Excellence in Research: Direct synthesis of water soluble iron oxide nanoparticles with high relaxivity and interaction with small molecules

卓越的研究：直接合成具有高弛豫率和与小分子相互作用的水溶性氧化铁纳米颗粒

• 批准号: 2000135
• 负责人: Yongfeng Zhao
• 金额: $ 47.5万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2000135&HistoricalAwards=false
• 关键词: Excellence; Research; Direct; synthesis; water

Nontechnical Summary:This project investigates how magnetic resonance image (MRI) signals change as iron oxide nanoparticles interact with bioactive molecules. The understanding of such signal changes provides a scientific foundation to monitor drug delivery and release using MRI, which will significantly improve the treatment of diseases such as cancer as the dosage and frequency of drugs can be adjusted based on real-time drug uptake information. The major challenges of current approaches for monitoring drug delivery include lack of high sensitivity and limited tissue volume to be imaged. We overcome these challenges by synthesizing high water-soluble iron oxide nanoparticles and using them as MRI agents. MRI is a powerful imaging technique in clinical practice because it provides images with excellent details in a non-invasive, whole-body, and real-time monitoring manner. The multifunctional properties of nanoparticles provide unique advantages for the precise delivery of therapeutic agents with the assistance of imaging. The broad impacts of the project will be achieved by: (1) disseminating the knowledge obtained from this research to the science community for monitoring drug delivery where a non-invasive monitor is extremely important; (2) providing cutting-edge research opportunities for undergraduate and graduate students, particularly those from underrepresented students at Jackson State University (JSU); (3) promoting STEM education via exhibitions during the Mississippi Science Maker at Mississippi Museum of Nature and Science.Technical summary:Nanoparticles can improve drug efficacy and reduce toxicity by altering pharmacokinetics. To track the delivery behavior of drugs, fluorescent tags or radiotracers are usually attached. However, the intrinsic drawback of fluorescent tags lies in the limitation of tissue penetration of light. Availability is a significant challenge for radiotracer approaches. In comparison, iron oxide nanoparticles (IONPs) could be used as a self-reported drug delivery system because of their capability to change water relaxivity in tissue and their excellent biocompatibility. Despite intensive interests, the effect of bioactive molecules on the T1-weighted magnetic property of extrasmall iron oxide nanoparticles (ESIONPs) has not been studied. In addition, the T1 relaxation performance of IONPs is relatively low. The partial reason is that the monodispersal IONPs synthesized by current methods can only be dissolved in an organic solvent. A sophisticated surface modification is required to make them water soluble. In this project, a stepwise growth method will be explored to directly synthesize water soluble ESIONPs with a high T1 relaxation performance. The interaction of ESIONPs with bioactive molecules will be investigated as self-reported nano platform for drug delivery. The project will gain a fundamental understanding of T1 relaxivity of ESIONPs interacting with bioactive molecules.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要：该项目研究了磁共振图像（MRI）信号随着氧化铁纳米颗粒与生物活性分子相互作用时的变化。对此类信号变化的理解为使用MRI监测药物输送和释放的科学基础，这将显着改善诸如癌症（例如剂量和频率）的疾病治疗，可以根据实时药物吸收信息来调整药物的剂量和频率。当前监测药物输送方法的主要挑战包括缺乏高灵敏度和有限的组织体积。我们通过合成高水溶性氧化铁纳米颗粒并将其用作MRI剂来克服这些挑战。 MRI是临床实践中一种强大的成像技术，因为它以非侵入性，全身和实时监测方式提供了出色的细节图像。纳米颗粒的多功能性能为精确递送治疗剂提供了独特的优势。该项目的广泛影响将通过：（1）传播从这项研究获得的知识到科学界，以监测非侵入性监测器非常重要的药物输送； （2）为本科生和研究生提供尖端的研究机会，尤其是来自杰克逊州立大学（JSU）的代表性不足的学生的研究生； （3）密西西比州自然与科学博物馆密西西比科学制造商期间通过展览促进STEM教育。技术摘要：纳米颗粒可以通过改变药代动力学来提高药物疗效并降低毒性。为了跟踪药物的递送行为，通常附着荧光标签或放射性示例。但是，荧光标签的固有缺点在于限制光的光线。对于放射性示例方法，可用性是一个重大挑战。相比之下，氧化铁纳米颗粒（IONP）可以用作自我报告的药物输送系统，因为它们有能力改变组织中的水松弛性及其出色的生物相容性。尽管有密集的兴趣，但尚未研究生物活性分子对氧化铁纳米颗粒（ESIONP）T1加权磁性特性的影响。另外，IONP的T1松弛性能相对较低。部分原因是，通过当前方法合成的单分散性离子可以溶解在有机溶剂中。需要进行复杂的表面修饰以使它们可溶。在该项目中，将探索一种逐步增长方法，以直接合成具有高T1松弛性能的水溶性eSionp。 ESIONP与生物活性分子的相互作用将被研究为自我报告的纳米量平台，用于药物输送。该项目将对ESIONP与生物活性分子相互作用的T1放松性获得基本的理解。该奖项反映了NSF的法定使命，并且使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来提供支持。

项目成果

Size-Dependent Activity of Iron Nanoparticles in Both Thermal and Plasma Driven Catalytic Ammonia Decomposition

• DOI: 10.1021/acs.iecr.2c02092
• 发表时间: 2022-08-10
• 期刊: INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
• 影响因子: 4.2
• 作者: Chen, Genwei;Qu, Jing;Xiang, Yizhi
• 通讯作者: Xiang, Yizhi