Poly(phosphoester)s via Olefin Metathesis

本文介绍了通过烯烃复分解反应合成几种聚磷酸酯的方法。本提案的目的是实现对分子结构和微观结构的控制，以控制这种极有前途的聚合物类在生物应用方面的降解动力学。线性聚磷酸盐和-磷酸盐将通过无环二烯复分解（ADMET）聚合合成。特别是聚膦酸盐的合成引起了人们的高度关注，因为与聚磷酸盐相比，聚膦酸盐的水解动力学发生了变化，而ADMET首次以系统的方式研究了这类聚合物。此外，结构将通过在聚合物主链中引入分支而改变。将研究ADMET分支聚合的不同途径（AB2、A2+B3或B3途径），以设计具有不同分支程度的ppe。这些新型材料将被应用于可降解纳米颗粒的合成和体外实验。

This proposal describes the synthesis of several polyphosphoesters (PPEs) via olefin metathesis reactions. The aim of this proposal is to achieve control over molecular architecture and microstructure to control the degradation kinetics of this highly promising polymer class with respect to bioapplications. Linear poly(phosphate)s and -phosphonates will be synthesized via acyclic diene metathesis (ADMET) polymerization. Especially the synthesis of the poly(phosphonate)s is of high interest due to the altered hydrolysis kinetics compared to poly(phosphate)s and ADMET allows access to this class of polymers for the first time in a systematic manner. Further, the architecture will be altered by introducing branches in the polymer backbone. Different pathways for a branching ADMET polymerization (AB2, A2+B3 or B3 approaches) will be investigated to design PPEs with a variable degree of branching. All these novel materials will be applied for the synthesis of degradable nanoparticles that can be loaded with drugs etc. and tested in vitro.