Poly(phosphoester)s via Olefin Metathesis

该提案描述了通过烯烃复分解反应合成几种聚磷酸酯（PPE）。该提案的目的是实现对分子结构和微观结构的控制，以控制这种非常有前途的聚合物类在生物应用方面的降解动力学。通过无环二烯复分解（ADMET）聚合合成线性聚（磷酸酯）和-膦酸酯.特别是聚（膦酸酯）的合成由于与聚（磷酸酯）相比改变的水解动力学而引起高度关注，并且ADMET允许首次以系统的方式获得这类聚合物。此外，结构将通过在聚合物主链中引入支链而改变。将研究支化ADMET聚合的不同途径（AB 2、A2+B3或B3途径）以设计具有可变支化度的PPE。所有这些新材料将用于合成可降解的纳米颗粒，可以负载药物等，并在体外进行测试。

This proposal describes the synthesis of several polyphosphoesters (PPEs) via olefin metathesis reactions. The aim of this proposal is to achieve control over molecular architecture and microstructure to control the degradation kinetics of this highly promising polymer class with respect to bioapplications. Linear poly(phosphate)s and -phosphonates will be synthesized via acyclic diene metathesis (ADMET) polymerization. Especially the synthesis of the poly(phosphonate)s is of high interest due to the altered hydrolysis kinetics compared to poly(phosphate)s and ADMET allows access to this class of polymers for the first time in a systematic manner. Further, the architecture will be altered by introducing branches in the polymer backbone. Different pathways for a branching ADMET polymerization (AB2, A2+B3 or B3 approaches) will be investigated to design PPEs with a variable degree of branching. All these novel materials will be applied for the synthesis of degradable nanoparticles that can be loaded with drugs etc. and tested in vitro.