SBIR Phase I: Optimized Extraction and Projection Optics for Ion Point Sources
SBIR 第一阶段:优化离子点源的提取和投影光学器件
基本信息
- 批准号:2136792
- 负责人:
- 金额:$ 25.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2023-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Small Business Innovation Research Phase I project seeks to demonstrate a technology advance in the field of imaging mass spectrometry. A successful project will enable: (1) markedly improved mass resolving power sufficient to separate key mass interferences that limit the technique, and (2) introduction of a new generation of position-sensitive ion detectors to dramatically improve data acquisition rates by 100 times and detection efficiency to 100%. These developments will create an opportunity to rethink the underlying architecture of commercial stigmatic-imaging time-of-flight mass spectrometry microscopes. With this technology, a new generation of instruments will be realized. The addressable market opportunity for these instruments is currently about $50 million per annum and is expected to grow with the new superior performance and with increasing need which grows more acute with time. Such improved instruments can beneficially impact major industries such as semiconductors ($450 billlon per year) and metals ($12 trillion per year). Improvements in the quality, quantity, and availability of atomic-scale information from imaging mass spectrometry instruments thus can have a large impact on technological progress. The advances sought in this project are the first steps toward new tools that will meet the demands of scientists and engineers for decades. The intellectual merit of this project is embodied in an experimental test of a new optical approach to control beam divergence from point sources of charged particles. By controlling beam divergence, ion imaging detectors can be optimally adapted to record images with superior properties. This will significantly advance fields of stigmatic-imaging mass spectrometry and ion-beam projection instrumentation. Extensive computer simulations have been conducted and used to aid design of prototype ion optics. The ability of these optics to control the ion beam divergence while projecting stigmatic ion images must be confirmed. Such ion images will be recorded over a wide range of operating conditions of the ion source and optics. A proof-of-concept experiment is proposed here to validate predictions of modeling. The quality of the projection will be assessed and compared with the simulations for validation of the models and further optimization aiming at development of a product prototype. This work will enable 1) long-sought-after imaging time-of-flight mass spectrometry measurements with large field of view and high mass resolving power for precise ion identification, and 2) implementation of a new generation of ion detectors that offer 100% detection efficiency and a hundred-fold increase in data acquisition rate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个小型企业创新研究第一阶段项目旨在展示成像质谱学领域的技术进步。一个成功的项目将使:(1)显著提高质量分辨率,足以分离限制该技术的关键质量干扰,以及(2)引入新一代位置灵敏离子探测器,将数据采集速度大幅提高100倍,探测效率达到100%。这些发展将创造一个机会,重新思考商业污名成像飞行时间质谱学显微镜的基础架构。有了这项技术,新一代仪器将被实现。这些工具的潜在市场机会目前每年约为5,000万美元,预计将随着新的优越表现和日益增长的需求而增长,这种需求随着时间的推移而变得更加尖锐。这种改进的工具可以有益地影响半导体(每年4500亿美元)和金属(每年12万亿美元)等主要行业。因此,来自成像质谱仪的原子级信息在质量、数量和可用性方面的改进可以对技术进步产生重大影响。该项目寻求的进展是迈向新工具的第一步,这些工具将满足科学家和工程师数十年的需求。该项目的智能优势体现在对一种新的光学方法的实验测试中,该方法可以控制来自带电粒子点源的光束发散。通过控制光束发散,离子成像探测器可以最佳地适应记录具有优异性能的图像。这将大大推进色散成像质谱学和离子束投影仪器领域的发展。已经进行了大量的计算机模拟,并用于辅助原型离子光学的设计。必须确认这些光学元件在投射色散离子图像的同时控制离子束发散的能力。这样的离子图像将在离子源和光学器件的广泛操作条件下被记录。这里提出了一个概念验证实验来验证模型的预测。将对预测的质量进行评估,并与模拟进行比较,以验证模型并针对产品原型的开发进行进一步优化。这项工作将使1)大视场和高质量分辨率的大视场和高质量分辨率的成像飞行时间质谱学测量用于精确的离子识别,以及2)新一代离子探测器的实施,提供100%的探测效率和100倍的数据采集速率。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Thomas Kelly其他文献
Comparison of Three Point-of-Care Ultrasound Views and MRI Measurements for Optic Nerve Sheath Diameter: A Prospective Validity Study
- DOI:
10.1007/s12028-019-00881-7 - 发表时间:
2019-12-02 - 期刊:
- 影响因子:3.600
- 作者:
Ronak Raval;Jay Shen;Deon Lau;Nick Ferguson;Thomas Kelly;Justin Daniels;Ihab Dorotta;Davinder Ramsingh - 通讯作者:
Davinder Ramsingh
In Defense of Bias: Replies to Berker, Greco, and Johnson
- DOI:
10.1007/s11098-025-02304-0 - 发表时间:
2025-04-04 - 期刊:
- 影响因子:1.300
- 作者:
Thomas Kelly - 通讯作者:
Thomas Kelly
709-2 Primary Angioplasty for Acute Myocardial Infarction in Elderly Thrombolytic Candidates: Is It the Best Option?
