ISS: The Effects of Age on the Mechanochemical Feedback Loop for Extracellular Matrix Production by Fibroblasts in the Context of Wound Healing

ISS:年龄对伤口愈合中成纤维细胞产生细胞外基质的机械化学反馈环的影响

基本信息

  • 批准号:
    2223497
  • 负责人:
  • 金额:
    $ 40万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-01 至 2025-12-31
  • 项目状态:
    未结题

项目摘要

The goal of this project is to understand the impact of ageing on the healing process. As people age, they heal less efficiently in response to inflammation and injury. There is evidence that changes within fibroblasts, the cells responsible for production of extracellular matrix, play a significant role in alterations to healing response. In this project, a team from Tufts University will assess the impact of cellular age and the age of the extracellular matrix on models of wound healing. The unique environment aboard the International Space Station (ISS) will be leveraged to simulate processes associated with ageing. The outcomes of this project will serve the national interest by training the next generation of scientists, encouraging students at the middle and high school levels to pursue careers in research, and by advancing health via a more fundamental understanding of wound healing with age.The project plans to explore how changes associated with ageing of the extracellular matrix and fibroblasts, and their interaction, influence tissue dysfunction and impaired healing with age and exposure to microgravity. While previous work has assessed the effects of microgravity on fibroblasts and wound healing, there has been no attempt to evaluate this impact in the context of developmental age, even though healing effectiveness varies significantly with age. Two specific research objectives are pursued. First, the investigators will determine the effects of microgravity on fibroblast phenotype as a function of tissue type and developmental age. Second, the impacts of simulated aging via microgravity exposure aboard the ISS on wound healing response in ontogenetic mimics of tissue stroma will be investigated. A novel silk-extracellular matrix hydrogel system will be deployed to decouple cellular and extracellular contributions to this process for the first time. These studies will elucidate the mechanisms of altered wound healing associated with microgravity and inform our understanding of how ageing impacts these same phenomena on Earth. This knowledge could lead to new treatments to promote better wound healing and restore tissue function throughout the body.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个项目的目标是了解衰老对愈合过程的影响。随着人们年龄的增长,他们对炎症和损伤的反应会变得不那么有效。有证据表明,成纤维细胞内的变化在愈合反应的变化中起着重要作用。成纤维细胞负责产生细胞外基质。在这个项目中,塔夫茨大学的一个团队将评估细胞年龄和细胞外基质的年龄对伤口愈合模型的影响。将利用国际空间站(ISS)上独特的环境来模拟与老龄化有关的过程。该项目的成果将服务于国家利益,通过培训下一代科学家,鼓励初中和高中水平的学生从事研究工作,并通过更基本地了解伤口随年龄的愈合来促进健康。该项目计划探索与细胞外基质和成纤维细胞老化相关的变化及其相互作用如何影响组织功能障碍和随着年龄和微重力暴露而受损的愈合。虽然之前的工作已经评估了微重力对成纤维细胞和伤口愈合的影响,但还没有人试图在发育年龄的背景下评估这种影响,尽管愈合效果随着年龄的变化而显著不同。追求两个具体的研究目标。首先,研究人员将确定微重力对成纤维细胞表型的影响,作为组织类型和发育年龄的函数。其次,将研究在国际空间站上通过微重力暴露模拟老化对个体发育模拟组织基质的伤口愈合反应的影响。一种新的丝素-细胞外基质水凝胶系统将首次用于解偶联细胞和细胞外对这一过程的贡献。这些研究将阐明与微重力相关的伤口愈合变化的机制,并让我们了解衰老如何影响地球上的这些相同现象。这一知识可能导致新的治疗方法,以促进更好的伤口愈合和恢复全身组织功能。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(0)
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Lauren Black其他文献

Utilization of a multidisciplinary emergency department sepsis huddle to reduce time to antibiotics and improve SEP-1 compliance.
利用多学科急诊科脓毒症小组来减少使用抗生素的时间并提高 SEP-1 依从性。
  • DOI:
    10.1016/j.ajem.2020.09.014
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Sonis;T. Benzer;Lauren Black;M. Filbin;B. Hayes;K. Hibbert;C. Kraus;A. Raja;E. Temin;Maria Vareschi;B. White;Susan R. Wilcox;E. Aaronson
  • 通讯作者:
    E. Aaronson
Keeping Patients at Risk for Self-Harm Safe in the Emergency Department: A Protocolized Approach.
确保急诊科患者处于自残风险的安全:协议化方法。

Lauren Black的其他文献

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{{ truncateString('Lauren Black', 18)}}的其他基金

Identification and Characterization of Matrikines for Cardiac Differentiation and Regeneration
用于心脏分化和再生的 Matrikines 的鉴定和表征
  • 批准号:
    1603524
  • 财政年份:
    2016
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
CAREER: Biophysical Control of Cardiac Differentiation in Patient Specific Cardiac Stem Cells
职业:患者特异性心脏干细胞心脏分化的生物物理控制
  • 批准号:
    1351241
  • 财政年份:
    2014
  • 资助金额:
    $ 40万
  • 项目类别:
    Continuing Grant

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