OPP-PRF: Revealing the Genomic Underpinnings of Polar Bear Physiological Adaptations to the Arctic
OPP-PRF:揭示北极熊生理适应北极的基因组基础
基本信息
- 批准号:2138649
- 负责人:
- 金额:$ 30.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Study of the genomic basis and evolution of physiological adaptations can provide valuable insight on the impacts of climate change on Arctic species. This research focuses on the polar bear, an iconic symbol of climate change, and its adaptation to high-latitude environments. Multiple types of genome data from closely related bear species will be used to identify regions of the polar bear genome that underlie specific physiological adaptations. This information will improve understanding of current and future impacts of climate change on these animals. To broaden participation and diversity in Arctic science, the fellow will conduct public outreach, organize workshops, and mentor students from underrepresented groups.While brown and black bears undergo annual hibernation in response to seasonal prey scarcity, the ability to hibernate has been greatly reduced, and nearly lost altogether, in the adaptation of polar bears to the Arctic. Given the complexity of the hibernation phenotype and the short divergence time between polar bears and hibernating bear lineages, evolution of regulatory sequences may have played a particularly important role in evolution. Through the integration of functional and population genomics datasets, this project will characterize the landscape of protein coding and regulatory evolution in three bear lineages and test the hypothesis that regulatory evolution facilitated the rapid adaptation of the polar bear lineage to Arctic environments. This work will advance understanding of the mechanisms and complexity of polar bear adaptations, the processes by which polar bears adapted to Arctic environments, and the vulnerability of this apex predator to climate change. The project will also provide insights into vertebrate genomics and evolution, broadening our understanding of the processes by which complex physiological traits arise and evolve in vertebrates.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
对生理适应的基因组基础和进化的研究可以提供关于气候变化对北极物种影响的宝贵见解。这项研究的重点是北极熊,气候变化的标志性象征,以及它对高纬度环境的适应。来自密切相关的熊物种的多种类型的基因组数据将用于确定北极熊基因组中作为特定生理适应基础的区域。这些信息将有助于了解气候变化对这些动物的当前和未来影响。为了扩大北极科学的参与度和多样性,该研究员将开展公共宣传,组织研讨会,并指导来自代表性不足群体的学生。虽然棕熊和黑熊每年都要冬眠,以应对季节性猎物短缺,但冬眠的能力已经大大降低,几乎完全丧失,在北极熊适应北极的过程中。考虑到冬眠表型的复杂性以及北极熊和冬眠熊谱系之间的短分歧时间,调控序列的进化可能在进化中发挥了特别重要的作用。通过整合功能和种群基因组学数据集,该项目将描述三个熊谱系中蛋白质编码和调控进化的景观,并测试调控进化促进北极熊谱系快速适应北极环境的假设。这项工作将促进对北极熊适应机制和复杂性的理解,北极熊适应北极环境的过程,以及这种顶级捕食者对气候变化的脆弱性。该项目还将提供对脊椎动物基因组学和进化的见解,拓宽我们对脊椎动物复杂生理特征产生和进化过程的理解。该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Feeding during hibernation shifts gene expression toward active season levels in brown bears (Ursus arctos)
- DOI:10.1152/physiolgenomics.00030.2023
- 发表时间:2023-09-01
- 期刊:
- 影响因子:4.6
- 作者:Perry,Blair W.;Mcdonald,Anna L.;Kelley,Joanna L.
- 通讯作者:Kelley,Joanna L.
A Beary Good Genome: Haplotype-Resolved, Chromosome-Level Assembly of the Brown Bear (Ursus arctos).
- DOI:10.1093/gbe/evac125
- 发表时间:2022-09-06
- 期刊:
- 影响因子:3.3
- 作者:Armstrong, Ellie E.;Perry, Blair W.;Huang, Yongqing;Garimella, Kiran, V;Jansen, Heiko T.;Robbins, Charles T.;Tucker, Nathan R.;Kelley, Joanna L.
- 通讯作者:Kelley, Joanna L.
A multi-tissue gene expression dataset for hibernating brown bears.
- DOI:10.1186/s12863-023-01136-3
- 发表时间:2023-06-08
- 期刊:
- 影响因子:1.9
- 作者:
- 通讯作者:
Circadian gene transcription plays a role in cellular metabolism in hibernating brown bears, Ursus arctos
- DOI:10.1007/s00360-023-01513-5
- 发表时间:2023-10-11
- 期刊:
- 影响因子:2
- 作者:Vincent,Ellery P.;Perry,Blair W.;Jansen,Heiko T.
- 通讯作者:Jansen,Heiko T.
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