecular scaffolds for attaching such functions. They have to be free of Lewis basic units; otherwise they would compete with the substrates for the acidic functions. In the first project period we have developed efficient access to rigid backbone molecules on the basis of hydrocarbons or organosilane scaffold molecules. These include 1,8-functionalized anthracenes, photochemically accessible anthracene dimers with four concordantly oriented functions, photochemically ‘dimerizable’ bridged bis(anthracenes) with switchable selectivities as well as triptycene with three concordantly oriented functions. In addition we found a very elegant synthesis of a syn-anthracen dimer with four alkyne functions pointing into one direction, whose high selectivity is the result of a hydrogen-bridged pre-complex during dimerization. Consequently, it is now clear which of the numerous tested systems provide practicable pathways for the multi-step syntheses to multidentate Lewis-acids, in order to give access to substantial amounts for further experiments aiming at their applications. We have demonstrated for several examples how to attach acceptor functions to these scaffolds. These functions are organometallic units of the elements Al, Ga and In (also Zn and Hg) and electronegatively substituted non-metallic functions of boron and silicon as well as gold functions binding via d10-d10 interactions. In the second project period we intend to bring in the harvest of the work and investment of the first period. We will prepare a variety of new multidentate Lewis-acids and study their chemical properties. These include possibilities of molecular recognition and complexing properties, the ability to enhance the acidity of Lewis acids by complexation with multidentate acceptors (aim ‘super Lewis-acids’), the generation of unusual complexes by chelating dispersive-type interactions, and the use of multidentate Lewis-acids in frustrated Lewis-pair chemistry.
Tailor-made structuring of molecular matter allows realizing specific chemical reactivity. Nature demonstrates in manifold ways how concerted spatial placement of reactive functions leads to specific reactivity (usually donor functions or hydrogen bridges). This is also frequently used in synthesis and in the construction of catalysts and receptors. In contrast to the donor functions used in this context (ligand design) examples with defined placement and orientation of acceptor functions (Lewis acids) are still scarce. However, such a concept would enable us to recognize anions and Lewis bases and consequently allow modifying their properties and reactivities. The aim of this project is therefore to place multiple Lewis-acid functions at suitable molecular scaffolds in a defined and oriented way for an optimized binding of Lewis basic substrates. The challenges were so far the very limited accessibility of suitable molecular scaffolds for attaching such functions. They have to be free of Lewis basic units; otherwise they would compete with the substrates for the acidic functions. In the first project period we have developed efficient access to rigid backbone molecules on the basis of hydrocarbons or organosilane scaffold molecules. These include 1,8-functionalized anthracenes, photochemically accessible anthracene dimers with four concordantly oriented functions, photochemically ‘dimerizable’ bridged bis(anthracenes) with switchable selectivities as well as triptycene with three concordantly oriented functions. In addition we found a very elegant synthesis of a syn-anthracen dimer with four alkyne functions pointing into one direction, whose high selectivity is the result of a hydrogen-bridged pre-complex during dimerization. Consequently, it is now clear which of the numerous tested systems provide practicable pathways for the multi-step syntheses to multidentate Lewis-acids, in order to give access to substantial amounts for further experiments aiming at their applications. We have demonstrated for several examples how to attach acceptor functions to these scaffolds. These functions are organometallic units of the elements Al, Ga and In (also Zn and Hg) and electronegatively substituted non-metallic functions of boron and silicon as well as gold functions binding via d10-d10 interactions. In the second project period we intend to bring in the harvest of the work and investment of the first period. We will prepare a variety of new multidentate Lewis-acids and study their chemical properties. These include possibilities of molecular recognition and complexing properties, the ability to enhance the acidity of Lewis acids by complexation with multidentate acceptors (aim ‘super Lewis-acids’), the generation of unusual complexes by chelating dispersive-type interactions, and the use of multidentate Lewis-acids in frustrated Lewis-pair chemistry.
