Conference: 2022 International Conference on ESCRT Biology

会议旨在为国际和国内研究一组调节细胞生物学许多基本功能的蛋白质（ESCRT蛋白质）的研究团体提供一个独特的开放，包容和互动的论坛。会议将为所有参与者，特别是本科生、研究生和博士后提供一个有效的学习环境。参与者还将有很好的机会与来自不同学科和生物学领域的研究人员交流，他们都对ESCRT的结构和功能有共同的兴趣。NSF基金将用于增加年轻研究人员参与的广度。会议将包括口头报告、海报会议和非正式讨论时间。本次会议的具体目标是：1)提供一个开放和包容的论坛，供其职业生涯各个层次的研究人员口头报告。将有充足的时间进行讨论。2)为所有参与者提供机会，特别是那些来自科学界代表性不足群体的参与者，在晚上的海报会议上展示和讨论他们的成果。3)通过共餐和社交活动，提供丰富的社交和社交机会。运输所需的内体复合物（ESCRT）机制包括不同的因子（人类约30种蛋白质，植物45种），这些因子在整个细胞中进行膜重塑和裂变反应。在过去的十年中，已知escrt介导的过程数量激增，包括内体蛋白运输、细胞动力学脱落、有丝分裂后核膜闭合、被包膜病毒出芽、外泌体生物发生、神经元修剪和膜修复。此外，最近在古细菌和细菌中发现了类似escrt的系统，使其成为自然界中最高度保守的机器之一。因此，ESCRT生物社区继续增长。尽管取得了这些进展，但仍有许多基本问题没有得到解答，包括ESCRT机制究竟是如何收缩和介导膜裂变的，以及许多ESCRT介导过程的生物学机制和后果。因此，现在时机已经成熟，可以把我们社区的不同部门聚集在一起，确保生物物理学家与细胞生物学家交流，生物化学家向植物生物学家学习，等等。为此，我们提议召开一次多学科会议，将涵盖ESCRT生物学的所有关键方面，并将包括以下主题的会议：1)ESCRT介导的膜裂变的生物物理学，2)丝介导的膜重塑的进化，3)ESCRT在细胞分裂中的作用，4)ESCRT在膜修复中的作用，5)ESCRT在疾病中的作用，以及6)ESCRT在其他系统（植物，古细菌）中的作用机制。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The meeting aims to provide a unique open, inclusive, and interactive forum for the international and domestic research community working on a group of proteins (ESCRT proteins) that regulate many basic functions of cell biology. The conference will provide an effective learning environment for all participants, especially undergraduate and graduate students, and postdoctoral fellows. Participants will also have great opportunities to mix with researchers from very different disciplines and fields of biology who are all drawn together by a common interest in ESCRT structures and functions. NSF funds will be used to increase the breadth of participation of young researchers. The meeting will include oral presentations, poster sessions, and time for informal discussions. The specific objectives of this conference are: 1) To provide an open and inclusive forum for oral presentations from researchers at all levels of their careers. Ample time will be devoted for discussion. 2) To provide an opportunity for all participants, specially to those from under-represented groups in science, to present and discuss their results in evening poster sessions. 3) To offer ample opportunities for networking and social interactions through shared meals and social activities.The Endosomal Complexes Required for Transport (ESCRT) machinery comprises different factors (~30 proteins in humans; 45 in plants) that carry out membrane remodeling and fission reactions throughout the cell. The past decade has seen an explosion in the number of processes now known to be ESCRT-mediated, including endosomal protein trafficking, cytokinetic abscission, closure of the post-mitotic nuclear envelope, enveloped virus budding, exosome biogenesis, neuronal pruning, and membrane repair. Furthermore, ESCRT-like systems have recently been discovered in archaea and bacteria, making this one of the most highly conserved machines in nature. As a result, the ESCRT biology community continues to grow. Despite these advances, a number of fundamental questions remain unanswered, including exactly how the ESCRT machinery constricts and mediates membrane fission, and the biological mechanisms and consequences of many ESCRT-mediated processes. The time is therefore again ripe to bring together the different segments of our community to ensure that biophysicists are talking to cell biologists, biochemists are learning from plant biologists, and so forth. Toward this end, we propose a multidisciplinary conference that will cover all key aspects of ESCRT biology and will include sessions on the following topics: 1) The biophysics of ESCRT-mediated membrane fission, 2) The evolution of filament-mediated membrane remodeling, 3) ESCRTs in cell division, 4) ESCRTs in membrane repair, 5) ESCRTs in disease, and 6) ESCRT machinery in other systems (plants, archaea).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.