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Rheology of biocompatible ferrofluids in blood

血液中生物相容性铁磁流体的流变学

基本信息

批准号：
250202568
负责人：
Professor Dr. Stefan Odenbach
金额：
--
依托单位：
Professur für Magnetofluiddynamik, Mess- und Automatisierungstechnik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/250202568?language=en
关键词：
Rheology biocompatible ferrofluids blood

项目摘要

The use of suspensions of magnetic particles in biomedical applications - especially in cancer therapy has attracted growing interest in the past decades. In this context basic investigations have shown, that especially the fluid mechanics aspects of an approach commonly called magnetic drug targeting, i.e. a magnetically controlled delivery towards a tumor zone, still require the clarification of numerous fundamental aspects. Of particular interest in this respect are changes of the viscous behavior of the respective suspensions in the presence of magnetic fields that are needed for the clarification of basic fluid mechanical questions. Preliminary experiments have shown that biocompatible ferrofluids show a significant increase in their viscosity accompanied by the appearance of changes in their flow behavior even in weak magnetic fields. This is forced by the fact that comparably large clusters of magnetic particles exist in such biocompatible ferrofluids exhibiting a strong magnetic moment, which gives rise to strong interparticle interaction. The preliminary investigations have moreover shown that the observed effects subsist even if the fluids are diluted with water or blood. Thus, it is the central objective of project to clarify the rheology of suspensions of magnetic particles in blood, i.e. the flow behavior of those mixtures present in medical applications in detail. It is foreseen to investigate the rheological behavior over a wide range of field strength, shear rate and fluid composition in rheological experiments using capillary rheology. The final goal of these investigations will be the establishment of a constitutive material law for the flow behavior of such suspensions in a magnetic field, which will allow simulations of biomedical applications.

在过去的几十年里，磁性颗粒悬浮液在生物医学应用中的应用-特别是在癌症治疗中的应用引起了越来越多的兴趣。在这种情况下，基本研究已经表明，特别是通常称为磁性药物靶向的方法的流体力学方面，即朝向肿瘤区域的磁控递送，仍然需要澄清许多基本方面。在这方面特别感兴趣的是在磁场的存在下，澄清基本的流体力学问题所需的各个悬浮液的粘性行为的变化。初步实验表明，生物相容性铁磁流体显示出显着增加，其粘度伴随着其流动行为的变化，即使在弱磁场的外观。这是由于在这种生物相容性铁磁流体中存在大量的磁性颗粒簇，表现出强磁矩，这引起了强的颗粒间相互作用。此外，初步调查还表明，即使用水或血液稀释液体，观察到的影响仍然存在。因此，该项目的中心目标是澄清血液中磁性颗粒悬浮液的流变学，即详细描述医疗应用中存在的这些混合物的流动行为。可以预见的是，在流变实验中，使用毛细管流变学研究在很宽的场强，剪切速率和流体组成范围内的流变行为。这些调查的最终目标将是建立一个本构材料法的流动行为，这种悬浮液在磁场中，这将允许模拟生物医学应用。