- DOI:
10.1016/0735-1097(95)91651-d - 发表时间:
1995-02-01 - 期刊:
- 影响因子:
- 作者:
Thomas Stuckey;Bruce Brodie;Charles Hansen;Denise Muncy;Richard Weintraub;Thomas Kelly;Jonathan Berry;E. Joseph LeBauer - 通讯作者:
E. Joseph LeBauer
Seprase complexes in cellular invasiveness
- DOI:
10.1023/a:1023055600919 - 发表时间:
2003-06-01 - 期刊:
- 影响因子:8.700
- 作者:
Wen-Tien Chen;Thomas Kelly - 通讯作者:
Thomas Kelly
Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions
- DOI:
10.1007/s10585-011-9392-x - 发表时间:
2011-05-22 - 期刊:
- 影响因子:3.200
- 作者:
Yan Huang;Avis E. Simms;Anna Mazur;Sophie Wang;Noel R. León;Barry Jones;Nazneen Aziz;Thomas Kelly - 通讯作者:
Thomas Kelly
Thomas Kelly的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Thomas Kelly', 18)}}的其他基金
Randomness in High-Dimensional Combinatorics: Colorings, Robustness, and Statistics
高维组合中的随机性:着色、鲁棒性和统计
- 批准号:
2247078 - 财政年份:2023
- 资助金额:
$ 25.53万 - 项目类别:
Continuing Grant
OCE-PRF: The Biogeochemical Importance of Marine Particles: Connecting Production and Export in the Northern Gulf of Alaska
OCE-PRF:海洋颗粒的生物地球化学重要性:连接阿拉斯加北部湾的生产和出口
- 批准号:
2205954 - 财政年份:2022
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase I: Development of New Pulsing Mechanisms for Local Electrode Atom Probe Analyses of Electronic Materials
SBIR 第一阶段:开发用于电子材料局部电极原子探针分析的新型脉冲机制
- 批准号:
0340351 - 财政年份:2004
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase II: Three-Dimensional Atom Probe Imaging for Nano-Biotechnology
SBIR 第二阶段:用于纳米生物技术的三维原子探针成像
- 批准号:
0216620 - 财政年份:2002
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
Development of a Local Electrode Atom Probe
局部电极原子探针的研制
- 批准号:
9703932 - 财政年份:1997
- 资助金额:
$ 25.53万 - 项目类别:
Continuing Grant
Acquisition of a Field Emission Scanning Microscope with Automated Orientation
获得具有自动定向功能的场发射扫描显微镜
- 批准号:
9512579 - 财政年份:1995
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
Presidential Awards for Excellence in Science and Mathematics Teaching
科学和数学教学卓越总统奖
- 批准号:
9254548 - 财政年份:1992
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
Acquisition of High-Resolution Transmission Electron Microscope
购置高分辨率透射电子显微镜
- 批准号:
9017107 - 财政年份:1991
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
Presidential Young Investigator Award
总统青年研究员奖
- 批准号:
8451933 - 财政年份:1985
- 资助金额:
$ 25.53万 - 项目类别:
Continuing Grant
相似国自然基金
Baryogenesis, Dark Matter and Nanohertz Gravitational Waves from a Dark
Supercooled Phase Transition
- 批准号:24ZR1429700
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
ATLAS实验探测器Phase 2升级
- 批准号:11961141014
- 批准年份:2019
- 资助金额:3350 万元
- 项目类别:国际(地区)合作与交流项目
地幔含水相Phase E的温度压力稳定区域与晶体结构研究
- 批准号:41802035
- 批准年份:2018
- 资助金额:12.0 万元
- 项目类别:青年科学基金项目
基于数字增强干涉的Phase-OTDR高灵敏度定量测量技术研究
- 批准号:61675216
- 批准年份:2016
- 资助金额:60.0 万元
