SBIR Phase II: Development of AI Software to Capture and Identify Circulating Rare Cells in Lung Patients
SBIR 第二阶段:开发人工智能软件来捕获和识别肺部患者的循环稀有细胞
基本信息
- 批准号:2230782
- 负责人:
- 金额:$ 99.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Cooperative Agreement
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is a new cancer treatment liquid biopsy product using Artificial Intelligence (AI) that can detect and classify cancer derived rare cell (CRC) from a blood draw. There are over 100 different types of cancers and over 1.9 million new cancer cases are expected to be diagnosed in the US in 2022 resulting in over 600,000 deaths (1,670 deaths per day). Cancer is the second most common cause of death in the US, exceeded only by heart disease. New treatment therapies are being developed for a substantial proportion of cancers with many clinical trials for new therapies on-going world-wide. The minimally invasive, high sensitivity blood test will monitor therapeutic response and progression at low-cost, supporting development of these new cancer treatments. Specifically, with a less invasive and more comprehensive diagnostic tool, the test results will give clinical researchers real-time insights into cancer tumor biology, providing better understanding of cancer heterogeneity. This Small Business Innovation Research (SBIR) Phase II project combines Artificial Intelligence (AI), specifically deep learning neural networks used for computer vision, with CRC immunofluorescent reagents integrated into an immunofluorescent microscope. The main objective of this effort is to identify and classify CRCs with high accuracy. There is increasing evidence that CRCs are correlated with cancer type, staging, treatment response, minimal residual disease, and overall disease progression. However, in a typical blood sample, there are over 7 million blood artifacts with very few CRCs present. Current techniques to analyze CRCs are expensive, lengthy, and are limited in automation. To meet project sensitivity, specificity, and runtime requirements, the AI image analysis will be further optimized to: 1) find CRCs, 2) discriminate against false positives, and 3) classify CRCs into clinically relevant types. The developed AI architectures will be selected through extensive training using thousands of clinical samples compared to expertly characterized cancer blood pathology images. After high sensitivity and specificity are demonstrated, development work will continue to mature the AI-revolutionized CRC liquid biopsy test to meet clinical research use only (RUO) requirements. For the cancer research community, the product offering will be used in the conduct of non-clinical laboratory research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个小型企业创新研究(SBIR)第二阶段项目的更广泛的影响/商业潜力是一种使用人工智能(AI)的新型癌症治疗液体活检产品,可以从血液中检测和分类癌症衍生的罕见细胞(CRC)。 有超过100种不同类型的癌症,预计2022年美国将诊断出超过190万例新的癌症病例,导致超过60万例死亡(每天1,670例死亡)。癌症是美国第二大常见的死亡原因,仅次于心脏病。正在开发针对大部分癌症的新治疗方法,世界各地正在进行许多新疗法的临床试验。这种微创、高灵敏度的血液检测将以低成本监测治疗反应和进展,支持这些新的癌症治疗方法的开发。 具体而言,通过更少侵入性和更全面的诊断工具,测试结果将为临床研究人员提供对癌症肿瘤生物学的实时见解,从而更好地了解癌症异质性。 这个小型企业创新研究(SBIR)第二阶段项目将人工智能(AI),特别是用于计算机视觉的深度学习神经网络与集成到免疫荧光显微镜中的CRC免疫荧光试剂相结合。 这项工作的主要目标是以高精度识别和分类CRC。越来越多的证据表明,CRC与癌症类型、分期、治疗反应、微小残留病变和总体疾病进展相关。然而,在典型的血液样本中,存在超过700万个血液伪影,其中存在非常少的CRC。 目前分析CRC的技术是昂贵的,冗长的,并且在自动化方面受到限制。 为了满足项目的灵敏度、特异性和运行时间要求,AI图像分析将进一步优化:1)发现CRC,2)区分假阳性,3)将CRC分类为临床相关类型。 开发的AI架构将通过使用数千个临床样本进行广泛的训练来选择,并与专业表征的癌症血液病理学图像进行比较。 在证明了高灵敏度和特异性之后,开发工作将继续使AI革命性的CRC液体活检测试成熟,以满足临床研究专用(RUO)要求。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Yongjian Yu其他文献
Exploring the ecological interactions of emBacillus/em and their contribution to characteristic aroma components in Zhenjiang aromatic vinegar
探索芽孢杆菌及其在镇江香醋特征香气成分中所起的生态相互作用
- DOI:
10.1016/j.fbio.2023.102900 - 发表时间:
2023-08-01 - 期刊:
- 影响因子:5.900
- 作者:
Jiaxin Liu;Yongjian Yu;Xiaoting Ye;Ke Wang;Yuanyuan Zhu;Yuqin Wang;Zhen Yu;Peng Liu - 通讯作者:
Peng Liu
Automatic Detection and Identification of Trichomonas Vaginalis from Fluorescence Microscopy Images
荧光显微镜图像自动检测和识别阴道毛滴虫
- DOI:
10.5220/0010993400003123 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Yongjian Yu;Jue Wang - 通讯作者:
Jue Wang
Optimization and characterization of a biphasic solvent system for vinegar residue pretreatment: Enhanced fractionation efficiency, propionic acid production, and sustainability
- DOI:
10.1016/j.indcrop.2024.119575 - 发表时间:
2024-12-15 - 期刊:
- 影响因子:
- 作者:
Ruijun Tang;Yuanyuan Zhu;Yongjian Yu;Siyuan Cheng;Liyi Zhou;Ke Wang - 通讯作者:
Ke Wang
Fluorescence Image Visualization using Multi-Channel Minimax Optimization (MCMO)
使用多通道极小极大优化 (MCMO) 进行荧光图像可视化
- DOI:
10.1109/cbms58004.2023.00205 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Yongjian Yu;Jue Wang - 通讯作者:
Jue Wang
Polarimetric SAR image segmentation using texture partitioning and statistical analysis
使用纹理分区和统计分析的偏振 SAR 图像分割
- DOI:
10.1109/icip.2000.901049 - 发表时间:
2000 - 期刊:
- 影响因子:0
- 作者:
Yongjian Yu;S. Acton - 通讯作者:
S. Acton
Yongjian Yu的其他文献
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{{ truncateString('Yongjian Yu', 18)}}的其他基金
SBIR Phase I: Development of AI Software to Capture and Identify Circulating Rare Cells in Lung Patients
SBIR 第一阶段:开发人工智能软件来捕获和识别肺部患者的循环稀有细胞
- 批准号:
2015008 - 财政年份:2020
- 资助金额:
$ 99.97万 - 项目类别:
Standard Grant
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