Sequence-controlled, multifunctional materials by living anionic polymerization of aziridines

氮丙啶活性阴离子聚合的顺序控制多功能材料

• 批准号: 271284690
• 负责人: Professor Dr. Frederik Wurm
• 金额: --
• 依托单位: Sustainable Polymer Chemistry Group
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/271284690?language=en
• 关键词: Sequence; controlled; multifunctional; materials; living

The proposal presents the sequence-controlled anionic polymerization of aziridines. To enable anionic ring-opening polymerization, the aziridine has to be activated by sulfonamides. For the first time different sulfonamides will be investigated with respect to their polymerization behavior and the first functional aziridine monomers for anionic polymerization are presented. The sulfonamide serves two functions: first to remove the acidic proton, i.e. as a protection group, and second to activate the ring by electron withdrawal. The activation has a direct influence on the reactivity of the active chain end (an azaanion), which will allow the first sequence-controlled anionic polymerization depending on the type of the activation group. Different functional groups will be attached to the aziridine (at the ring) and the polymerization behavior will be investigated. The resulting polysulfonamides will be hydrolyzed to release the respective polyamines. These materials will be investigated with respect to their DNA transfection activity. The establishment of a polymer (sequence) structure- DNA transfection activity relation will be conducted and compared to conventional non-viral gene transfection.

该建议提出了顺序控制的氮丙啶阴离子聚合。为了能够进行阴离子开环聚合，氮丙啶必须被磺酰胺活化。首次研究了不同磺酰胺类化合物的聚合行为，并提出了用于阴离子聚合的第一官能氮丙啶单体。磺酰胺有两个功能：首先是去除酸性质子，即作为保护基团，其次是通过吸电子激活环。活化对活性链端（氮杂阴离子）的反应性具有直接影响，这将允许取决于活化基团的类型的第一顺序控制的阴离子聚合。将不同的官能团连接到氮丙啶（在环上），并研究聚合行为。所得聚磺酰胺将水解以释放相应的聚胺。将研究这些材料的DNA转染活性。将进行聚合物（序列）结构- DNA转染活性关系的建立，并与常规非病毒基因转染进行比较。

项目成果

Microwave-Assisted Desulfonylation of Polysulfonamides toward Polypropylenimine.

• DOI: 10.1021/acsmacrolett.8b00180
• 发表时间: 2018-05
• 期刊: ACS macro letters
• 影响因子: 5.8
• 作者: E. Rieger;Tassilo Gleede;A. Manhart;M. Lamla;F. Wurm

Multihydroxy Polyamines by Living Anionic Polymerization of Aziridines.

• DOI: 10.1021/acsmacrolett.5b00901
• 发表时间: 2016-01
• 期刊: ACS macro letters
• 影响因子: 5.8
• 作者: E. Rieger;A. Manhart;F. Wurm

Alcohol- and Water-Tolerant Living Anionic Polymerization of Aziridines

• DOI: 10.1021/acs.macromol.8b01320
• 发表时间: 2018-08-14
• 期刊: MACROMOLECULES
• 影响因子: 5.5
• 作者: Gleede, Tassilo;Rieger, Elisabeth;Wurm, Frederik R.
• 通讯作者: Wurm, Frederik R.

The living anionic polymerization of activated aziridines: a systematic study of reaction conditions and kinetics

• DOI: 10.1039/c7py00436b
• 发表时间: 2017-05
• 期刊: Polymer Chemistry
• 影响因子: 4.6
• 作者: E. Rieger;Tassilo Gleede;Katja Weber;A. Manhart;M. Wagner;F. Wurm

Linear Well-Defined Polyamines via Anionic Ring-Opening Polymerization of Activated Aziridines: From Mild Desulfonylation to Cell Transfection.

• DOI: 10.1021/acsmacrolett.9b00792
• 发表时间: 2019-12
• 期刊: ACS macro letters
• 影响因子: 5.8
• 作者: Tassilo Gleede;Fangzhou Yu;Yingli Luo;Youyong Yuan;Jun Wang;F. Wurm