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Emotion regulation in patients with obsessive-compulsive disorder

强迫症患者的情绪调节

基本信息

批准号：
250782384
负责人：
Professorin Dr. Tanja Endrass
金额：
--
依托单位：
Institut für Psychologie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/250782384?language=en
关键词：
Emotion regulation patients obsessive compulsive

项目摘要

Emotional experience is based upon the interplay between the instantaneous appraisal of salient stimuli, provided by limbic brain areas, on the one hand, and prefrontal control mechanisms to adequately regulate the initial emotional response, on the other hand. In psychiatric disorders that are characterized by emotional hyperarousal, an imbalance of these two processes has been assumed (Phillips et al., 2003b). Models of emotional (dys)regulation may contribute to a better understanding of pathological anxiety experienced by patients with obsessive compulsive disorder (OCD). Initial evidence suggests that OCD is characterized by emotion regulation difficulties as indicated by self-report measures (de la Cruz et al., 2013). Further, OCD appears to be linked to functional changes in brain areas implicated in emotion processing and emotion regulation (Milad & Rauch, 2012). Thus, neuroimaging findings have demonstrated increased activity in both limbic and frontal brain areas during symptom provocation in OCD (e.g., Simon et al., 2010), suggesting altered cortico-limbic interactions, when OCD-relevant stimuli are being processed. However, emotion regulation strategies have not yet been directly examined in OCD. Therefore, we investigated in a first study, whether arousal elicited by anxiety-provoking stimuli can be reduced by visual distraction in OCD. Compared to a self-referential task, an attenuated amygdala response to OCD-relevant stimuli was found for patients during a visual distraction task (Simon et al., submitted). Because OCD-related anxiety is strongly influenced by dysfunctional beliefs and cognitive errors (e.g., catastrophizing), we suppose that emotion regulation is impaired in OCD patients specifically when using cognitive emotion regulation strategies. Therefore, this project aims at investigating cognitive emotion regulation (cognitive distraction and cognitive reappraisal) in OCD by using event-related potentials (study I) and examining whether emotion regulation deficits can be compensated when emotion regulation is guided externally (study II).

情绪体验的基础是对边缘脑区提供的显著刺激的即时评价与前额叶控制机制之间的相互作用，前额叶控制机制充分调节了最初的情绪反应。在以情绪过度觉醒为特征的精神障碍中，已经假定这两个过程的不平衡（菲利普斯等人，2003年b）。情绪（dys）调节模型可能有助于更好地理解强迫症（OCD）患者所经历的病理性焦虑。最初的证据表明，强迫症的特征在于自我报告测量所指示的情绪调节困难（de拉克鲁斯等人，2013年）。此外，强迫症似乎与涉及情绪处理和情绪调节的大脑区域的功能变化有关（Milad & Rauch，2012）。因此，神经影像学研究结果表明，在强迫症的症状激发期间，边缘系统和额叶脑区的活动增加（例如，Simon等人，2010），表明改变皮质边缘系统的相互作用，当强迫症相关的刺激正在处理。然而，情绪调节策略尚未直接在强迫症中进行研究。因此，我们在第一项研究中调查，是否唤醒引起焦虑的刺激可以减少视觉分心强迫症。与自我参照任务相比，在视觉分心任务期间发现患者对OCD相关刺激的杏仁核反应减弱（Simon等人，提交）。因为与OCD相关的焦虑受到功能失调的信念和认知错误的强烈影响（例如，灾难化），我们假设情绪调节受损的强迫症患者，特别是当使用认知情绪调节策略。因此，本研究旨在通过事件相关电位（研究I）和外部情绪调节（研究II）来研究强迫症患者的认知情绪调节（认知分心和认知重评）。