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Syntheses and Structures of 1,8,13,16-Substituted Triptycenes
1,8,13,16-取代三蝶烯的合成和结构
- DOI:10.1002/ejoc.201800770
- 发表时间:2018
- 期刊:
- 影响因子:2.8
- 作者:A. Schwartzen;M. Rovers;B. Neumann;H.-G. Stammler;N. W. Mitzel
- 通讯作者:N. W. Mitzel
A Rational Approach to Tetra‐Functional Photo‐Switches
- DOI:10.1002/open.201900029
- 发表时间:2019-03
- 期刊:
- 影响因子:2.3
- 作者:Philipp Niermeier;Jan-Hendrik Lamm;A. Mix;B. Neumann;H. Stammler;N. Mitzel
- 通讯作者:Philipp Niermeier;Jan-Hendrik Lamm;A. Mix;B. Neumann;H. Stammler;N. Mitzel
Syntheses, Solid State Structures and Photochemistry of α,ω-Bis-[(1,8-dichloroanthracen-10-yl)dimethylsilyl]alkanes
α,β-双-[(1,8-二氯蒽-10-基)二甲基甲硅烷基]烷烃的合成、固态结构和光化学
- DOI:10.1055/s-0037-1610128
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:P. Niermeier;J.-H. Lamm;M. Linnemannstöns;B. Neumann;H.-G. Stammler;N. W. Mitzel
- 通讯作者:N. W. Mitzel
Zweizähnige Bor-Lewis-Säuren und ihre Selektivität in der Wirt-Gast-Komplexbildung
双齿硼路易斯酸及其在主客体络合物形成中的选择性
- DOI:10.1002/anie.201812696
- 发表时间:1969
- 期刊:
- 影响因子:0
- 作者:P. Niermeier;S. Blomeyer;Y. K. J. Bejaoui;J. L. Beckmann;B. Neumann;H.-G. Stammler;N. W. Mitzel
- 通讯作者:N. W. Mitzel
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Professor Dr. Norbert W. Mitzel其他文献
Professor Dr. Norbert W. Mitzel的其他文献
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{{ truncateString('Professor Dr. Norbert W. Mitzel', 18)}}的其他基金
Polydentate Lewis Acid Acceptor Bowls and Chalices
多齿路易斯酸受体碗和圣杯
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424957011 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Research Grants
Structure Determination of Di-tert-butyldiphosphatetrahedrane in the Solid and Gas Phases
二叔丁基二磷酸四面体固相和气相的结构测定
- 批准号:
434445823 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Research Grants
Core Facility Gas Electron Diffraction and Small Molecule Structures Centre, Bielefeld (GED@BI)
核心设施气体电子衍射和小分子结构中心,比勒费尔德 (GED@BI)
- 批准号:
324757882 - 财政年份:2017
- 资助金额:
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Core Facilities
Multiply Lewis-acidic and metallophilic receptor systems with trisilacyclohexane skeletons
将路易斯酸性和亲金属受体系统与三硅杂环己烷骨架相乘
- 批准号:
313483887 - 财政年份:2016
- 资助金额:
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Research Grants
Frustrated Lewis-Pairs with Silicon, Germanium and Tin as Lewis-acidic Functions
受挫路易斯对与硅、锗和锡作为路易斯酸性官能团
- 批准号:
320753677 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Research Grants
Czech-German Cooperation Project: Structure studies on inner and outer functionalized icosahedral and bicapped square-antiprismatic boron clusters
捷德合作项目:内外功能化二十面体和双帽方反棱柱硼团簇的结构研究
- 批准号:
234021884 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Research Grants
Gas Electron Diffraction and Small Molecule Structures Centre, Bielefeld (GED@BI)
气体电子衍射和小分子结构中心,比勒费尔德 (GED@BI)
- 批准号:
233477935 - 财政年份:2013
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Core Facilities
Small chalcogen-organyls - fundamental structural, conformational and electronic properties
小硫族有机基 - 基本结构、构象和电子特性
- 批准号:
179077585 - 财政年份:2010
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Research Grants
Doppelt Heteroatom-funktionalisierte Carbanionen - Synthese, Bildungsmechanismen und Anwendungen
双杂原子功能化碳负离子——合成、形成机制和应用
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104453850 - 财政年份:2009
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Electron density topology and nature of bonding in small ring compounds with dative bonds
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46157942 - 财政年份:2007
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