REU Site: IUPUI REU Program in Mathematics with Applications to Medicine, Neuroscience, and Fluid Dynamics

该奖项的全部或部分资金来自《2021年美国救援计划法案》(公法117-2)。印第安纳大学-普渡大学印第安纳波利斯分校(IUPUI)的REU项目将为来自美国各地的8名本科生提供机会，进行应用于医学、流体动力学和神经科学的数学研究。这些学生将在暑假期间在印第安纳波利斯与IUPUI数学科学系的教师导师一起工作八周。这个REU网站项目将向学生介绍跨学科的研究经验，并产生影响多个科学学科的新研究成果。具体地说，参与者将致力于四个主要项目之一：为心脏移植患者建立治疗策略模型；调查成瘾药物对大脑的影响；模拟邻近骨细胞上的力和液体流动以了解骨骼发育；以及研究健康和疾病中大脑节律的同步性。学生将提高在STEM相关领域继续其职业生涯所需的分析、逻辑和数值技能。该网站将培养一支多样化的、准备充分的STEM劳动力队伍。REU项目旨在解决移植免疫学、流体动力学和神经科学中新的和公开的问题。参与第一个REU项目的学生将与数学家和免疫学家密切合作，在存在新的组合治疗方法的情况下设计、分析和验证小鼠心脏移植的数学模型。第二个项目将涉及骨细胞及其周围间质液体和骨基质的多尺度综合模型。这个项目将使人们更好地了解骨骼的发育。在第三个项目中，学生们将开发一个数学模型(基于体内电生理实验数据)，该模型可以用来识别酒精受试者典型的异常决策背后的神经机制。第四个项目将需要数学建模，以了解神经同步在大脑功能中的作用。它将专注于了解睡眠期间大脑和心脏之间增加的交互作用。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). The REU Program at Indiana University-Purdue University Indianapolis (IUPUI) will provide eight undergraduate students from across the United States with the opportunity to conduct mathematics research applied to medicine, fluid dynamics, and neuroscience. The students will spend eight weeks during the summer in Indianapolis working with faculty mentors from the IUPUI Department of Mathematical Sciences. This REU Site program will introduce students to interdisciplinary research experience and yield new research outcomes that will impact multiple scientific disciplines. Specifically, the participants will work on one of four main projects: modeling treatment strategies for heart transplant patients, investigating the influence of addictive drugs on the brain, modeling the forces and fluid flow over neighboring bone cells to understand bone development, and studying synchronization of brain rhythms in health and disease. The students will advance the analytical, logical, and numerical skills that are needed to continue their careers in STEM-related fields. The Site will prepare a diverse and well-prepared STEM workforce. The REU projects aim to address new and open problems in transplant immunology, fluid dynamics, and neuroscience. Students participating in the first REU project will work closely with a mathematician and immunologist to design, analyze, and validate a mathematical model of mouse heart transplantation in the presence of novel combination therapeutic approaches. The second project will involve a multiscale integrative model of bone cells and their surrounding interstitial fluid and bone matrix. This project will lead to a better understanding of bone development. In the third project, the students will develop a mathematical model (based on in vivo electrophysiological experimental data) that can be used to identify the neural mechanisms that underlie aberrant decision-making typical for alcoholic subjects. The fourth project will require mathematical modeling to understand the role of neural synchronization in brain functions. It will focus on understanding the increased interactions between the brain and heart during sleep.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.