MRI: Acquisition of a High-Speed Biplanar Fluoroscopy System for Non-Invasive Quantitative Imaging of Human Movement

MRI：获取高速双平面透视系统，用于人体运动的非侵入性定量成像

• 批准号: 2216029
• 负责人: Jason Franz
• 金额: $ 77.26万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2024-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216029&HistoricalAwards=false
• 关键词: MRI; Acquisition; Speed; Biplanar; Fluoroscopy

Movement is a critical to the human condition. The most common instrumentation used for measuring functional human movement relies on tracking the position of skin-mounted markers. Unfortunately, those systems have insurmountable limitations in accuracy which in turn limit research and teaching efforts from advancing our understanding of human movement. We seek to acquire a high-speed three-dimensional x-ray system to revolutionize the quantitative imaging of functional human movement across engineering, exercise science, biology, orthopedics, rehabilitation, and robotics. This acquisition will fill a critical gap in our capability to advance scientific discovery at UNC Chapel Hill (UNC-CH) while catalyzing collaboration with five regional institutions, including the largest historically black college (HBCU) in the country. The acquisition will also enhance coursework and experiential learning for ~3000 undergraduates and ~300 graduate students spanning 6 colleges and departments. We will further serve the national interest through outreach and engagement activities, collaborations with UNC-CH diversity and equity programs and our local HBCU, and creation of a unique summer Research Experience for Undergraduates proposal for the training of undergraduates historically disadvantaged in STEM fields.We propose to acquire a high-speed biplanar fluoroscopy (HS-BF) system for the non-invasive quantitative imaging of functional human movement across a wide range of scientific disciplines. HS-BF systems provide cine x-ray images at up to 1000 samples/s and directly quantify three-dimensional bone positions, orientations, and articulating surface mechanics that are impossible to capture with even the most sophisticated of comparable technologies. Our HS-BF system will be made broadly available to an enthusiastic network of faculty and students at UNC-CH and our five partnering institutions through an established Collaborative Fluoroscopy Research Core. This acquisition will address critical limitations in our region’s ability to objectively quantify the fundamental mechanics of human movement with opportunities for significant impact. Specifically, our network of researchers and collaborators, as well as the diverse student bodies we serve, will have the capability to measure with unparalleled resolution the precise complexities of bone motion critical to overcoming the contemporary challenges across our research disciplines and for the benefit of society, including: (1) understanding how musculoskeletal mechanics and function are achieved and maintained over the mammalian lifespan, (2) developing mechanistic links between movement biomechanics and underlying biology, (3) identifying opportunities for surgical innovation, (4) advancing ergonomics and occupational science for a strong and vibrant workforce, (5) developing more sophisticated bioengineered materials/tissues, and (6) advancing next generation rehabilitation robotics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

运动是人类生存的关键。用于测量功能性人体运动的最常见仪器依赖于跟踪皮肤安装标记的位置。不幸的是，这些系统在准确性方面有着无法克服的局限性，这反过来又限制了我们对人类运动的理解的研究和教学工作。我们寻求获得一个高速三维X射线系统，以彻底改变工程，运动科学，生物学，骨科，康复和机器人技术中功能性人体运动的定量成像。此次收购将填补我们在查佩尔山（UNC-CH）推进科学发现能力的关键空白，同时促进与五个区域机构的合作，包括该国历史上最大的黑人学院（HBCU）。此次收购还将为6个学院和系的约3000名本科生和约300名研究生加强课程和体验式学习。我们将通过外联和参与活动，与UNC-CH多样性和公平方案以及我们当地的HBCU合作，进一步为国家利益服务，和创建一个独特的夏季研究经验的本科生的建议，为本科生的培训历史上处于不利地位的STEM领域。我们建议获得一个高速双平面透视（HS-BF）系统的非-在广泛的科学学科中对功能性人体运动进行侵入性定量成像。HS-BF系统可提供高达1000个样本/s的电影X射线图像，并直接量化三维骨位置、方向和关节面力学，即使是最复杂的可比技术也无法捕获这些信息。我们的HS-BF系统将广泛提供给UNC-CH和我们的五个合作机构的热情的教师和学生网络，通过一个既定的协作荧光透视研究核心。此次收购将解决我们地区客观量化人类运动基本机制的能力的关键限制，并有机会产生重大影响。具体来说，我们的研究人员和合作者网络，以及我们所服务的不同学生团体，将有能力以无与伦比的分辨率测量骨骼运动的精确复杂性，这对于克服我们研究学科的当代挑战和造福社会至关重要，包括：（1）了解肌肉骨骼力学和功能是如何在哺乳动物的一生中实现和维持的，（2）发展运动生物力学和基础生物学之间的机械联系，（3）发现外科创新的机会，（4）推进人体工程学和职业科学，以建立强大而充满活力的劳动力队伍，（5）开发更复杂的生物工程材料/组织，（6）推进下一代康复机器人技术。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。