Common and Distinct Mechanisms of Social Anxiety and Alcohol Use

社交焦虑和饮酒的常见和独特机制

• 批准号: 438967918
• 负责人: Professorin Dr. Tanja Endrass
• 金额: --
• 依托单位: Institut für Klinische Psychologie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/438967918?language=en
• 关键词: Common; Distinct; Mechanisms; Social; Anxiety

Social anxiety disorder (SAD) co-occurs frequently with alcohol use disorder (AUD). Our project aims to disentangle common and specific behavioral and neuronal mechanisms of SAD and AUD to investigate potential shared vulnerabilities. Whereas SAD is associated with increased threat reactivity and performance monitoring, the risk to develop AUD is suggested to be enhanced under either altered threat reactivity or reward sensitivity and impulsivity. However, it remains unclear which combination of alterations in these mechanisms are associated with the comorbidity of SAD and AUD. Prior work suggests that there is an impulsive-anxious subtype among individuals with SAD which might account for problematic alcohol use and is associated with self-reported reward sensitivity and impulsivity. However, no study to date has investigated underlying mechanisms regarding this comorbidity. We will focus on markers robustly associated with anxiety or addiction. Threat reactivity will be assessed as startle response using electromyography in a no/predictable/unpredictable threat task. Markers for reward sensitivity will be striatal activity and reaction times in a monetary incentive delay task during functional magnetic resonance imaging. The error-related negativity will serve as a marker for performance monitoring and will be assessed in a flanker task using electroencephalography (EEG). Impulsivity will be examined with response inhibition and delay discounting. The N2 and P3 amplitude will serve as neuronal markers of response inhibition in a stop signal task during EEG. The discounting factor (k-value) will serve as a behavioral marker assessed in a delay discounting task. This multimethod study will be conducted in four groups of participants: Individuals with SAD, AUD, comorbid SAD + AUD and healthy controls. Besides dimensional and group comparison analyses for each mechanisms, we will conduct an overall latent class analysis to examine whether underlying behavioral and neuronal mechanisms explain across and beyond diagnoses the comorbidity of SAD and AUD. The results of this project would be highly relevant for understanding the comorbidity between the examined disorders and providing a basis for developing and improving tailored treatment procedures for individuals with SAD and AUD.

社交焦虑症（SAD）经常与酒精使用障碍（AUD）共同出现。我们的项目旨在消除SAD和AUD的共同行为和神经元机制，以研究潜在的共同脆弱性。尽管SAD与威胁反应性和性能监控的增加有关，但建议在改变威胁反应性或奖励敏感性和冲动性的情况下增强AUD的风险。但是，尚不清楚这些机制中哪种变化的组合与SAD和AUD的合并症有关。先前的工作表明，有SAD的个体中有一种冲动的不焦虑的亚型，这可能会导致有问题的饮酒，并且与自我报告的奖励敏感性和冲动性有关。但是，迄今为止尚未研究有关这种合并症的基本机制。我们将专注于与焦虑或成瘾牢固相关的标记。威胁反应性将在不可预测/无法预测的威胁任务中使用肌电图评估为惊吓反应。奖励灵敏度的标记将是功能磁共振成像期间的货币激励延迟任务中的纹状体活性和反应时间。与错误相关的负性将作为性能监测的标记，并将在侧面任务中评估脑电图（EEG）。冲动性将通过响应抑制和延迟打折检查。在脑电图期间，N2和P3振幅将作为停止信号任务中反应抑制的神经元标记。折现因子（K值）将作为在延迟折现任务中评估的行为标记。这项多方法研究将在四组参与者中进行：SAD，AUD，合并性SAD + AUD和健康对照的个人。除了对每种机制的维度和群体比较分析外，我们还将进行整体潜在类别分析，以检查潜在的行为和神经元机制是否在跨越诊断SAD和AUD的合并症之间解释了是否可以解释。该项目的结果与了解所检查的疾病之间的合并症以及为SAD和AUD的人开发和改善量身定制的治疗程序的基础高度相关。