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CAREER: Reliable and Secure Minimally Invasive Bioelectronic Implants through Contextual Awareness

职业：通过情境意识实现可靠、安全的微创生物电子植入

基本信息

批准号：
2146476
负责人：
Kaiyuan Yang
金额：
$ 50万
依托单位：
William Marsh Rice University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2146476&HistoricalAwards=false
关键词：
CAREER Reliable Secure Minimally Invasive

项目摘要

Wireless, Battery-less, Minimally Invasive (WBMI) bioelectronics promise a plethora of transformative clinical and scientific applications benefiting human health and well-being. This CAREER project aims at studying and addressing the critical but largely overlooked reliability and security challenges in WBMI bioelectronic devices. Given the extreme power and size constraints of these devices, reliability and security protections cannot be an afterthought and must be designed holistically with the essential bioelectronic functionalities. This project will investigate and create theoretical foundations along with practical hardware and system implementations to tackle three critical challenges towards reliable and secure WBMI bioelectronic implants. The challenges include safe, efficient, and reliable wireless power transfer, secure access and communication in both remote telemedicine and emergency scenarios, and real-time monitoring of potential failures or attacks over extended periods of operation. The research outcome of this project will be a one-of-a-kind hardware platform that expedites the research and development of practically reliable and secure implantable bioelectronic systems for pre-clinical and clinical applications. Meanwhile, this project targets reinforcing the semiconductor hardware workforce by engaging and educating graduate, college, and high school students, especially the underrepresented minorities. This highly interdisciplinary project spanning materials, integrated circuits, power electronics, security, wireless communication, and computing, targets promoting interests in semiconductor and hardware, by engaging students at all levels in high-quality scientific and engineering research activities and creating educational materials to reach a much broader group of K-12 students and the public. This project will investigate principled and proactive methods to enable reliable and secure Wireless, Battery-less, Minimally Invasive (WBMI) bioelectronic implants. The key idea is to exploit positional and contextual awareness of the device to build reliability and security assurances within the fundamental power, communication, and control mechanisms. The research tasks include (1) safe, efficient, and misalignment-tolerant wireless power transfer to WBMI implants, (2) WBMI-specific secure authentication scheme for remote telemedicine and its lightweight implementation, and secure access and communication channel in emergency scenarios, and (3) novel specification-based online monitoring for the bioelectronic implants and transmitters and its efficient, compact hardware implementations. This project involves designing, optimizing, and prototyping energy-efficient miniature circuits and systems that blur traditional design boundaries to realize proactive protections with low overheads. Proof-of-principle implants integrating all the reliability and security protections studied in this project will be fabricated and experimentally evaluated.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

无线、无电池、微创 (WBMI) 生物电子学有望带来大量有益于人类健康和福祉的变革性临床和科学应用。该职业项目旨在研究和解决 WBMI 生物电子设备中关键但在很大程度上被忽视的可靠性和安全性挑战。考虑到这些设备的极端功率和尺寸限制，可靠性和安全保护不能是事后才想到的，必须与基本的生物电子功能进行整体设计。该项目将研究并创建理论基础以及实际的硬件和系统实施，以应对可靠和安全的 WBMI 生物电子植入物的三个关键挑战。这些挑战包括安全、高效、可靠的无线电力传输，远程医疗和紧急情况下的安全访问和通信，以及对长时间运行期间潜在故障或攻击的实时监控。该项目的研究成果将是一个独一无二的硬件平台，可加快临床前和临床应用的实际可靠且安全的可植入生物电子系统的研发。与此同时，该项目的目标是通过吸引和教育研究生、大学生和高中生，特别是代表性不足的少数族裔，来加强半导体硬件劳动力。这个高度跨学科的项目涵盖材料、集成电路、电力电子、安全、无线通信和计算，旨在通过让各个级别的学生参与高质量的科学和工程研究活动并创建教育材料来接触更广泛的 K-12 学生和公众群体，从而提高对半导体和硬件的兴趣。该项目将研究有原则的、主动的方法，以实现可靠、安全的无线、无电池、微创（WBMI）生物电子植入物。关键思想是利用设备的位置和上下文感知，在基本电源、通信和控制机制内建立可靠性和安全保证。研究任务包括（1）向WBMI植入物提供安全、高效且容错的无线功率传输，（2）用于远程远程医疗的WBMI特定安全认证方案及其轻量级实施，以及紧急情况下的安全访问和通信通道，以及（3）针对生物电子植入物和发射器的新颖的基于规范的在线监测及其高效、紧凑的硬件实施。该项目涉及节能微型电路和系统的设计、优化和原型设计，这些电路和系统模糊了传统设计界限，以低开销实现主动保护。将制造并实验评估集成了该项目中研究的所有可靠性和安全保护的原理验证植入物。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。