- 项目类别:面上项目
基于Phase-type分布的多状态系统可靠性模型研究
- 批准号:71501183
- 批准年份:2015
- 资助金额:17.4 万元
- 项目类别:青年科学基金项目
纳米(I-Phase+α-Mg)准共晶的临界半固态形成条件及生长机制
- 批准号:51201142
- 批准年份:2012
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
连续Phase-Type分布数据拟合方法及其应用研究
- 批准号:11101428
- 批准年份:2011
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
D-Phase准晶体的电子行为各向异性的研究
- 批准号:19374069
- 批准年份:1993
- 资助金额:6.4 万元
- 项目类别:面上项目
相似海外基金
SBIR Phase II: Thermally-optimized power amplifiers for next-generation telecommunication and radar
SBIR 第二阶段:用于下一代电信和雷达的热优化功率放大器
- 批准号:
2335504 - 财政年份:2024
- 资助金额:
$ 25.53万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Optimized Hydrothermal Reactor for Scalable and Affordable Destruction of Per- and Polyfluorinated Substances (PFAS)
SBIR 第二阶段:优化的水热反应器,可大规模且经济地销毁全氟和多氟物质 (PFAS)
- 批准号:
2232969 - 财政年份:2023
- 资助金额:
$ 25.53万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Power-Optimized Beamforming Front-End Technology for High-Capacity Millimeter-Wave Wireless Communications
SBIR 第二阶段:用于高容量毫米波无线通信的功率优化波束成形前端技术
- 批准号:
2243835 - 财政年份:2023
- 资助金额:
$ 25.53万 - 项目类别:
Cooperative Agreement
SBIR Phase I: A Novel SARS-CoV-2 Virus-Like Particle Optimized to Deliver shRNA Therapeutics to Prevent and Treat Infection (COVID-19)
SBIR 第一阶段:一种新型 SARS-CoV-2 病毒样颗粒,经过优化可提供 shRNA 疗法来预防和治疗感染 (COVID-19)
- 批准号:
2051972 - 财政年份:2021
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase I: Genomically Optimized Turf Grass
SBIR 第一阶段:基因组优化的草坪草
- 批准号:
2037522 - 财政年份:2021
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase I: Project PAIR: Optimized Managed Care Through Personalized AI for Individuals in Recovery
SBIR 第一阶段:PAIR 项目:通过个性化人工智能为康复中的个人优化管理式护理
- 批准号:
2025931 - 财政年份:2020
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase I: MouthLab - A Medical Tricorder Optimized for Real-time, Rapid Assessment of COVID-19 Patients And Those At Risk
SBIR 第一阶段:MouthLab - 针对实时、快速评估 COVID-19 患者和高危人群而优化的医疗三录仪
- 批准号:
2027721 - 财政年份:2020
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase I: Power-Optimized Beamforming Front-End Technology for High-Capacity Millimeter-Wave Wireless Communications
SBIR 第一阶段:用于高容量毫米波无线通信的功率优化波束成形前端技术
- 批准号:
2014942 - 财政年份:2020
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase I: Interest-Aligned College Degree Planning within an Optimized Multiplan Framework
SBIR 第一阶段:优化的多计划框架内符合兴趣的大学学位规划
- 批准号:
1647478 - 财政年份:2016
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant
SBIR Phase II: Efficacy of scaled up optimized urease producing microorganisms for manufacturing biocement binders towards a viable masonry construction material
SBIR 第二阶段:放大优化的脲酶生产微生物的功效,用于制造生物水泥粘合剂以形成可行的砖石建筑材料
- 批准号:
1534787 - 财政年份:2015
- 资助金额:
$ 25.53万 - 项目类别:
Standard Grant